2018
DOI: 10.18632/aging.101573 View full text |Buy / Rent full text
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Abstract: Circular RNAs (circRNAs) have recently been confirmed to participate in different pathological processes, including cancer progression. However, the role and precise mechanism of action of the majority of circRNAs have not been elucidated in bladder cancer (BC). Here, we identified a novel circular RNA, termed circUBXN7, which was significantly downregulated in BC tissues compared with matched nontumor tissues. Importantly, we found that decreased circUBXN7 expression was associated with pathological stage, gr… Show more

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“…Emerging studies have revealed that dysregulated expression of key cir-cRNAs could disturb the balance of ceRNA network, leading to the tumorigenesis and development of cancer. For example, circular RNA circUBXN7 inhibits cell growth and invasion via sponging miR-1247-3p to increase B4GALT3 expression in bladder cancer [16]. Moreover, circTADA2As suppress development and metastasis of breast cancer by targeting miR-203a-3p/ SOCS3 axis [17].…”
Section: Introductionmentioning
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“…Emerging studies have revealed that dysregulated expression of key cir-cRNAs could disturb the balance of ceRNA network, leading to the tumorigenesis and development of cancer. For example, circular RNA circUBXN7 inhibits cell growth and invasion via sponging miR-1247-3p to increase B4GALT3 expression in bladder cancer [16]. Moreover, circTADA2As suppress development and metastasis of breast cancer by targeting miR-203a-3p/ SOCS3 axis [17].…”
Section: Introductionmentioning
“…Mechanistically, circ-UBXN7 can function as a competitive endogenous RNA (ceRNA) of miR-1247-3p that enhances B4GALT3 expression, consequently inhibiting BC cell viability and invasion. Consequently, the circ-UBXN7-miR-1247-3p-B4GALT3 regulatory network should be a potential target for treating BC (Liu et al, 2018a;Liu et al, 2018b). Liu et al (2018a) and Liu et al (2018b) reported that circ-FNDC3B also functions as a tumor suppressor in BC.…”
Section: Inhibitor Activitiesmentioning
“…Consequently, the circ-UBXN7-miR-1247-3p-B4GALT3 regulatory network should be a potential target for treating BC (Liu et al, 2018a;Liu et al, 2018b). Liu et al (2018a) and Liu et al (2018b) reported that circ-FNDC3B also functions as a tumor suppressor in BC. circ-FNDC3B is a highly stable and cytoplasmic circRNA derived from exons 5 and 6 of the FNDC3B gene locus that is expressed at low levels in BC cell lines and tissues, and associated with pathological T stage, grade, lymphatic invasion, and the overall survival rates of patients.…”
Section: Inhibitor Activitiesmentioning
“…Several circRNAs have been reported to regulate the progression of BC. For example, circUBXN7 were identified to suppress BC cancer viability and metastasis [11]. circSLC8A1 acts as a ceRNA of miR-130b/miR-494 to regulate PTEN expression and thus inhibits BC progression [12].…”
Section: Introductionmentioning