Cimetropium Bromide in the Treatment of Crisis in Infantile Colic

Savino, Francesco; Brondello, Cristina; Cresi, Francesco; Oggero, R; Silvestro, Leandra

doi:10.1097/00005176-200204000-00020

Cited by 50 publications

(47 citation statements)

References 21 publications

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“…40 The effects of motilin are inhibited by atropine, which may explain why atropine and similar anticholinergic compounds ameliorate colic symptoms. 41,42 It is unclear whether food proteins are able to stimulate endogenous motilin secretion either directly or indirectly, through immune-mediated mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Low-Allergen Maternal Diet on Colic Among Breastfed Infants: A Randomized, Controlled Trial

et al. 2005

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ABSTRACT.Background. There is controversy regarding whether hypersensitivity to food proteins contributes to colic among breastfed infants.Methods. A randomized, controlled trial of a lowallergen maternal diet was conducted among exclusively breastfed infants presenting with colic. In the active arm, mothers excluded cow's milk, eggs, peanuts, tree nuts, wheat, soy, and fish from their diet; mothers in the control group continued to consume these foods. Outcomes were assessed after 7 days, as the change in cry/fuss duration over 48 hours, with validated charts. The primary end point was a reduction in cry/fuss duration of >25% from baseline. Mothers also assessed the responses to diet with categorical and visual analog scales.Results. Of 107 infants, 90 completed the trial (mean age: 5.7 weeks; range: 2.9 -8.6 weeks; 54 male infants). Infants in both groups presented with significant distress (geometric mean: low-allergen group: 690 minutes per 48 hours; control group: 631 minutes per 48 hours). In follow-up assessments on days 8 and 9, there were significantly more responders in the low-allergen group (74% vs 37%), ie, an absolute risk reduction of 37% (95% confidence interval: 18 -56%). Cry/fuss duration per 48 hours was reduced by a substantially greater amount in the low-allergen group; the adjusted geometric mean ratio was 0.79 (95% confidence interval: 0.63-0.97), ie, an average reduction of 21% (95% confidence interval: 3-37%). Mothers' subjective assessments of the responses to diet indicated little difference between the groups.Conclusion. Exclusion of allergenic foods from the maternal diet was associated with a reduction in distressed behavior among breastfed infants with colic presenting in the first 6 weeks of life.

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Section: Discussionmentioning

confidence: 99%

Effect of a Low-Allergen Maternal Diet on Colic Among Breastfed Infants: A Randomized, Controlled Trial

et al. 2005

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“…Cimetropium bromidin yan etkileri olabileceğinden kullanılması önerilmemektedir (35) . Proton pomba inhibitörlerinin de ağlama üzerine etksinin plasebodan farklı olmadığı bildirilmiştir (36) .…”

Section: İlaçlarunclassified

New looking to the old problem: Infantile Colic

Karabayır¹,

Gökçay²

2017

Cocuk Dergisi

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“…Полученные результаты показали, что применение последнего препарата было ассоции-ровано с высокой частотой вестибулопатии и/или сон-ливости [24]. Ряд авторов полагает, что симетикон по эффективности не отличался от плацебо [41].…”

Section: лечениеunclassified

“…Современная концепция уменьшения болевого син-дрома при коликах сводится к его пошаговой коррекции [41]. В идеологию «шаговой» терапии заложен путь от более простых мероприятий к более сложным, что позво-ляет или купировать функциональные кишечные колики, или выявить наличие патологического процесса у ребенка («тревожные сигналы»).…”

Section: лечениеunclassified

Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children

Броева¹,

Сурков²,

Chernikov³

2017

Pediatr. farmakol.

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Cimetropium Bromide in the Treatment of Crisis in Infantile Colic

Abstract: Cimetropium bromide was more effective than placebo in reducing the duration of crying in children with infantile colic. The use of the anticholinergic drugs, aside from the dicyclomine because of its dangerous side effects, should be revaluated for treating infantile colic.

Cited by 50 publications

References 21 publications

Effect of a Low-Allergen Maternal Diet on Colic Among Breastfed Infants: A Randomized, Controlled Trial

Effect of a Low-Allergen Maternal Diet on Colic Among Breastfed Infants: A Randomized, Controlled Trial

New looking to the old problem: Infantile Colic

Current Issues of Diagnosis and Treatment of Functional Gastrointestinal Disorders in Children

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