2017
DOI: 10.1038/srep39945
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Abstract: Endothelial dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants derived from cigarette smoke is known to promote coronary atherosclerosis and increase the likelihood of myocardial infarctions and strokes. Conversely, laminar flow protects against endothelial dysfunction, at least in the initial phases of atherogenesis. We studied the effects of TNFα and cigarette smoke extract on human coronary artery endothelial cells under oscillatory, normal laminar and elevated … Show more

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Cited by 34 publications
(36 citation statements)
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“…[21] who observed 96% of thrombi either proximal to, or within the minimal lumen area (point of maximum stenosis), where the flow is predicted to be elevated and laminar, in 209 cases of OCT-defined erosion, a result that is supported by another independent study [47]. If causal, this association could result from the profound influence of the haemodynamic environment in regulating endothelial function and dysfunction [25][26][27][28][29], with the response to elevated flow eliciting a distinct pattern of gene expression [17,37]. We and others have previously demonstrated that different flow patterns (and in our case pathologically-relevant elevated flow) changes endothelial behaviour and in particular the response to noxious stimuli that induce endothelial dysfunction [17,37,38].…”
Section: Discussionmentioning
confidence: 80%
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“…[21] who observed 96% of thrombi either proximal to, or within the minimal lumen area (point of maximum stenosis), where the flow is predicted to be elevated and laminar, in 209 cases of OCT-defined erosion, a result that is supported by another independent study [47]. If causal, this association could result from the profound influence of the haemodynamic environment in regulating endothelial function and dysfunction [25][26][27][28][29], with the response to elevated flow eliciting a distinct pattern of gene expression [17,37]. We and others have previously demonstrated that different flow patterns (and in our case pathologically-relevant elevated flow) changes endothelial behaviour and in particular the response to noxious stimuli that induce endothelial dysfunction [17,37,38].…”
Section: Discussionmentioning
confidence: 80%
“…If causal, this association could result from the profound influence of the haemodynamic environment in regulating endothelial function and dysfunction [25][26][27][28][29], with the response to elevated flow eliciting a distinct pattern of gene expression [17,37]. We and others have previously demonstrated that different flow patterns (and in our case pathologically-relevant elevated flow) changes endothelial behaviour and in particular the response to noxious stimuli that induce endothelial dysfunction [17,37,38]. In addition, the CFD simulations and subsequent statistical post-processing indicted that several OCT-defined erosions occurred in regions with modest or no stenosis, where the predominant flow feature was oscillatory shear stress (defined through OSI) [48,49].…”
Section: Discussionmentioning
confidence: 99%
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