Cicatricial pemphigoid. Immunofluorescence investigations

Holubar, K.

doi:10.1001/archderm.108.1.50

Cited by 16 publications

(9 citation statements)

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“…A recent report by Holubar, Honigsman & Woolf (1973) of IgA in addition to IgG in a continuous pattern in two of five patients with cicatricial pemphigoid (CP) is of interest. A study by Bean & Michel (1973) of CP, however, showed only IgG to be present in five of their six patients, and this was in involved skin and mucous membrane, and it was present in only one of the six patients' uninvolved skin.…”

Section: Discussionmentioning

confidence: 99%

“…A study by Bean & Michel (1973) of CP, however, showed only IgG to be present in five of their six patients, and this was in involved skin and mucous membrane, and it was present in only one of the six patients' uninvolved skin. In the study of Holubar et al (1973) the biopsies were from involved or previously involved skin. It is reasonable that in diseases affecting the mucous membrane, as in CP, IgA should be present as part of the pathology, for IgA is the main immunoglobulin involved in the immune response of mucosal surfaces, including the buccal cavity and the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

“…Electron microscopic studies, however, may well be able to differentiate between the two conditions by localizing the site of immunoglobulin deposition, i.e., whether it is below the basement membrane in DH, or on it as in CP. It is just possible that the two patients that Holubar et al (1973) described with IgA and IgG in the skin had DH in addition to, or instead of CP, but no studies relating to the small intestine or response to dapsone were given in their report. We ourselves have one patient who has both CP and DH, indicating that the two diseases can occur together.…”

Section: Discussionmentioning

confidence: 99%

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Immunoglobulins in the skin in dermatitis herpetiformis and their relevance in diagnosis

1975

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Eighty skin biopsies from fifty patients with dermatitis herpetiformis (DH) have been examined for immunoglobulin deposits by direct immunofluorescence. IgA was found in all fifty patients. However, in two patients no IgA was detected in their first biopsy, and it is stressed that if the clinical suspicion of DH is high and no IgA is found in a single biopsy, then the biopsy should be repeated. There are two distinct patterns of immunoglobulin deposition in DH. The most common form of deposition is seen in the dermal papillae, termed the 'papillary' pattern. This pattern was the only one present in sixty-seven of the seventy-eight biopsies. A less common pattern is that of a 'continuous' line along the dermo-epidermal junction. This was the only pattern of immunoglobulin deposition in nine of the seventy-eight biopsies. In two biopsies both the papillary and continuous patterns were present. IgA was found in all seventy-eight of the positive biopsies and was the only immunoglobulin detected in sixty-seven biopsies. In addition to IgA, IgM was present in seven biopsies, and IgG in two biopsies. In one biopsy IgM and IgG were present with the IgA. The detection of IgA in the uninvolved skin in patients with DH is a simple test to perform, and at the present time is the most reliable way of establishing the diagnosis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Immunoglobulins in the skin in dermatitis herpetiformis and their relevance in diagnosis

1975

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“…Direct immunofluorescence studies show IgG and C3 in the basement membrane zone (Bean, 1975). Indirect immunofluorescence is usually negative, although a few reports have described a circulating antibody (Bean et al, 1972;Bean & Michael, 1973;Holubar, Honigsmann & Wolff, 1973;Griflith et al, 1974;Tagami & Imamura, 1974).…”

Section: Benign Mucous Membrane Pemphigoid (Cicatricial Pemphigoid)mentioning

confidence: 99%

The chronic acquired bullous diseases of childhood

Marsden¹,

Skeete²,

Black³

1979

Clin Exp Dermatol

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Due to their rarity, the chrotiic acquired bullous diseases of childhood have not yet beeti studied in detail. Constant changes in terminology and classification have so far achieved little apart from confusing clinicians. We have attempted, therefore, to interpret the literature, to define the diseases in question and have included some case reports of patients seen recently at St John's Hospital for Diseases of the Skin. The pemphigus groupWhen pemphigus occurs in children, the disease is chtiically, histologically and immunologically similar to that in adults. Beutner & Chorzelski (1976) reviewed 234 cases of pemphigus and found that the disease began before the age of 10 in four cases and between 11 and 20 years in nine. Eleven of these cases were female, an incidence 5-5 times higher than in other age groups, where the sexes are equally affected. This female preponderance in children with pemphigus has been noted elsewhere (Jordon et al, 1976). It is of interest that a much larger proportion of affected children had pemphigus foliaceus or erythematosus (sis out of thirteen cases) compared with adults (twenty-seven out of 221 cases).

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“…However, in contrast to BP, IgA has been found nearly as frequently as IgG [10,13,22] and also IgM has been demonstrated in a relatively high number of the cases [22], The uninvolved skin was only positive in a low number of cases [2,24]. The incidence of circulating IgG and IgA anti-BM antibodies is low in CP, but their occurrence had been reported [5,6,26],…”

Section: Introductionmentioning

confidence: 99%

Localized Chronic Pemphigoid

Nieboer¹,

Roeleveld²,

Kalsbeek³

1978

Dermatology

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A case of a chronic remittant blistering eruption on the left temple in a 62-year-old woman is described. Only after repeated biopsies did direct immunofluorescence (DIF) studies reveal a linear staining of the epidermal basement membrane with anti-IgG, C_1q, C₄, C₃ and C₅. In addition, heavy deposits of fibrin were observed. The importance of repeated DIF examination in initially negative cases has been stressed. Localized chronic pemphigoid should be considered as a distinct subform of the pemphigoid syndrome.

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Cicatricial pemphigoid. Immunofluorescence investigations

Cited by 16 publications

References 0 publications

Immunoglobulins in the skin in dermatitis herpetiformis and their relevance in diagnosis

Immunoglobulins in the skin in dermatitis herpetiformis and their relevance in diagnosis

The chronic acquired bullous diseases of childhood

Localized Chronic Pemphigoid

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