Cigarette Smoking, Alcohol Consumption and Overweight in Multiple Sclerosis: Disability Progression

Paz-Ballesteros, Wayra Citlali; Monterrubio‐Flores, Eric; Flores-Rivera, José; Corona, Teresa; Hernández–Girón, Carlos

doi:10.1016/j.arcmed.2017.03.002

Cited by 29 publications

(25 citation statements)

References 37 publications

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“…In a recent study, it was noted that the progression of the expanded disability scale score was faster in daily smokers than in non-smokers. 75 This effect on disease progression is assumed to be caused by a reduction in CD4 + , CD25 + , and other regulatory cells. This reduction is explainable by two pathways suggested in a recent study: I) increased production of IL-6 and IL-13, attributable to the decreased activity of indoleamine 2,3-dioxygenase, and II) Elevation in the expression and activity of the renin angiotensin system, inducing an increase in IL-17 and IL-22, resulting in the higher production of chemokines in smoking patients.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…This reduction is explainable by two pathways suggested in a recent study: I) increased production of IL-6 and IL-13, attributable to the decreased activity of indoleamine 2,3-dioxygenase, and II) Elevation in the expression and activity of the renin angiotensin system, inducing an increase in IL-17 and IL-22, resulting in the higher production of chemokines in smoking patients. 75 The association between cigarette smoking and disease progression in PPMS is not clarified yet. A recent study showed no effect exerted by smoking on disability accumulation in PPMS, suggesting that the disability progression in PPMS involves different underlying pathomechanisms from that in RRMS.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…102 Alcohol, Caffeine, and Nicotine In case of MS susceptibility, studies have manifested no association between alcohol consumption and increased MS risk. 103,104 Regarding the correlation of disease severity in RRMS patients with alcohol consumption, one recent study suggested that the cessation of alcohol consumption could potentially be beneficial, 75 and the results yielded an inverse association between drinking alcoholic beverages and the progression rate among patients diagnosed with SPMS. In PPMS patients, however, there was no association observed, 105 supporting the idea that different mechanisms are involved in the disability progression of PPMS and SPMS patients.…”

Section: Obesitymentioning

confidence: 99%

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Protective and Risk Factors in Multiple Sclerosis

et al. 2019

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Introduction Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system (CNS). Damage to myelin proteins occurs during MS progression and relapse. Over 2 million people suffer from the consequences of pathological mechanisms which MS involves, monocular visual loss, limb weakness/sensory loss, diplopia (double vision) and ataxia resulting from optic neuritis, transverse myelitis, brainstem dysfunction, and cerebellar lesions being among them. 1 Based on the disease course, MS patients can be divided into four main types: I) Relapsing-remitting MS (RRMS), which is by far the most common type, affecting about 85% of MS patients; II) Secondary progressive MS (SPMS), which may progress in patients with relapsingremitting MS; III) Primary progressive MS (PPMS); and IV) Progressive-relapsing MS (PRMS). 2 A recently detected subtype of the disease described as "myelocortical MS" argues against the idea that neural degeneration necessarily occurs following demyelination. In patients with myelocortical MS, demyelinated lesions in cerebral white matter were not observed. Similar to typical MS courses, however, the mean cortical neuronal densities were significantly lower than those of the healthy controls. 3 These new findings will further improve the diagnoses and treatments utilized in MS patients. Genetic Factors Human Leukocyte Antigen and microRNAs Genes The human leukocyte antigen (HLA)-DRB1 gene explains up to 10.5% of the genetic variance underlying risk. 4 HLA-DRB1*15:01 allele has the strongest association with increased MS risk among genetic risk factors and has been consistently associated with MS susceptibility in approximately all populations studied, pointing to a specific antigen presentation as the pathogenic mechanism. Based on previous studies, the association between MS and the HLA-DR15 haplotype (HLA-DRB1*15:01 allele and the alleles in linkage disequilibrium with it; HLA-DQB1*0602 and HLA-DQA1*0102) has been shown throughout both European and non-European populations, 5 except in Sardinian individuals, among whom MS susceptibility has been reported to be associated with HLA-DR4 (DRB1*0405, DQA1*0301, DQB1*0302) instead of HLA-DR15. 5-7 The association between HLA-DR2 and MS has been observed mostly among northern European populations. 8 A single vitamin D response element was identified in the HLA-DRB1 promoter region, advancing the idea of an interaction between vitamin D and HLA-DRB1. The role of this interaction in disease etiology has not been elucidated yet, but it can be hypothesized that a lack of vitamin D in early childhood can alter the expression levels of HLA

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Section: Environmental Factorsmentioning

confidence: 99%

Section: Environmental Factorsmentioning

confidence: 99%

Section: Obesitymentioning

confidence: 99%

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Protective and Risk Factors in Multiple Sclerosis

et al. 2019

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“…Smoking, alcohol consumption and obesity among others have been shown to associate with fast disease progression in different MS populations. [11][12][13][14]…”

Section: Introductionmentioning

confidence: 99%

Predictors of Multiple Sclerosis Severity Score in Patients with Multiple Sclerosis

Albatineh¹,

Alroughani²,

Al-Temaimi³

2020

International Journal of MS Care

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Background: Multiple sclerosis (MS) is a demyelinating autoimmune disorder. Several factors have been shown to associate with MS clinical severity. Here we investigated the influence of different life style factors on MS clinical severity as assessed by the MS severity score (MSSS). Methods: A questionnaire was administered to 128 Kuwaiti MS patients to assess the association of smoking, supplement use, food allergy, physical activity and education with MSSS. A multiple linear regression model was used to test for associations. Regression model results were adjusted for gender, history of blood transfusion, MS age of onset, and marital status. Results: Smoking status, passive smoking and food allergy are not associated with MSSS. MS patients with a college education and graduate/professional degrees have on average 2.56 lower MSSS scores compared to those with less than high school education (β = −2.22 PV = 0.045, and β = −2.9 PV = 0.048, respectively). Patients who perform physical activity score on average 2.32 lower on the MSSS compared to those with no physical activity (Moderate exercise PV = 0.003, rigorous exercise PV = 0.001). Physical activity correlated significantly with MSSS outcomes (r2 = 0.452, PV < 0.001). Conclusions: Physical activity and educational level are significantly associated with reduced MSSS. Physical activity and educational level both contribute to a less severe MS clinical course. Current MS management protocols should consider life style changes to improve the quality of life of MS patients.

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“…Los principales factores de riesgo relacionados a problemas de salud son el consumo de alcohol (54) y tabaco (55)(54) (56) , desequilibrio dietético, no practicar ejercicio físico (57)(56) , no participar en programas de promoción de la salud, las instrucciones médicas y utilizar de forma inadecuada de los servicios de salud (53) , estrés (58) y sueño.…”

Section: Estilos De Vida De Las Madres Saludableunclassified

Estilo de vida saludable de las madres y microbiota intestinal en neonatos prematuros de un hospital de Lima en el 2017

Rutti¹,

Natali²

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A mi madre Balvina Rutti Nestares, a quien debo ser profesional, mi ejemplo a seguir de bondad y lucha por crecer día a día. A Cecilia Burga Aldunce y Abelardo Cruces, mis segundos padres, mis ángeles en esta tierra, gracias por velar siempre por mí. iii AGRADECIMIENTOS A la Dra María Miranda Flores, por su constante apoyo en la gestión para la realización de mis estudios de maestría. Al Dr. Felipe Ignacio Concchoy, mi asesor y docente en la maestría, de quien aprendí muchísimo sobre investigación, gracias por enseñarnos con humildad y paciencia. A Priscila Gutiérrez, mi gran amiga, sin tu ayuda no sería posible esta investigación. A Lissette Flores, quien fue determinante para definir el tema investigado. Al profesor David Aliaga, mi estadista, una excelente persona y profesional, gracias por el apoyo constante. Al Mg. Johhny Ambulay, un excelente investigador en el área de la Nutrición, gracias por las orientaciones y apoyo.

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Cigarette Smoking, Alcohol Consumption and Overweight in Multiple Sclerosis: Disability Progression

Cited by 29 publications

References 37 publications

Protective and Risk Factors in Multiple Sclerosis

Protective and Risk Factors in Multiple Sclerosis

Predictors of Multiple Sclerosis Severity Score in Patients with Multiple Sclerosis

Estilo de vida saludable de las madres y microbiota intestinal en neonatos prematuros de un hospital de Lima en el 2017

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