2015
DOI: 10.1080/15476286.2015.1128065
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Abstract: Circular RNAs (circRNAs) are widely expressed in animal cells, but their biogenesis and functions are poorly understood. CircRNAs have been shown to act as sponges for miRNAs and may also potentially sponge RNA-binding proteins (RBPs) and are thus predicted to function as robust posttranscriptional regulators of gene expression. The joint analysis of large-scale transcriptome data coupled with computational analyses represents a powerful approach to elucidate possible biological roles of ribonucleoprotein (RNP… Show more

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Cited by 903 publications
(693 citation statements)
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“…These circRNAs were the most abundant and/or were also present in ≥2 individuals in our sequencing. Divergent primers for each circRNA were designed using CircInteractome (Dudekula et al., 2016). Each primer set was validated initially by examining RNA isolated from PBMCs, HUVECs, and serum.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…These circRNAs were the most abundant and/or were also present in ≥2 individuals in our sequencing. Divergent primers for each circRNA were designed using CircInteractome (Dudekula et al., 2016). Each primer set was validated initially by examining RNA isolated from PBMCs, HUVECs, and serum.…”
Section: Resultsmentioning
confidence: 99%
“…Divergent primers for circRNAs were designed using the CircInteractome web tool (https://circinteractome.nia.nih.gov/Divergent_Primers/divergent_primers.html) (Dudekula et al., 2016). cDNA used to validate linear transcripts (see above) was used for RT‐qPCR reactions.…”
Section: Methodsmentioning
confidence: 99%
“…21,22 Here, we identified HuR-associated circRNAs using RIP-chip and RIP-RT-qPCR analyses, bioinformatic prediction, and in vitro binding assays (Figs. 1-3, Table S2).…”
Section: Discussionmentioning
confidence: 99%
“…33 CircInteractome is a web-tool for exploring circular RNAs and their interacting proteins and miRNAs. 34 The design of divergent primers and specific siRNA for circRNA was also provided by circInteractome. CIRCpedia is an integrative database, aiming to annotating alternative back-splicing and alternative splicing in circRNAs across different cell lines.…”
Section: Introductionmentioning
confidence: 99%