Cimetidine therapy for recalcitrant warts in adults

Glass, A. T.

doi:10.1001/archderm.132.6.680

Cited by 22 publications

(17 citation statements)

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“…Other adjuvant medical therapies that have shown efficacy against RRP include acyclovir, methotrexate, ribavirin, cimetidine, 80,81 and, more recently, cidofovir. 74,[82][83][84] Cidofovir is a approved by the U.S. Food and Drug Administration for cytomegalovirus retinitis in individuals with autoimmune deficiency syndrome (AIDS).…”

Section: Role Of Adjuvant Medical Therapy For Pediatric Recurrent Resmentioning

confidence: 99%

Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric Population

et al. 2004

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Statistical analysis of the relationships among epidemiological factors, HPV type, and clinical course revealed that patients with HPV-11 and patients younger than 3 years of age at RRP diagnosis are prone to develop more aggressive disease as represented by higher severity scores at endoscopic debridement, more frequent operative debridement procedures per year, a greater requirement for adjuvant therapy, and greater likelihood of tracheal disease with tracheotomy.

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Section: Role Of Adjuvant Medical Therapy For Pediatric Recurrent Resmentioning

confidence: 99%

Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric Population

et al. 2004

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“…H 2 -antagonists, especially cimetidine, are known to enhance immune responses and showed promising therapeutic outcomes with an estimated 48-81% response rate in open-label studies. [2][3][4][5] However, subsequent randomized controlled trials (RCT) failed to show significant efficacy when cimetidine was compared with placebo or topical agents. [6][7][8] Recently, oral zinc sulfate showed outstanding therapeutic efficacy with an estimated 62.5-86.9% complete response rate in three RCT and one double-blind prospective study in which it was compared with cimetidine.…”

Section: Introductionmentioning

confidence: 99%

Oral zinc sulfate treatment for viral warts: An open-label study

Mun

Kim

Jung

et al. 2010

The Journal of Dermatology

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Viral warts, which are caused by the human papilloma virus, are a common problem in dermatology. Various modalities have been used to treat warts, but none are uniformly effective or directly antiviral. Recent studies show that oral zinc sulfate could be effective in the treatment of viral warts. Thirty-one patients with multiple, non-genital viral warts were recruited in this open-label clinical study. The patients were treated with oral zinc sulfate (10 mg/kg to a maximum dose of 600 mg/day) for 2 months and followed up with assessments for the resolution of their warts and for any evidence of recurrence after treatment. Among the 31 patients, 18 patients showed low serum zinc levels (58%). Of 26 patients who completed the study (84%), 13 (50%) showed complete resolution of their warts after 2 months of treatment. Complete responders remained free of lesions at 6-month follow-up. No serious side-effects were reported apart from nausea (16%), mild gastric pain (3%) and itching sensation (3%). Oral zinc sulfate was found to be a good option in the treatment of viral warts, as it was safe and effective without important side-effects.

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“…Various immunomodulating agents have been used in the treatment of recalcitrant warts. Cimetidine, a histamine (H 2 ) receptor antagonist, which has been shown to possess immunomodulatory activity at high dosages, was used in the treatment of multiple warts with successful results by Glass and Solomon 1 . Results of subsequent studies by Bauman et al 2 .…”

Section: To the Editormentioning

confidence: 99%

“…In common warts the lesions were measured at the widest diameter. The response was graded according to the system used by Glass and Solomon: 1 complete response, partial response (more than 50% reduction in the size and/or number of lesions), minimal response (less than 50% reduction in the size and/or number of lesions), stable disease and disease progression.…”

Section: To the Editormentioning

confidence: 99%