Ciprofloxacin-Resistant
 Salmonella enterica
 Serovar Typhi from Kuwait with Novel Mutations in
 gyrA
 and
 parC
 Genes

Dimitrov, T; Dashti, Ali A.; Albaksami, Ossama; Udo, Edet E.; Jadaon, Mehrez M.; Albert, M. John

doi:10.1128/jcm.01161-08

Cited by 32 publications

(43 citation statements)

References 26 publications

(27 reference statements)

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“…in Cambodia, where S. typhi susceptibility to ciprofloxacin and ceftriaxone were 79% and 81% respectively. Similarly, a study on ciprofloxacin resistant S. typhi and treatment failure in the Kuwait by Dimitrov et al 18 also revealed susceptibility of 63.3% and 67.3% for ciprofloxacin and ceftriaxone respectively, which were considered to be high. The high susceptibility of S. typhi to ciprofloxacin and ceftriaxone recorded at the three hospitals may be due to the fact that ciprofloxacin and ceftriaxone have recently been introduced on the Ghanaian market and so might not have been subjected to abuse as compared to ampicillin 9 .…”

Section: Resultsmentioning

confidence: 99%

“…Some other factors identified in literature as the drivers of bacterial resistance to antibiotics such as unnecessary prescriptions and substandard antibiotics could also be the cause of the S. typhi resistance observed against the antibiotics in this study 17,18 . The usefulness of these antibiotics will therefore depend on the effective interventions put in place by health authorities to curb the spread of resistance among bacterial strains to antibiotics 7 .…”

Section: Figure 2: Antimicrobial Susceptibility Patterns Of S Typhi mentioning

confidence: 99%

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Untitled

2014

IJPSR

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Salmonella typhi, causative agent of typhoid fever, a predominantly human communicable disease, is endemic in Africa and Asia. S. typhi is of clinical importance partly due to its mode of infection and partly due to the fact that human activities such as poor hygienic conditions are essential in the transmission and perpetuation of the pathogen. More so antibiotic resistant strains of S. typhi have emerged, increasing cost of treatment, morbidity and mortality. Meanwhile, S. typhi isolation and sensitivity testing to antibiotics are rarely practiced in the hospitals in and around Kumasi. This study sought to determine the extent of antibiotic susceptibility of S. typhi isolated from patients in Kumasi south, North Suntreso and Tafo hospitals in the Ashanti region of Ghana. The isolates were identified using morphological and biochemical means. The isolates were then tested for their sensitivity to some reference antibiotics using the Kirby-Bauer disc diffusion method. One hundred and twenty-eight (128) S. typhi were isolated from 900 clinical samples. A total of 52.3% of the S. typhi isolates exhibited resistance to ampicillin whereas 32.8, 25.0, 17.2 and 14.9% of the isolates were resistant to co-trimoxazole, chloramphenicol, ciprofloxacin and ceftriaxone respectively. About 19.5% of the S. typhi isolates were multidrug resistant. The S. typhi isolates were most sensitive to ciprofloxacin and ceftriaxone whilst majority of the S. typhi tested were resistant to ampicillin. Ampicillin is therefore no longer suitable for the treatment of S. typhi infections in these hospitals.

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Section: Resultsmentioning

confidence: 99%

Section: Figure 2: Antimicrobial Susceptibility Patterns Of S Typhi mentioning

confidence: 99%

Untitled

2014

IJPSR

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“…Ainsi, des souches hautement résistantes à la ciprofloxacine (CMI ≥ 4 mg/l) originaires du sous-continent indien ont été identifiées ; elles restent toutefois rares puisqu'elles ne représentaient que 0,2 % (5 sur 2016) des souches isolées aux États-Unis entre 1999 et 2006 [25,26,32,33]. Une seule souche de ce type a été identifiée en France depuis 1997.…”

Section: La Résistance Aux Antibiotiques De Demainunclassified

“…Une seule souche de ce type a été identifiée en France depuis 1997. Ces souches dérivent des souches Nal R -Cip SD par acquisition de mutations chromosomiques additionnelles (une deuxième mutation dans le gène gyrA et une mutation dans le gène parC codant pour une sous-unité de la topoisomérase IV, cible secondaire des quinolones) [32] ou bien par acquisition d'un gène plasmidique de résistance aux quinolones appelé qnr [33]. En dehors du problème thérapeutique qu'elles posent (aucune fluoroquinolone ne peut être active), ces souches ne présentent pas de difficulté d'identification au niveau du laboratoire contrairement aux souches Cip SD .…”

Section: La Résistance Aux Antibiotiques De Demainunclassified

La fièvre typhoïde n’est plus aussi simple à soigner

Weill

2010

Med Sci (Paris)

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“…Mutation at the conserved Ser84 in parC was documented in many bacterial species to cause quinolone resistance (4,8). Moon et al reported that a mutation at codon 84 in parC, combined with mutations in gyrA at codons 83 and 87, led to high levels of resistance to fluoroquinolones in 10 E. coli isolates (8).…”

mentioning

confidence: 99%