Circadian organization of lipid landscape is perturbed in type 2 diabetic patients

Sinturel, Flore; Chera, Simona; Brulhart-Meynet, Marie-Claude; Montoya, Jonathan Paz; Stenvers, Dirk Jan; Bisschop, Peter H.; Kalsbeek, Andries; Guessous, Idris; Jornayvaz, François R.; Philippe, Jacques; Brown, Steven A.; D’Angelo, Giovanni; Riezman, Howard; Dibner, Charna

doi:10.1016/j.xcrm.2023.101299

Cited by 1 publication

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“…Circadian oscillators play pivotal roles in regulating nearly all the aspects of body physiology via temporal orchestration of gene transcription, post-transcriptional events, protein synthesis and post-translational modifications (reviewed in (Bass, 2017;Finger et al, 2020)). Furthermore, lipids and metabolites follow diurnal profiles in blood and tissues, highlighting the critical importance of circadian rhythmicity for metabolic landscape (Chua et al, 2013;Held et al, 2020;Petrenko et al, 2022;Petrenko et al, 2023;Sinturel et al, 2023). The organspecific fluctuations observed in the circadian landscape emphasize the fine-tuning required for each organ and even each cell type to perform its biological role (Gachon et al, 2017;Petrenko et al, 2018;Sinturel et al, 2020).…”

Section: In Memoriammentioning

confidence: 99%

Human primary cells can tell body time: Dedicated to Steven A. Brown

Katsioudi,

Biancolin,

Jiménez‐Sanchez

et al. 2024

Eur J of Neuroscience

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The field of chronobiology has advanced significantly since ancient observations of natural rhythms. The intricate molecular architecture of circadian clocks, their hierarchical organization within the mammalian body, and their pivotal roles in organ physiology highlight the complexity and significance of these internal timekeeping mechanisms. In humans, circadian phenotypes exhibit considerable variability among individuals and throughout the individual's lifespan. A fundamental challenge in mechanistic studies of human chronobiology arises from the difficulty of conducting serial sampling from most organs. The concept of studying circadian clocks in vitro relies on the groundbreaking discovery by Ueli Schibler and colleagues that nearly every cell in the body harbours autonomous molecular oscillators. The advent of circadian bioluminescent reporters has provided a new perspective for this approach, enabling high‐resolution continuous measurements of cell‐autonomous clocks in cultured cells, following in vitro synchronization pulse. The work by Steven A. Brown has provided compelling evidence that clock characteristics assessed in primary mouse and human skin fibroblasts cultured in vitro represent a reliable estimation of internal clock properties in vivo. The in vitro approach for studying molecular human clocks in cultured explants and primary cells, pioneered by Steve Brown, represents an invaluable tool for assessing inter‐individual differences in circadian characteristics alongside comprehensive genetic, biochemical and functional analyses. In a broader context, this reliable and minimally invasive approach offers a unique perspective for unravelling the functional inputs and outputs of oscillators operative in nearly any human tissue in physiological contexts and across various pathologies.

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