2016
DOI: 10.1016/j.drugalcdep.2016.04.020
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Abstract: HighlightsHuman coronary artery endothelial cells show a biological response to cigarette smoke.This response was not seen following exposure to e-cigarette aerosol.Using e-cigarettes instead of cigarettes may reduce immediate cardiovascular harms.

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Cited by 51 publications
(42 citation statements)
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“…The transcription factor, Nrf2, is central to the antioxidant response in endothelial cells15303132, having been shown to increase the expression of a group of genes that includes heme oxygenase 1 (HMOX1)23. Administration of cigarette smoke extract (CSE) significantly increased HMOX1 expression to a similar extent at mRNA and protein levels in all the shear environments we tested (Fig.…”
Section: Resultsmentioning
confidence: 82%
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“…The transcription factor, Nrf2, is central to the antioxidant response in endothelial cells15303132, having been shown to increase the expression of a group of genes that includes heme oxygenase 1 (HMOX1)23. Administration of cigarette smoke extract (CSE) significantly increased HMOX1 expression to a similar extent at mRNA and protein levels in all the shear environments we tested (Fig.…”
Section: Resultsmentioning
confidence: 82%
“…3A,B). CSE also increased the expression of the other antioxidant response genes (which are validated Nrf2 targets2333) in HCAECs and in most cases the effects were amplified at the higher shear rates. By contrast, TNFα alone had no effect on any Nrf2 target gene studied at any shear rate (Fig.…”
Section: Resultsmentioning
confidence: 94%
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“…The toxicological assessment of e-cigarettes has so far reported fewer biological responses on cellular functions compared to conventional cigarettes 6,12,[25][26][27] , however, approaches for dose and matrices have been inconsistent. Yu and colleagues compared e-cigarette aerosol extracts with cigarette smoke extracts generated in media applied to both primary and immortalized epithelial cells.…”
Section: Discussionmentioning
confidence: 99%
“…From the 22 studies cited in Leigh et al 2016;Teasdale et al 2016). For instance, Misra et al (2014) found no cytotoxicity or mutagenicity of EC aerosols, but found high cytotoxicity and mutagenicity of CC smoke in human lung epithelial cells (A549).…”
Section: Cellular Level Effectsmentioning
confidence: 99%