Cigarette smoking by women: interactions with alcohol use

Mello, Nancy K.; Mendelson, Jack H.; Palmieri, Susan L.

doi:10.1007/bf02439579

Cited by 94 publications

(60 citation statements)

References 24 publications

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“…It is possible that those with greater nicotine dependence were more reactive to tobacco following alcohol consumption. Studies of light, social drinkers have demonstrated either minimal (Henningfield et al, 1984) or modest increases in smoking behavior following alcohol consumption (Mello et al, 1987), suggesting that the influence of drinking on smoking behavior may be more pronounced in heavier drinkers. In addition to our stated focus on understanding lapse behavior in abstaining smokers, this study may also have relevance for understanding the influence of alcohol on ongoing smoking behavior in those not attempting cessation.…”

Section: Discussionmentioning

confidence: 99%

Modeling the effect of alcohol on smoking lapse behavior

et al. 2006

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The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacco relapse: 1) Does alcohol facilitate the initiation of the first cigarette? 2) Once the first cigarette is initiated, does alcohol facilitate subsequent smoking? Using a within-subject design, 16 daily smokers who were also heavy social drinkers received a priming drink (0.03 g/dl or taste masked placebo) and then had the option of initiating a tobacco self-administration session or delaying initiation by five minute increments for up to 50 minutes in exchange for monetary reinforcement. Subsequently, the tobacco self-administration session consisted of a one-hour period, in which subjects could choose to smoke their preferred brand of cigarettes using a smoking topography system or receive monetary reinforcement for cigarettes not smoked. Alcohol craving, tobacco craving, subjective reactivity to alcohol, and nicotine withdrawal were assessed as secondary outcomes. Results demonstrated that after consuming the alcohol beverage, subjects were less able to resist the first cigarette and initiated their smoking sessions sooner, and smoked more cigarettes compared to the placebo beverage. These findings have implications for smoking cessation in alcohol drinkers and model development to assess smoking lapse behavior. Keywordssmoking; lapse behavior; alcohol; craving; human laboratory; monetary reinforcement It is well established that alcohol consumption and tobacco use are highly correlated in both clinical and non-clinical samples. Among alcoholics, 80% to 95% are smokers (DiFranza & Guerrera, 1990;Hughes, 1993;Kalman et al., 2005;Patten et al., 1996;Sobell et al., 1990), as compared to 23% in the general population (CDC, 2003 (DiFranza & Guerrera, 1990;Grant et al., 2004;Hurt et al., 1994) and the severity of alcohol and tobacco dependence is positively correlated (Ellingstad et al., 1999;Gulliver et al., 1995). Smoking is also highly correlated with drinking in nonalcoholic individuals (Carmody et al., 1985;Istvan & Matarazza, 1984), particularly among those who are heavy drinkers. Both laboratory studies and naturalistic observations have demonstrated that alcohol consumption is strongly associated with increased rates of smoking (Glautier et al., 1996;Mitchell et al., 1995;Shiffman et al., 1994). Additionally, there is evidence for cross-substance craving from both clinical and non-clinical samples (Drobes et al., 2000;Tiffany, 1995). Given the high co-occurrence of alcohol and tobacco use, it is not surprising that alcohol has been identified as a risk factor for poor smoking cessation outcomes (Baer & Lichenstein, 1988;Shiffman 1986;Zimmerman et al., 1990). For example, Shiffman (1986) found that 20% of all relapse episodes in smokers involved alcohol consumption. In a real-time examination of first lapse episodes, ...

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Section: Discussionmentioning

confidence: 99%

Modeling the effect of alcohol on smoking lapse behavior

et al. 2006

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“…Human laboratory studies have examined the effect of smoked tobacco on alcohol use (Barrett et al 2006;Madden et al 1995;Mello et al 1980Mello et al , 1987 as well as the effect of nicotine deprivation on the reinforcing value of alcohol (Colby et al 2004;Cooney et al 2003;Palfai et al 2000;Perkins et al 2000a). Fewer studies have tested the effect of nicotine replacement on subjective alcohol responses (Cooney et al 2001;Kouri et al 2004;Perkins et al 1995) and alcohol self-administration behavior (Acheson et al 2006).…”

Section: Introductionmentioning

confidence: 99%

“…For the current study, we were interested in examining the effect of transdermal nicotine replacement on subjective and physiological responses to a low-dose priming drink of alcohol and subsequent self-administration behavior in a sample of heavy-drinking daily smokers. While alcohol-nicotine interactions have been documented in lighter users (e.g., Barrett et al 2006), it has been suggested that the nature of these interactions may be more pronounced in those with heavier use (e.g., Henningfield et al 1984;Mello et al 1987). We enrolled individuals with heavier patterns of alcohol and cigarette use (15-25 cigarettes per day; at least nine drinks per week for females; at least 12 drinks per week for males) than the Acheson et al (2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration

et al. 2007

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Rationale-Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior.Objective-The primary aim of this within-subject, double-blind study was to examine whether transdermal nicotine replacement (0 mg vs 21 mg/day) altered response to a low-dose priming drink and subsequent ad libitum drinking behavior.Materials and methods-Subjects (n=19) were non-treatment-seeking, non-dependent heavy drinkers who were daily smokers. Six hours after transdermal patch application, subjective and physiological responses to a priming drink [designed to raise blood alcohol levels (BALs) to 0.03 g/ dl] were assessed. This was followed by a 2-h self-administration period where subjects could choose to consume up to eight additional drinks (each designed to raise BALs by 0.015 g/dl) or to receive monetary reinforcement for drinks not consumed.Results-We found that 6 h after patch application, tobacco craving associated with withdrawal relief was decreased, and systolic blood pressure and heart rate were increased in the active patch condition compared to the placebo patch condition. Subjective intoxication in response to the priming drink was attenuated in the active nicotine patch condition compared to 6 h of nicotine deprivation (i.e., placebo patch). During the self-administration period, subjects had longer latencies to start drinking and consequently appeared to consume fewer drinks when administered the active patch compared to the placebo patch.Conclusions-In heavy drinkers, transdermal nicotine replacement compared to mild nicotine deprivation attenuated subjective and physiological alcohol responses and delayed the initiation of drinking.

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“…Nonalcoholic women with premenstrual symptoms have been shown to increase their alcohol consumption premenstrually under controlled laboratory conditions (Mello et al 1990). Women with premenstrual symptoms have also been shown to smoke more marijuana or tobacco cigarettes premenstrually, suggesting that this subpopulation of women may be at increased risk to use a variety of drugs (Mello and Mendelson 1985;Mello et al 1987). Thus, a second purpose of this study was to determine if women who suffered from PMS were at risk to misuse or abuse benzodiazepines.…”

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confidence: 99%