Ciclosporin vs. clobetasol in the topical management of atrophic and erosive oral lichen planus: a double-blind, randomized controlled trial

Abstract

Clobetasol is more effective than ciclosporin in inducing clinical improvement, but the two drugs have comparable effects on symptoms. Conversely, clobetasol gives less stable results than ciclosporin when therapy ends and has shown a higher incidence of side-effects. The daily cost of ciclosporin is more than five times higher than clobetasol.

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

“…For instance, clobetasol propionate appeared to be one of the most effective topical steroids, as in an adhesive base led to complete remission in 56-75% of patients [17][18][19]. Unfortunately, some patients are refractory to topical corticosteroids.…”

Medical Management of Oral Lichen Planus: A Systematic Review

“…[18] all the participants received a systemic steroid, and in another study [28] the experimental intervention was compared with intralesional steroid. Of the 29 trials using steroid as an active intervention, clobetasol was used in nine trials [4,7,10,11,19,22,23,27,35], triamcinolone in ten trials [4,5,[13][14][15][16]20,28,31,36], flucinolone in two trials [6,8], dexamethasone in two trials [29,34], prednisolone in one trial [18], fluticasone in one trial [9] & betamethasone in two trials [9,20]. Systemic prednisolone was used in one trial [18].…”

A Clinical and Histopathological Study of Lichen Planus

“…[9] In fact, according to a meta-analysis of 5,242 patients even those who did not receive retinoids might still have dyslipidaemia.…”