Chronological SPECT studies of a patient with subacute sclerosing panencephalitis

Physiological assessment of paroxysmal dystonia secondary to subacute sclerosing panencephalitis

“…Serial interictal SPECT studies in two cases of SSPE have demonstrated hypoperfusion in the cerebellum and parieto‐occiptal regions 9, 10. The second patient was noted to have a history of involuntary movements of his right hand characterized as myoclonus but was not reported to have movements while being studied.…”

Physiological assessment of paroxysmal dystonia secondary to subacute sclerosing panencephalitis

“…Serial interictal SPECT studies in two cases of SSPE have demonstrated hypoperfusion in the cerebellum and parieto‐occiptal regions 9, 10. The second patient was noted to have a history of involuntary movements of his right hand characterized as myoclonus but was not reported to have movements while being studied.…”

Neuropeptide Y Counteracts Interferon-Alpha-Induced Anorexia

“…This short-term NPY effect could have implications for IFN-· immunotherapy. For example, in conditions where IFN-· is administered intracerebroventricularly or intrathecally [12][13][14][15][16], the NPY short-term effect could be timed to coordinate with the eating schedule of a subject receiving IFN-· therapy. This will maximize the feeding induction properties of NPY, while not influencing hunger at times where it would be inappropriate (during sleeping periods, for example).…”

“…The dose of IFN-· used in these experiments was based on an immunotherapeutic dose administered intracerebroventricularly or intrathecally for the treatment of subacute sclerosing panencephalitis [12][13][14][15][16]. A dose of 1 !…”

“…In a clinical setting, IFN-· immunotherapy into the brain involves the repeated intraventricular or intrathecal infusion of IFN-· several times a week [12][13][14][15][16]. Consequently, the IFN-·-induced anorexia could be associated with weight loss and changes in metabolic activities [22,30].…”

“…IFN-· is used in the treatment of solid tumors [4][5][6], leukemia [5], and chronic infections including hepatitis B [4,5,7], C [8][9][10][11] and subacute sclerosing panencephalitis [12][13][14][15][16].…”

Physiological assessment of paroxysmal dystonia secondary to subacute sclerosing panencephalitis

“…Serial interictal SPECT studies in two cases of SSPE have demonstrated hypoperfusion in the cerebellum and parieto‐occiptal regions 9, 10. The second patient was noted to have a history of involuntary movements of his right hand characterized as myoclonus but was not reported to have movements while being studied.…”

Neuropeptide Y Counteracts Interferon-Alpha-Induced Anorexia

“…This short-term NPY effect could have implications for IFN-· immunotherapy. For example, in conditions where IFN-· is administered intracerebroventricularly or intrathecally [12][13][14][15][16], the NPY short-term effect could be timed to coordinate with the eating schedule of a subject receiving IFN-· therapy. This will maximize the feeding induction properties of NPY, while not influencing hunger at times where it would be inappropriate (during sleeping periods, for example).…”

“…The dose of IFN-· used in these experiments was based on an immunotherapeutic dose administered intracerebroventricularly or intrathecally for the treatment of subacute sclerosing panencephalitis [12][13][14][15][16]. A dose of 1 !…”

“…In a clinical setting, IFN-· immunotherapy into the brain involves the repeated intraventricular or intrathecal infusion of IFN-· several times a week [12][13][14][15][16]. Consequently, the IFN-·-induced anorexia could be associated with weight loss and changes in metabolic activities [22,30].…”

“…IFN-· is used in the treatment of solid tumors [4][5][6], leukemia [5], and chronic infections including hepatitis B [4,5,7], C [8][9][10][11] and subacute sclerosing panencephalitis [12][13][14][15][16].…”

Physiological assessment of paroxysmal dystonia secondary to subacute sclerosing panencephalitis

“…Serial interictal SPECT studies in two cases of SSPE have demonstrated hypoperfusion in the cerebellum and parieto‐occiptal regions 9, 10. The second patient was noted to have a history of involuntary movements of his right hand characterized as myoclonus but was not reported to have movements while being studied.…”

Neuropeptide Y Counteracts Interferon-Alpha-Induced Anorexia

“…This short-term NPY effect could have implications for IFN-· immunotherapy. For example, in conditions where IFN-· is administered intracerebroventricularly or intrathecally [12][13][14][15][16], the NPY short-term effect could be timed to coordinate with the eating schedule of a subject receiving IFN-· therapy. This will maximize the feeding induction properties of NPY, while not influencing hunger at times where it would be inappropriate (during sleeping periods, for example).…”

“…The dose of IFN-· used in these experiments was based on an immunotherapeutic dose administered intracerebroventricularly or intrathecally for the treatment of subacute sclerosing panencephalitis [12][13][14][15][16]. A dose of 1 !…”

“…In a clinical setting, IFN-· immunotherapy into the brain involves the repeated intraventricular or intrathecal infusion of IFN-· several times a week [12][13][14][15][16]. Consequently, the IFN-·-induced anorexia could be associated with weight loss and changes in metabolic activities [22,30].…”

“…IFN-· is used in the treatment of solid tumors [4][5][6], leukemia [5], and chronic infections including hepatitis B [4,5,7], C [8][9][10][11] and subacute sclerosing panencephalitis [12][13][14][15][16].…”