volume 10, issue 6, P1281-1293 2018
DOI: 10.18632/aging.101466
View full text
Qiuling Sang, Xiaoyang Liu, Libo Wang, Ling Qi, Wenping Sun, Weiyao Wang, Yajuan Sun, Haina Zhang

Abstract: We aimed to explore the mechanism of pramipexole (PPX) actions in the treatment of Parkinson’s disease (PD). Genes related to PD and PPX were screened through bioinformatics retrieval. The PD model was constructed by applying 1-methyl-4-phenylpyridinium (MMP+). The RNA expression levels of circSNCA, SNCA, apoptosis-related genes (BCL2, CASP3, BAX, PTEN and P53) and miR-7 were detected by qRT-PCR. Protein expression was determined by western blot. The interactions between circSNCA-miR-7-SNCA were verified by du…

expand abstract