Chronological age vs biological age: an age-related normogram for antral follicle count, FSH and anti-Mullerian hormone

Abstract

ObjectiveTo evaluate the correlation between chronological and biological age by comparing the normograms of AFC, AMH, and FSH.DesignRetrospective studySettingData were taken from patients who visited the Infertility Clinic at Dr. Cipto Mangunkusumo General Hospital Jakarta, Indonesia, between January 2008 and December 2010.Patient(s)Infertile women who visited the Infertility Clinic.Intervention(s)None.Main Outcome Measure(s)Normogram of AFC (n = 366), AMH (n = 1616) and FSH (n = 415).Result(s)The correlations among AFC, AMH, FSH, and age are statistically significant. Normograms of AFC and AMH with 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles showed a decrease in age where FSH increased. A cut-off value of AFC, AMH, and FSH for poor responders was plotted at the 50th percentile of each normogram. Serum AMH and AFC started to decline in women between 34 and 35 years old. We found a relatively lower slope increase of FSH in older patients compared to that of AFC and AMH. FSH was observed to be a later predictor of biological age than AMH and AFC.Conclusion(s)AMH predicted biological age earlier than FSH or AFC. Normograms can provide a reference guide for physicians to counsel infertile women. However, future validation with longitudinal data is still needed.

Differences between biological and chronological age‐at‐death in human skeletal remains: A change of perspective

“…Taking the opposite view, this research maintains that ‘inaccuracy’, i.e., the difference between CA and BA, is a repercussion of individual variations in longevity as well as individual differences in the onset and variations in the aging processes due to genetic, epigenetic, and environmental conditions (Bae et al, ; Belsky et al, ; Cho, Park, & Lim, ; de Rooij & Roseboom, ; Levine, ). Indeed, research in living populations found the estimated standard deviation of the difference between CA and BA varies between three and 10 years (Belsky et al, ; Hochschild, ; Klemera & Doubal, ), and because the health of individuals is highly heterogeneous, as is the rate of aging, discordances between BA and CA can take place from a young age (Belsky et al, ; Molinari, Gasser, & Largo, ; Wiweko et al, ) not just among older individuals as is often assumed.…”

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

“…However, our research did not find that these two variables acted as a single variable to significantly assess ovarian function. Serum AMH and AFC begin to decline in women between 34 and 35 years old, and AMH predicts biological age earlier than FSH or AFC do, and AFC does so earlier than FSH does [17]. By age 32, over 50% of women with subfertility had AMH levels categorized as "low fertility" (AMH ≤ 19.5 pmol/liter), a figure that increased to 75% by age 39, with a decrease in mean AMH of 1.72 pmol/liter/year [18].…”

“…Many studies [17][18][19][20][21] have discussed how AFC and AMH could be used to assess ovarian reserve.…”

Age‐specific reference ranges of serum anti‐müllerian hormone in healthy women and its application in diagnosis of polycystic ovary syndrome: a population study

“…Although there have been a number of published age-specific reference ranges for AMH assayed by manual ELISA in Chinese 23,24 as well as other populations, 14,15,[25][26][27] few are available for the automated assays. Some are available for another automated assay platform manufactured by Roche Diagnostics, 28,29 but as numerical values generated from the two automated platforms are non-equivalent, it would be necessary to establish one specifically for the Access AMH assay.…”