Circadian change of serum concentration of small dense LDL-cholesterol in type 2 diabetic patients

Hirayama, Satoshi; Soda, Satoshi; Ito, Yasuki; Matsui, Hiroshi; Ueno, Toshihide; Fukushima, Yoshifumi; Ohmura, Hirotoshi; Hanyu, Osamu; Aizawa, Yoshifusa; Miida, Takashi

doi:10.1016/j.cca.2009.11.017

Cited by 18 publications

(17 citation statements)

References 27 publications

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“…CETP, a protein that is known to interact with HDL and VLDL, has a relatively slow FSR of about 0.40 pools/day, slightly more rapid than that measured for HDL apoA-I (approximately 0.26 pools/day). The relatively slow FSR measured is consistent with the findings that CETP is largely associated with HDL in plasma (18 ) and that the concentrations remain relatively constant over the course of the day (19 ). In contrast, PCSK9 had a more rapid FSR of about 2-4 pools/day, which was slightly less than that for VLDL apoB100 (approximately 6.5 pools/day).…”

Section: Discussionsupporting

confidence: 85%

Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry

et al. 2012

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BACKGROUND: Current approaches to measure protein turnover that use stable isotope-labeled tracers via GC-MS are limited to a small number of relatively abundant proteins. We developed a multiplexed liquid chromatography-selected reaction monitoring mass spectrometry (LC-SRM) assay to measure protein turnover and compared the fractional synthetic rates (FSRs) for 2 proteins, VLDL apolipoprotein B100 (VLDL apoB100) and HDL apoA-I, measured by both methods. We applied this technique to other proteins for which kinetics are not readily measured with GC-MS.

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Section: Discussionsupporting

confidence: 85%

Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry

et al. 2012

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“…Common factors such as age, sex, hypertension, diabetes, elevated TC and LDL‐C levels, decreased HDL‐C level, smoking, and family history have prognostic value, especially LDL‐C elevation, which is considered the most important traditional risk factor for cerebral infarction. CAS is the pathological basis of ACI, and sdLDL‐C, one of the subcomponents of LDL‐C, is more potent than coronary atherosclerosis . The results of this study show that the level of sdLDL‐C in the ACI group was significantly higher than that in the control group ( P < 0.001); further studies found that the level of sdLDL‐C in the unstable plaque group was significantly higher than that in the stable plaque group and the plaque‐free group ( P < 0.05, P < 0.001).…”

Section: Discussionmentioning

confidence: 56%

Correlation between of small dense low‐density lipoprotein cholesterol with acute cerebral infarction and carotid atherosclerotic plaque stability

QiaoZhen

Meng

Wang

et al. 2019

Clinical Laboratory Analysis

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BackgroundAcute cerebral infarction (ACI) is seriously harmful to human health worldwide. However, at present, the risk of disease onset is still not accurately predicted for some people.MethodsFive hundred and nineteen patients with ACI and 300 healthy controls were included in this study. We divided the patients into three groups according to the results of cervical artery contrast‐enhanced ultrasound. Ninety‐five patients were in the CAS without plaque group, 108 patients were in the stable plaque group, and 316 patients were in the unstable plaque group. TC, TG, HDL‐C, LDL‐C, and sdLDL‐C were measured in all subjects.ResultsThe level of small dense low‐density lipoprotein cholesterol (sdLDL‐C) in the ACI group was significantly higher than that in the control group (P < 0.001). Logistic regression analysis showed that sdLDL‐C was an independent risk factor for ACI (OR = 1.067, 95% CI: 1.041‐1.093, P < 0.001); serum sdLDL‐C was significantly higher in the unstable plaque group than in the stable plaque group and plaque‐free group (P < 0.05, P < 0.001); serum sdLDL‐C was also higher in the stable plaque group than the plaque‐free group (P < 0.001). Logistic regression analysis showed that sdLDL‐C was an independent risk factor for unstable carotid plaques (OR = 1.053, 95% CI: 1.038‐1.068, P < 0.001); Spearman correlation analysis showed that sdLDL‐C test results were positively correlated with carotid plaque stability (r = 0.363, P < 0.001).ConclusionSmall dense low‐density lipoprotein cholesterol is an independent risk factor for the onset of ACI and may be an early serum marker for this disease.

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“…The reason for the negative findings is not completely clear, but may be due to the fact that all patients were taking statins, which generally lower sdLDL-C (25). There was also variability in the time of day when patients were sampled, which could also be a contributing factor; sdLDL-C has been shown to exhibit circadian change, with highest values in the morning followed by a steady decrease during the day (26). In the Framingham Offspring Study (27), women with CHD had higher sdLDL-C concentrations than controls, but men did not exhibit this difference.…”

Section: Discussionmentioning

confidence: 99%

Relationship of baseline HDL subclasses, small dense LDL and LDL triglyceride to cardiovascular events in the AIM-HIGH clinical trial

Albers

Slee²,

Fleg

et al. 2016

Atherosclerosis

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Background and aims-Previous results of the AIM-HIGH trial showed that baseline levels of the conventional lipid parameters were not predictive of future cardiovascular (CV) outcomes. The aims of this secondary analysis were to examine the levels of cholesterol in high density lipoprotein (HDL) subclasses (HDL2-C and HDL3-C), small dense low density lipoprotein (sdLDL-C), and LDL triglyceride (LDL-TG) at baseline, as well as the relationship between these levels and CV outcomes.

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Circadian change of serum concentration of small dense LDL-cholesterol in type 2 diabetic patients

Cited by 18 publications

References 27 publications

Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry

Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry

Correlation between of small dense low‐density lipoprotein cholesterol with acute cerebral infarction and carotid atherosclerotic plaque stability

Relationship of baseline HDL subclasses, small dense LDL and LDL triglyceride to cardiovascular events in the AIM-HIGH clinical trial

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