Chronotherapy with defective circadian clock?

Zhang, Yuqing; Lévi, Francis; Chang, Yunhua

doi:10.18632/aging.101430

Cited by 3 publications

(5 citation statements)

References 7 publications

(13 reference statements)

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“…Accordingly, chronotherapy is the method of administering therapy at specific points in the circadian rhythm in the hopes of improving efficacy and tolerance to drug therapy ( Fig. 5 ) ( 265 ). Typical examples of human and animal studies are listed in Table 1 .…”

Section: Approaches Related To Environmental Risk Factors and “Chrono...mentioning

confidence: 99%

Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution

Daiber

Frenis

Wolf

et al. 2022

Antioxidants & Redox Signaling

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Significance: Risk factors in the environment such as air pollution and traffic noise contribute to the development of chronic noncommunicable diseases. Recent Advances: Epidemiological data suggest that air pollution and traffic noise are associated with a higher risk for cardiovascular, metabolic, and mental disease, including hypertension, heart failure, myocardial infarction, diabetes, arrhythmia, stroke, neurodegeneration, depression, and anxiety disorders, mainly by activation of stress hormone signaling, inflammation, and oxidative stress. Critical Issues: We here provide an in-depth review on the impact of the environmental risk factors air pollution and traffic noise exposure (components of the external exposome) on cardiovascular health, with special emphasis on the role of environmentally triggered oxidative stress and dysregulation of the circadian clock. Also, a general introduction on the contribution of circadian rhythms to cardiovascular health and disease as well as a detailed mechanistic discussion of redox regulatory pathways of the circadian clock system is provided. Future Directions: Finally, we discuss the potential of preventive strategies or “chrono” therapy for cardioprotection. Antioxid. Redox Signal . 37, 679–703.

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Section: Approaches Related To Environmental Risk Factors and “Chrono...mentioning

confidence: 99%

Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution

Daiber

Frenis

Wolf

et al. 2022

Antioxidants & Redox Signaling

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“…The rationale for this relies on the fact that time-dependent efficacy of treatments may vary according to three general aspects: 1) the mechanism of action, 2) the pharmacokinetics/metabolism and 3) the variable toxicity depending on circadian rhythms ( 30 ). Accordingly, it has been shown that regimens optimally timed with the circadian cycle have jointly improved patient outcomes in terms of tolerance and efficacy of chemotherapeutic treatments, both at the preclinical and clinical level ( 31 , 32 ). One of the best examples of this is the use of chronochemotherapy for gynecological and genitourinary cancers ( 33 ).…”

Section: Circadian Cycle In Cancermentioning

confidence: 99%

The Time for Chronotherapy in Radiation Oncology

Bermúdez-Guzmán¹,

Blanco-Saborío²,

Ramírez-Zamora³

et al. 2021

Front. Oncol.

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Five decades ago, Franz Halberg conceived the idea of a circadian-based therapy for cancer, given the differential tolerance to treatment derived from the intrinsic host rhythms. Nowadays, different experimental models have demonstrated that both the toxicity and efficacy of several anticancer drugs vary by more than 50% as a function of dosing time. Accordingly, it has been shown that chemotherapeutic regimens optimally timed with the circadian cycle have jointly improved patient outcomes both at the preclinical and clinical levels. Along with chemotherapy, radiation therapy is widely used for cancer treatment, but its effectiveness relies mainly on its ability to damage DNA. Notably, the DNA damage response including DNA repair, DNA damage checkpoints, and apoptosis is gated by the circadian clock. Thus, the therapeutic potential of circadian-based radiotherapy against cancer is mainly dependent upon the control that the molecular clock exerts on DNA repair enzymes across the cell cycle. Unfortunately, the time of treatment administration is not usually considered in clinical practice as it varies along the daytime working hours. Currently, only a few studies have evaluated whether the timing of radiotherapy affects the treatment outcome. Several of these studies show that it is possible to reduce the toxicity of the treatment if it is applied at a specific time range, although with some inconsistencies. In this Perspective, we review the main advances in the field of chronoradiotherapy, the possible causes of the inconsistencies observed in the studies so far and provide some recommendations for future trials.

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“…Importantly, many environmental changes impact on cardiac mitochondria especially under stress conditions, potentially rendering the cardiomyocytes less resistant towards ischaemia and reperfusion injury. with little variation in fatty acid oxidation (Young et al, 2001). Hearts were isolated either in the middle of the light phase (ZT6) or the middle of the dark phase (ZT18).…”

Section: Mitochondria and Environmental Changesmentioning

confidence: 99%

“…Using the circadian clock to our advantage when administering therapies may be beneficial for clinical outcomes (Figure 5). Chronotherapy is the study of rhythmic cycles such as circadian and seasonal cycles and administering drug therapies in optimised circadian delivery schedules to improve the efficacy and tolerance to drug therapies (Zhang, Levi, & Chang, 2018). Cancer is known to be a chronotherapeutic disorder that requires a high dose of chemotherapy to kill cancerous cells and in the process damage normal cells leading to toxic side effects that includes cardiotoxicity.…”

Section: Approaches Related To Environmental Risk Factors and “Chronomentioning

confidence: 99%

“…Genes encoding for key proteins (citrate synthase, mitochondrial thioesterase 1 and uncoupling proteins) involved in mitochondrial metabolism and function showed a diurnal variation, a finding lost under pathophysiological conditions such as pressure overload or hypoxia(Young, Razeghi, Cedars, Guthrie, & Taegtmeyer, 2001). In isolated rat hearts, contractile performance, carbohydrate oxidation and oxygen consumption were greatest in the middle of the night,…”

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confidence: 99%

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Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection

Kilgallen

Münzel

et al. 2020

Br J Pharmacol

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Risk factors in the environment such as air pollution and mental stress contribute to the development of chronic non-communicable disease. Air pollution was identified as the leading health risk factor in the physical environment, followed by water pollution, soil pollution/heavy metals/chemicals and occupational exposures, however neglecting the non-chemical environmental health risk factors (e.g. mental stress and noise). Epidemiological data suggest that environmental risk factors are associated with higher risk for cardiovascular, metabolic and mental diseases, including hypertension, heart failure, myocardial infarction, diabetes, arrhythmia, stroke, depression and anxiety disorders. We provide an overview on the impact of the external exposome comprising risk factors/exposures on cardiovascular health with a focus on dysregulation of stress hormones, mitochondrial function, redox balance and inflammation with special emphasis on the circadian clock. Finally, we assess the impact of circadian clock dysregulation on cardiovascular health and the potential of environment-specific preventive strategies or "chrono" therapy for cardioprotection.

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Chronotherapy with defective circadian clock?

Cited by 3 publications

References 7 publications

Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution

Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution

The Time for Chronotherapy in Radiation Oncology

Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection

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