2008
DOI: 10.1111/j.1529-8019.2008.00203.x
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Cicatricial alopecia: classification and histopathology

Abstract: Primary cicatricial alopecias are a diagnostically challenging group of disorders characterized by folliculocentric inflammation resulting in destruction of hair follicles and irreversible hair loss. They are classified according to a consensus-issued classification scheme based on the predominant cell type present: lymphocytic, neutrophilic, or mixed. Histopathology is a pivotal component of the diagnostic evaluation. Early diagnosis is critical since timely institution of treatment can halt progression of pe… Show more

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Cited by 77 publications
(80 citation statements)
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“…Cicatricial alopecias, a group of hair loss disorders in humans that involve the total destruction of the hair follicle (HF) with associated inflammation, are also referred to as scarring alopecias because of the replacement of the HF with connective tissue (Somani and Bergfeld, 2008). In some, such as lichen planopilaris (LPP), the sebaceous gland appears atrophic because of either inflammation targeting the gland or abnormal function.…”
Section: Introductionmentioning
confidence: 99%
“…Cicatricial alopecias, a group of hair loss disorders in humans that involve the total destruction of the hair follicle (HF) with associated inflammation, are also referred to as scarring alopecias because of the replacement of the HF with connective tissue (Somani and Bergfeld, 2008). In some, such as lichen planopilaris (LPP), the sebaceous gland appears atrophic because of either inflammation targeting the gland or abnormal function.…”
Section: Introductionmentioning
confidence: 99%
“…Subtypes are classified as lymphocytic (lichen planopilaris [LPP], frontal fibrosing alopecia, chronic cutaneous lupus erythematosus, pseudopelade [Brocq], follicular degeneration syndrome [FDS], alopecia mucinosa, and keratosis follicularis spinulosa decalvans), neutrophilic (folliculitis decalvans [FD], tufted folliculitis, and dissecting cellulitis), and mixed (folliculitis acne keloidalis, folliculitis acne necrotica, and erosive pustular dermatosis). 2,3 Understanding of the origin and pathogenesis of primary SA remains an evolving process. One theory suggests that these disorders arise from sebaceous gland dysfunction.…”
mentioning
confidence: 99%
“…21 Scarring results from the destruction and subsequent fibrosis of hair follicles, and these conditions are often difficult to diagnose and treat. 52,53 Scalp examination should focus on the entire scalp to identify follicular signs (erythema, hyperkeratosis, atrophy, and changes in pigment), 24 along with the pattern of alopecia.…”
Section: Scarring Alopeciamentioning
confidence: 99%