Ciliary Neurotrophic Factor Enhances Peripheral Nerve Regeneration

Ciliary Neurotrophic Factor Improves Nerve Conduction and Ameliorates Regeneration Deficits in Diabetic Rats

“…CNTF treatment restored toe spread in diabetic rats to normal, consistent with this neurotrophic factor's influence on the development and function of synapses (36) and the previously reported ability to enhance functional recovery after nerve transection (37). The lack of an effect of 3 per group).…”

Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons

“…To date the trophic actions of gp130 cytokines has been mainly confined to regeneration within the injured motor system (Arakawa et al, 1990;Sahenk et al, 1994;Ulenkate et al, 1994;Hirota et al, 1996;Newman et al, 1996;Tham et al, 1997;Zhong et al, 1999). Our current study now provides evidence that LIF is a cornerstone for regeneration of small-diameter sensory axons.…”

Simultaneous Treatment With BDNF and CNTF After Peripheral Nerve Transection and Repair Enhances Rate of Functional Recovery Compared With BDNF Treatment Alone

“…The results of this study and previous studies in our laboratory 13,20 suggest that the activity of both BDNF and CNTF that was actually delivered to the neurorrhaphy were maintained in vivo, however neurotrophic factor activity was not assayed in this experiment.…”

“…Although not statistically significant, these data suggest a trend that correlates with functional recovery. A previous investigation in our laboratory using CNTF alone demonstrated significant functional improvement and conservation of muscle mass over control using twice the concentration of CNTF (300 μg/mL) with an endpoint of 60 days 13 . These different conditions may be critical as the myotrophic activity of CNTF acts in a dose dependent fashion that decreases over time 18 .…”