Cinnamaldehyde—A potential antidiabetic agent

Babu, P. Subash; Prabuseenivasan, Seenivasan; Ignacimuthu, Savarimuthu

doi:10.1016/j.phymed.2006.11.005

Cited by 352 publications

(125 citation statements)

References 33 publications

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“…On the other hand, treatment of the diabetic rats with N. sativa oil caused reduction in the activity of these enzymes in blood compared to the mean values of diabetic group and consequently may alleviate liver damage caused by STZ-induced diabetes. These results are in agreement with those obtained by [9] who reported that oral administration of cinnamaldehyde for 45 days significantly restores the enzyme levels to near normal in diabetic rats. A possible explanation for the differential effects of N. sativa oil on the activities of AST and ALT in blood is that these treatments may inhibit the liver damage induced by streptozotocin [2].…”

Section: Discussionsupporting

confidence: 93%

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Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Al-Logmani¹,

Zari²

2011

JDM

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The long-term effects of Nigella sativa L. oil on some physiological parameters were investigated in normal and streptozotocin (STZ)-induced diabetic male Wistar rats. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein (LDL-cholesterol), uric acid, urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) while high density lipoprotein (HDL-cholesterol) and total protein levels were significantly decreased compared to normal rats. Administration of black seed oil to diabetic rats resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL-cholesterol ALT, AST and uric acid while HDL-cholesterol level was markedly increased compared to untreated diabetic rats after seven weeks of treatment. The results of this study indicate that the diet containing the oil of N. sativa improves the examined physiological parameters in STZ-induced diabetic rats especially when it is used for a longer period.

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Section: Discussionsupporting

confidence: 93%

“…Also a number of plants have a hypolipidemic effect [8]. However, there is little information about plants with both hypoglycemic and hypolipidemic effects [9].…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Al-Logmani¹,

Zari²

2011

JDM

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“…Decrease in body weight of diabetic rats is due to catabolism of fats and proteins. Due to insulin deficiency the protein content is decreased in muscular tissue by proteolysis 28 . On oral administration of TG prevented the loss of body weight, excess of food intake in diabetic rats by controlling the hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Modulatory Effect of an Isolated Triglyceride from Fenugreek Seed Oil on of α-Amylase, Lipase and ACE Activities, Liver-Kidney Functions and Metabolic Disorders of Diabetic Rats

et al. 2017

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“…In addition to its culinary uses, cinnamon has been used in traditional herbal medicine to treat different health conditions (Gruenwald et al, 2010). Some studies showed that cinnamon extracts and its constituents also effective in the treatment of cancer (Nishida et al, 2003), insecticidal (Yang et al 2005), hypotensive (Preuss et al, 2006), antioxidant and antimutagenic activities (Jayaprakasha et al, 2007), cholesterol-lowering effects (Subash Babu et al, 2007), antimicrobial action (Carmo et al, 2008) and anti-inflammatory effect (Tung et al, 2008). The liver is the largest internal organ in the body and played a very important role in the detoxification of harmful and toxic substances.…”

Section: Introductionmentioning

confidence: 99%

Paracetamol induced hepatic toxicity and amelioration by cinnamon in rats

Elkomy¹,

Aboubakr

Soliman³

et al. 2016

IJPT

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The study was designed to evaluate the hepato-protective activity of aqueous extract of cinnamon in acute experimental liver injury induced by paracetamol. Twenty four male albino rats were randomly divided into four groups (six rats in each). Group I rats received distilled water for 15 days and served as a vehicle control. The animals in the group II were given single oral administration of paracetamol (1 g/kg), 1 h after last distilled water administration and acts as paracetamol toxic control group. Groups III and IV received aqueous extract of cinnamon (200 and 400 mg/kg bwt), respectively, once daily for 15 consecutive days followed by a single oral administration of paracetamol (1 g/kg), 1 h after the last cinnamon dose administration. The degree of hepatoprotection was measured using liver enzymes (Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. Also, histopathological examinations of liver were done. The significantly disturbed liver functions by paracetamol toxicity were restored to nearly normal values by administration of cinnamon. Also, the change in biochemical parameters in groups received paracetamol alone was modified towards the normal values in groups given paracetamol and cinnamon. Histopathological effect of paracetamol on liver was also markedly decreased by co-administration of cinnamon. Our findings concluded that cinnamon aqueous extracts possessed hepatoprotective activity against paracetamol induced hepatic toxicity in rats.

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Cinnamaldehyde—A potential antidiabetic agent

Cited by 352 publications

References 33 publications

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Modulatory Effect of an Isolated Triglyceride from Fenugreek Seed Oil on of α-Amylase, Lipase and ACE Activities, Liver-Kidney Functions and Metabolic Disorders of Diabetic Rats

Paracetamol induced hepatic toxicity and amelioration by cinnamon in rats

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