Cingulate Kindling in Senegalese Baboons, <i>Papio papio</i>

Wada, Juhn A.; Tsuchimochi, Hirohito

doi:10.1111/j.1528-1157.1995.tb00474.x

Cited by 17 publications

(10 citation statements)

References 42 publications

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“…This is followed by postictal visual searching behavior after stimulation of the cingulate cortex (19). In our patient, staring with widening of the eyelids is a prominent manifestation of his seizure semiology compatible with an anterior cingulate seizure focus.…”

Section: Discussionmentioning

confidence: 49%

Anterior Cingulate Gyrus Epilepsy: The Role of Ictal rCBF SPECT in Seizure Localization

et al. 2000

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Summary:Purpose: The goal of this report is to demonstrate the utility of ictal brain single photon emission tomography (SPECT) in a 39-year-old man with complex partial seizures arising from the anterior cingulate gyrus. Seizures originating from the anterior cingulate gyrns are difficult to localize because they have variable ictal semiology, are usually brief, and have rapid cortical propagation.Methods: Clinical neurologic examination, electroencephalography, extended video-electroencephalography with scalp and sphenoidal electrodes, magnetic resonance imaging, computed tomography, and ictal brain SPECT with Tc-99m HMPAO were performed to identify the seizure focus. The patient's regional cerebral blood flow (KBF) findings were compared with those of eight normal controls, and changes in rCBF were assessed by comparing the patient's ictal scan with those of normal controls at rest by using statistical parametric mapping (SPM).Results: Clinical and neurologic evaluations failed to demonstrate the epileptogenic focus. Ictal rCBF brain SPECT showed a focal region of hyperperfusion in the anterior cingulate gyrus. By using SPM, the ictal blood flow increase in the right anterior cingulate gyrus (x, y, z, -6, 42, 24 mm) was found to be statistically significant when compared with nomial controls (1, score, 4.88, p < 0.001). Subdural EEG recordings with intracranial electrodes positioned over this location confirmed that the cingulate gyms was the origin of the seizures, and surgical resection resulted in >90% seizure reduction.Conclusions: We concluded that ictal brain SPECT localization in conjunction with subdural electrode confirmation is a useful test in the presurgical evaluation of difficult to localize cingulate epilepsy. Key Words: Epilepsy-Cingulate-Ictal brain SPECT-MN-Tc-99m HMPAO-SPM.The temporal lobe is the most common site of intractable partial seizures that can be treated successfully with surgery (1,2). Extratemporal brain resections, especially for seizures of frontal and central origin, are less often performed because of difficulty in localization. Frontal lobe epileptogenic foci present a particular challenge in localization for surgical ablation because of their brief duration and the rapid propagation of seizure discharges (3). Many of these seizures, despite being frequent, are very difficult to capture by ictal single photon emission computed tomography (SPECT) studies because of their brevity (4). However, accurate evaluation of seizure onset through evaluation of the video-EEG assists in the

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Section: Discussionmentioning

confidence: 49%

Anterior Cingulate Gyrus Epilepsy: The Role of Ictal rCBF SPECT in Seizure Localization

et al. 2000

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“…Wada and Tsuchimochi kindled the posterior cingulate cortex in the Senegalese baboon Papio papio producing nonconvulsive seizures characterized by staring [12]. The ictal discharge in these animals was lateralizing to the kindled hemisphere.…”

Section: Discussionmentioning

confidence: 99%

Analysis of dynamics and propagation of parietal cingulate seizures with secondary mesial temporal involvement

Koubeissi¹,

Jouny²,

Blakeley³

et al. 2009

Epilepsy & Behavior

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SummaryCingulate onset seizures, particularly those originating from parietal cingulate regions are inadequately described and confounded by patterns of propagation. We analyzed scalp and depth electrode recordings in a patient whose seizures originated from a lesion in the right posterior cingulate region and produced secondary seizure activity in ipsilateral mesial temporal structures. Analyses included the matching pursuit (MP) method of time-frequency decomposition and the Gabor atom density (GAD) measure of signal complexity. Although scalp recordings suggested a right temporal onset, seizures recorded with depth electrodes clearly began in the parietal cingulate region before producing a secondary discharge in ipsilateral mesial structures. GAD revealed a significant increase of complexity during ictal cingulate activity and a consistent pattern of subsequent complexity changes in the hippocampus 30 seconds later. MP and GAD measures were valuable supplements to confirm the stereotyped pattern of both time-frequency changes and complexity. This provides additional evidence for pathways between the parietal cingulate region and mesial temporal structures and raises questions as to whether parietal cingulate seizures can produce clinical symptoms independent of regional or remote propagation.

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“…Development of stage 1 was more rapid at the AC than at the PC, indicating that the former has easier access to the anatomic substratum for smooth contralateral head turning. As in the previous primate study (8), kindling evolution was tardy, with the failure of progression beyond stage 1 in two animals (AC#992 and PC#996), whereas a stage 3 convulsive evolution and then stage 4 generalization were swift once stage 2 jerky contraversion and circling developed. The findings suggest that (a) the CG does not have a ready access to the motor mechanism responsible for convulsive evolution, (b) a significant role is played by the jerky contraversive mechanism in initiating convulsive evolution and generalization, and (c) the CG can support nonconvulsive seizures.…”

Section: Primary-site Cingulate Kindlingmentioning

confidence: 64%

“…At secondary-site kindling, some negative or interference effect can occur (17). However, enduringly sustained inhibition of kindling at the homotopic secondary site as observed in kindling of primate species (3,(6)(7)(8) has not been reported in any other species. Results of the present study now support our hypothesis that it is not a primate species-specific effect and occurs also in feline species.…”

Section: Secondary-site Kindling Inhibitionmentioning

confidence: 99%

Lasting Secondary Antiepileptogenesis Induced by Cingulate Kindling

Wada

Hirayasu

2004

Epilepsia

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Summary:Purpose: To test the validity of a hypothesis that kindling-induced enduring kindling inhibition of the homotopic secondary site is not a primate species-specific effect but occurs also in feline species.Methods: Five mature male cats were kindled at the anterior (AC) and posterior (PC) cingulate cortex followed by secondarysite kindling and primary-site retest.Results: Kindling was characterized by a marked seizure-stage instability and a progressive afterdischarge threshold elevation in all the animals. A protracted nonconvulsive seizure stage was followed by convulsive evolution and rapid generalization. At the secondary site, positive transfer effect was absent, and kindling did not occur. Primary-site retest activated kindled seizure within three stimulations. Recurrent spontaneous seizures, identical to the primary-site kindled seizure, occurred in two AC-kindled animals. Subsequent to this, a markedly elevated afterdischarge threshold also was found at some distant cortical and subcortical sites, to which the afterdischarge propagated. Kindling of the amygdala ipsilateral to the kindled AC or PC was tardy, with no positive transfer effect. However, it was associated with afterdischage threshold reduction.Conclusions: Cingulate kindling-induced enduring kindling inhibition at a homotopic secondary site is not a primate speciesspecific effect and occurs also in feline species. It is not limited to a homotopic site and represents a lasting secondary antiepileptogenesis, presumably due to enhanced intrinsic inhibitory mechanism(s) available to the mammalian brain. A selective afterdischarge threshold elevation concurrently observed is suspected to be a feline species-specific effect.

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Cingulate Kindling in Senegalese Baboons, Papio papio

Cited by 17 publications

References 42 publications

Anterior Cingulate Gyrus Epilepsy: The Role of Ictal rCBF SPECT in Seizure Localization

Anterior Cingulate Gyrus Epilepsy: The Role of Ictal rCBF SPECT in Seizure Localization

Analysis of dynamics and propagation of parietal cingulate seizures with secondary mesial temporal involvement

Lasting Secondary Antiepileptogenesis Induced by Cingulate Kindling

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