Cilostazol-induced relaxation of calf cardiac vein and coronary artery during cooling

Ke, Nurullahoğlu-Atalık; Zu, Nurullahoglu; Kılıç, Mustafa; Arıbaş, Alpay

doi:10.4149/bll_2013_117

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…In this work, we studied the effects of moderate hypothermia on calcium channel blockersinduced vasodilatation of calf cardiac vein, paying special attention to the role of nitric oxide in these responses. The calf cardiac vein is an easily accessible smooth muscle preparation and there is limited information (12,19,20) about the effects of temperature in non-cutaneous vessels. Moreover, the effects of hypothermia were generally studied with contractile agents.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the previous studies examining the effect of hypothermia on smooth muscle responses have focused on the effects of cutaneous vessels (13,17,23) and information about non-cutaneous vessels is rather limited. Previously, we investigated the effects of hypothermia on diazoxide-(2) and cilostazol-induced (19) relaxations in calf cardiac vein and coronary artery.…”

Section: Introductionmentioning

confidence: 99%

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Moderate hypothermia and responses to calcium channel blockers – Role of the nitric oxide

Canbolat

Atalık

2018

Acta Physiol Hung

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Moderate hypothermia (25-31 °C) may have a significant influence on vascular tone. At present, very little is known about the role of endothelial nitric oxide on the hypothermia-induced responses. In this study, we investigated the effect of hypothermia (to 28 °C) on the vasodilatation induced by verapamil, a phenylalkylamine calcium channel blocker (10-3 × 10 M) and dihydropyridines, amlodipine (10-3 × 10 M), and benidipine (10-10 M) on 5-hydroxytryptamine (5-HT or serotonin) precontracted calf cardiac veins. Furthermore, the role of nitric oxide in the hypothermia-induced responses was analyzed. Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 15 ml of Krebs-Henseleit solution, maintained at 37 °C, and continuously gassed with 95% O-5% CO. After a resting period, verapamil, amlodipine, and benidipine were applied cumulatively on serotonin (10 M) precontracted calf cardiac vein rings and induced concentration-dependent relaxations. In another part of the study, the medium temperature was decreased to 28 °C after the preparations were contracted with 5-HT, then cumulative concentrations of verapamil, amlodipine, or benidipine were added. During hypothermia, the pIC value, but not the maximal response, to all blockers were significantly higher than at 37 °C. Hypothermia in the presence of N-nitro-l-arginine methyl ester (L-NAME, 10 M) decreased the pIC and E values to verapamil, amlodipine, and benidipine. Only one blocker was tested in each preparation. These results suggest that nitric oxide may play a role in the hypothermia-induced changes in vasodilation caused by verapamil, amlodipine, and benidipine in calf cardiac vein, but further research is needed to explain the complete mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Moderate hypothermia and responses to calcium channel blockers – Role of the nitric oxide

Canbolat

Atalık

2018

Acta Physiol Hung

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“…Alginate dressing has extreme strong absorbance ability, and it can absorb almost 20 times fluid of its weight, which assures the moisture environment of wound healing, and extends dressing time, and in the meantime it can make the autolysis of necrotic tissue in the wound. Furthermore, calcium ion of alginate can form a reticular layer of gel at the wound surface which is helpful in enhancing haemostasis [7,12]. Therefore, Alginate dressing was used in local haemostasis after surgical operation and haemostasis of burning skin implantation in recent years, which uses characteristics of haemostasis, absorbing bleeding, keep moisture environment of cut surface to enhance wound healing.…”

Section: Discussionmentioning

confidence: 99%

Alginate Dressing Application in Hemostasis After Using Seldinger Peripherally Inserted Central Venous Catheter in Tumor Patients

Yang

Lei

2014

Indian J Hematol Blood Transfus

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The aim of this study is to observe hemostatic effects of alginate dressing after using seldinger PICC catheter in tumor patients. Sixty tumor patients with PICC receiving chemotherapy were divided into the test group (30 cases) and the control group (30 cases) randomly. The test group was treated with alginate dressing and oppressed by the puncture point, while the control group was treated with gauze of the same size. PICC transparent films were used in both groups. Finally, dressing ooze blood soaked states on the puncture points and dressing change times were observed in the two groups for 1 week. Moreover, local infection rate and incidence of catheter leak were also evaluated. The results showed that the oozing of blood and the changing frequency in the test group were obviously less than that in the control group, and there has a statistical difference (P < 0.05). Infection rate of puncture point and incidence of catheter leak were simultaneously reduced in the test group. Alginate dressing is effective in preventing seldinger PICC catheter-induced hemorrhage.

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Cilostazol-induced relaxation of calf cardiac vein and coronary artery during cooling

Cited by 2 publications

References 24 publications

Moderate hypothermia and responses to calcium channel blockers – Role of the nitric oxide

Moderate hypothermia and responses to calcium channel blockers – Role of the nitric oxide

Alginate Dressing Application in Hemostasis After Using Seldinger Peripherally Inserted Central Venous Catheter in Tumor Patients

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