Cicatricial Pemphigoid and Skin Grafts

Sneddon, I. B.

doi:10.1001/archderm.1962.01590080096013

Arch Dermatol

1962

DOI: 10.1001/archderm.1962.01590080096013

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Cicatricial Pemphigoid and Skin Grafts

I. B. Sneddon¹

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1976

2002

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Cited by 8 publications

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References 6 publications

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“…The response to treatment in general was poor. Two reports have been published describing the modestly successful results of skin grafting in the treatment of extensive cutaneous ulceration that is rarely associated with cicatricial pemphigoid (Slepyan, Burks & Fox, 1961;Sneddon, 1962). O±er isolated cases of localized pemphigoid have been reported (Jonquieres, 1965;Bourlond, Philippart & Hoet, 1970;Stewart et al, 1971), but in only one case, that reported by Trepani<:r (1970), have immunofluorescent studies been performed.…”

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Localized pemphigoid

1976

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Of 144 patients with bullous or cicatricial pemphigoid, nine with localized pemphigoid were seen at the Mayo Clinic between 1968 and 1975. In two patients the disease had become generalized before presentation, and in one it had evolved into bullous pemphigoid, the only case with positive indirect immunofluorescence. One additional patient showed mucosal lesions. Direct immunofluorescence was performed in five patients and showed linear deposition of C3 and fibrin but not immunoglobulins in three; in two patients immunofluorescence was negative. Localized pemphigoid can be divided into two types: that with scarring plaque-like lesions usually occurring on the head and neck predominantly in males, and that with localized bullous lesions usually occurring on the lower part of the legs of females.

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Localized pemphigoid

1976

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“…Common clinical features include oral mucosal erosions, desquamative gingivitis, and cicatrizing conjunctivitis. Other mucous membranes such as the esophageal, laryngeal, genital, and rectal mucosa may be affected as well (1–3). Scarring of mucous membranes is common, hence the designation of this disorder as cicatricial (i.e., scarring) pemphigoid (4).…”

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Cicatricial pemphigoid: immunopathogenesis and treatment

Lazarova

Yancey

2002

Dermatol Ther

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Cicatricial pemphigoid (CP) is a chronic, autoimmune, subepidermal blistering disease of mucous membranes and skin that has a tendency to scar and result in tissue destruction. Recent studies demonstrate that CP is a heterogeneous disease in which patients can resemble each other clinically, histologically, and immunopathologically, but have autoantibodies that target different autoantigens in the epidermal basement membrane. Accordingly CP is now considered to be a disease phenotype rather than a single nosologic entity. CP can be associated with substantial morbidity, and in rare instances, mortality. Currently the management of patients with CP is grounded in clinical experience rather than the results of large randomized trials. This article discusses recent advances in the understanding of this disorder's pathophysiology and treatment.

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Cicatricial Pemphigoid and Skin Grafts

Cited by 8 publications

References 6 publications

Localized pemphigoid

Localized pemphigoid

Cicatricial pemphigoid: immunopathogenesis and treatment

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