Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy

Nio‐Kobayashi, Junko; Abidin, Hazirah B. Z.; Brown, Jeremy K.; Iwanaga, Toshihiko; Horne, Andrew; Duncan, W. Colin

doi:10.1002/mrd.22747

Cited by 10 publications

(8 citation statements)

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“…The pathogenesis is still not clear. The known risk factors include reduced or impaired tubal transport activity, increased tubal receptivity for blastocyst implantation, tubal damage due to surgery or infection, in vitro fertilization, and cigarette smoking [ 13 , 14 ]. REP is very rare with a total of less than 20 cases reported in the English literature [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal ectopic pregnancy: a case report and review of the literature

Yang

Cidan

Zhang

2017

BMC Pregnancy Childbirth

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BackgroundRetroperitoneal ectopic pregnancy (REP) is an extremely rare type of ectopic pregnancy, with a total of less than 20 cases reported in the English literature. However, failure to recognize REP may result in severe consequences.Case presentationWe report a case of 32-year-old woman with REP. She had amenorrhea, left lower abdominal pain, but no vaginal bleeding. Her urine human chorionic gonadotropin (HCG) test was positive and blood HCG level was 1880 m-international units per milliliter (mIU/mL). Transvaginal ultrasound sonography showed a left adnexal mass. Laparoscopy found an enlarged uterus, normal right uterine tube and ovary, and normal left uterine tube. The left ovary was partly covered by a blood clot, but appeared normal after removing the clot. There was a 10-mm circular peritoneal defect located lateral to the left sacrocervical ligament, anterior to the left ovarian fossa, and next to the lower edge of the left broad ligament. The patient was diagnosed of having REP with the gestational tissues covered by the peritoneum. The REP was removed by laparoscopic surgery. Bleeding was stopped by bipolar coagulation and absorbable hemostatic cellulose. The patient recovered smoothly and was discharged on the next day after surgery. Her blood HCG returned to normal range 29 days after surgery.ConclusionsREP is very rare, but in any suspected case of ectopic pregnancy, caution must be paid to find signs of REP when the common sites of ectopic pregnancy do not have any positive findings.

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Section: Discussionmentioning

confidence: 99%

Retroperitoneal ectopic pregnancy: a case report and review of the literature

Yang

Cidan

Zhang

2017

BMC Pregnancy Childbirth

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“…A similar impact could be anticipated in older women, but the age limit of 38 years might have prevented us from observing this phenomenon. Although the interaction between treatment effect of oil-based contrast and smoking was not statistically significant, smokers have tubal damage and dysfunction induced by nicotine and other smoking-related chemicals, which may be related to more tubal debris and mucus plugs caused by abnormal ciliogenesis associated with smoking (Nio-Kobayashi et al , 2016, Shao et al , 2012).…”

Section: Discussionmentioning

confidence: 94%

Tubal flushing with oil- or water-based contrast medium: can we identify markers that indicate treatment benefit?

Rijswijk

Welie

Dreyer

et al. 2019

Human Reproduction Open

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STUDY QUESTION Can we identify patient characteristics that distinguish which ovulatory infertile women undergoing hysterosalpingography (HSG) benefit more or less from flushing with oil-based contrast medium compared to water-based contrast medium? SUMMARY ANSWER In ovulatory infertile women, HSG with oil-based contrast medium resulted in higher 6-month ongoing pregnancy and live birth rates as compared to HSG with water-based contrast medium and this treatment effect was independent of characteristics of the couple. WHAT IS KNOWN ALREADY We recently showed that in infertile women undergoing HSG, flushing with oil-based contrast medium resulted in more ongoing pregnancies than flushing with water-based contrast medium. STUDY DESIGN, SIZE, DURATION We used data from our randomized clinical trial (RCT) in which 1,119 ovulatory infertile women undergoing HSG during fertility work-up were randomized for use of oil-based (N = 557) or water-based (N = 562) contrast medium. PARTICIPANTS/MATERIALS, SETTING, METHODS We built logistic regression models to predict ongoing pregnancy and live birth (secondary outcome) as a function of the specific contrast, the specific marker, and marker-by-contrast-interaction. Markers considered were female age, maternal ethnicity, female smoking, body mass index (BMI), duration of infertility, infertility being primary or secondary, sperm quality, and previous appendectomy. MAIN RESULTS AND THE ROLE OF CHANCE The 6-month ongoing pregnancy rates in the overall population were 39.7% after use of oil-based contrast versus 29.1% after use of water-based contrast medium [relative risk (RR), 1.37; 95% confidence interval (CI), 1.16–1.61; P < 0.001]. Among the studied baseline characteristics, BMI (P = 0.002) and semen volume (P = 0.02) were statistically significant prognosticators. The treatment effect of oil-based contrast was stronger in women with a BMI ≤30 kg/m2 [RR, 1.54; 95% CI, 1.23–1.92; P = 0.002], and in women whose partner had a semen volume >3 ml [RR, 1.77; 95% CI, 1.28–2.46; P = 0.02]. Also, in women who smoked, the treatment effect of flushing with oil was stronger, but this interaction did not reach statistical significance (P = 0.066). We found no positive effect of oil-based contrast in obese women. We found similar but weaker associations for live birth, which was probably due to lower number of events resulting in less power. LIMITATIONS, REASONS FOR CAUTION The RCT was restricted to infertile ovulatory women younger than 39 years of age without endocrinological disorders and at low risk for tubal pathology. Our results should not be generalized to infertile women who do not share these features. WIDER IMPLICATIONS OF THE FINDINGS All infertile, ovulatory women younger than 39 years with a low risk for tubal pathology will benefit from an HSG with oil-based contrast; therefore, this should be offered to them after fertility work-up. STUDY FUNDING/COMPETING INTEREST(S) The original H2Oil RCT was an investigator-initiated study that was funded by the two academic institutions (AMC and VUmc) of the Amsterdam UMC. The study displayed in this paper was funded by an unconditional research grant from Guerbet. B.W.M. is supported by an NHMRC Practitioner Fellowship (GNT1082548). K.D. reports consultancy for Guerbet, during the conduct of the study, and also reports research grants from Guerbet. C.B.L. reports grants from Guerbet, during the conduct of the study, and grants from Ferring, grants from Merck, and personal fees from Ferring, outside the submitted work. P.H. reports grants from Guerbet, during the conduct of the study, and grants from Ferring and Merck, outside the submitted work. V.M. reports receiving travel and speakers fee as well as research grants from Guerbet. B.W.M. reports consultancy for ObsEva, Merck, Merck KGaA, and Guerbet, and research grants from Guerbet and Merck. The other authors have no conflict of interest to declare. TRIAL REGISTRATION NUMBER NTR 3270 www.trialregister.nl TRIAL REGISTRATION DATE 1 February 2012. DATE OF FIRST PATIENT’S ENROLMENT 3 February 2012.

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“…Similarly, few evidence demonstrated the pathological roles of sialylation in reproductive diseases. Nio-Kobayashi et al [50] explored that cigarette smoking altered a2,3and a2,6-sialylation in the fallopian tube epithelium, and was potentially a source of decreased tubal transport and with implications for the pathogenesis of ectopic pregnancy. In this study, we found that a2,3-sialylation was increased in RL95-2 cells and mouse uterine endothelium at PD4, which both represent a highly receptive status.…”

Section: Discussionmentioning

confidence: 99%

The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo

Wang

Liu

et al. 2018

FEBS Letters

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The receptive uterine endometrium specifically expresses certain glycosyltransferases, and the corresponding oligosaccharides play important roles in accepting the embryo. The sialyltransferase β-galactoside-α2,3-sialyltransferase III (ST3Gal3) is the key enzyme responsible for sialyl Lewis X (sLeX) oligosaccharide biosynthesis, but the expression and function of ST3Gal3 in the receptive endometrium is still elusive. Here, we found that human endometrial tissues at secretory phase expressed a 4-fold higher ST3Gal3 level relative to the tissues at proliferative phase. Meanwhile, downregulation of ST3Gal3 or sLeX epitope blockage significantly impaired the receptive ability of human endometrial RL95-2 cells to trophoblastic cells in vitro and inhibited implantation in pregnant mice. This study suggests that ST3Gal3 facilitates endometrial receptivity through increasing sLeX oligosaccharide, which gives a better understanding of the glycobiology of implantation.

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Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy

Cited by 10 publications

References 29 publications

Retroperitoneal ectopic pregnancy: a case report and review of the literature

Retroperitoneal ectopic pregnancy: a case report and review of the literature

Tubal flushing with oil- or water-based contrast medium: can we identify markers that indicate treatment benefit?

The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo

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