Cicatricial Pemphigoid

Localized Chronic Pemphigoid

“…The presence ol basement membrane zone immunoglobulin and complement in both bullous pempbigoid and benign mueosal pemphigoid (Bean et al 1972) and its absence in two t-eported cases cf localized chronic pemphigoid (Trepanier 1970, Graham & Mac-Vicar 1972 led Graham and MacVicar (1972) to speculate that localized chronic pemphigoid was a distinct bli.stering disease. However, the imiiumofluorescent firnlirigs in our case, and those mentioned by Bean (1975) suggest that localized chronic pemphigoid, like benign mueosal pemphigoid, may be at one end of a spectrum ol' diseases with birlknrs pemphigoid at the other extieme (Bean et al 1972).…”

“…In a recent article. Bean (1975) referred to unpublished work whicb demonstrated basement membr-anc zone in-imunoglobulins and con-iplement in localized chr-onic pempbigoid. We are reporling a case with positive basement membr-ane immunofluor-escenee and an unusual degtee of clefting around each of the har'r follicles.…”

The chronic acquired bullous diseases of childhood

“…Benign mucous membrane pemphigoid also predominantly affects the elderly, with bhstering and scarring of the mucous membranes and relatively localised involvement of the skin. Scarring of the conjunctivae occurs in about 75% of cases (Bean, 1975) and up to 20% of patients become blind. Direct immunofluorescence studies show IgG and C3 in the basement membrane zone (Bean, 1975).…”

“…Scarring of the conjunctivae occurs in about 75% of cases (Bean, 1975) and up to 20% of patients become blind. Direct immunofluorescence studies show IgG and C3 in the basement membrane zone (Bean, 1975). Indirect immunofluorescence is usually negative, although a few reports have described a circulating antibody (Bean et al, 1972;Bean & Michael, 1973;Holubar, Honigsmann & Wolff, 1973;Griflith et al, 1974;Tagami & Imamura, 1974).…”