Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma
Yixin Wen,
Feng Xu,
Hui Zhang
Abstract:BACKGROUND: Circular RNAs (circRNAs) perform key regulatory functions in osteosarcoma (OS) tumorigenesis. In this study, we aimed to explore the detailed action mechanisms of circ_0049271 in OS progression. METHODS: Cell colony formation, cell counting kit-8, and transwell assays were performed to assess the proliferation and invasion of OS cells. Quantitative reverse transcription-polymerase chain reaction and western blotting were used to determine the expression levels of polymerase 1 and transcript release… Show more
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