Chronic toxicity and oncogenicity of inhaled methyl acrylate and n-butyl acrylate in Sprague-Dawley rats

Upper airway symptoms and function in wood surface coating industry workers

“…NPEF is not the best method for detection for a swollen lining in the roof of the nose. Animal studies conducted on monofunctional acrylates (e.g., methyl acrylate, ethyl acrylate, methyl methacrylate) have indicated irritative and degenerative effects (e.g., loss of olfaction epithelium and replacement of the olfaction epithelium to respiratory epithelium) of these vapors in the nasal mucosa [Chan et al, 1988;Klimisch and Reininghaus, 1984;Miller et al, 1985;Reininghaus et al, 1991;Tansy et al, 19801. No signs of airway restriction or airway obstruction were observed using the Vitalograph. However, a hidden pulmonary obstruction cannot be excluded, since we did not perform a test for reversibility of pulmonary resistance in this study.…”

Upper airway symptoms and function in wood surface coating industry workers

“…NPEF is not the best method for detection for a swollen lining in the roof of the nose. Animal studies conducted on monofunctional acrylates (e.g., methyl acrylate, ethyl acrylate, methyl methacrylate) have indicated irritative and degenerative effects (e.g., loss of olfaction epithelium and replacement of the olfaction epithelium to respiratory epithelium) of these vapors in the nasal mucosa [Chan et al, 1988;Klimisch and Reininghaus, 1984;Miller et al, 1985;Reininghaus et al, 1991;Tansy et al, 19801. No signs of airway restriction or airway obstruction were observed using the Vitalograph. However, a hidden pulmonary obstruction cannot be excluded, since we did not perform a test for reversibility of pulmonary resistance in this study.…”

High-Affinity Nasal Extraction of Vinyl Acetate Vapor Is Carboxylesterase Dependent

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Analysis of Vinyl Acetate Metabolism in Rat and Human Nasal Tissues by anin VitroGas Uptake Technique

“…Many inhaled esters show a preferential cytotoxic effect in olfactory epithelium (Miller et al, 1984(Miller et al, , 1985Reininghaus et al, 1991;Keenan et al, 1990). Ultrastructural evaluation of the early degenerative changes in olfactory epithelium induced by dibasic esters show that the sustentacular cell, not the sensory cell, undergoes the earliest necrotic changes such as vesicular swelling of cytoplasmic organelles and nuclear swelling and dispersion of chromatin (Trela et al, 1992).…”

Upper airway symptoms and function in wood surface coating industry workers

“…NPEF is not the best method for detection for a swollen lining in the roof of the nose. Animal studies conducted on monofunctional acrylates (e.g., methyl acrylate, ethyl acrylate, methyl methacrylate) have indicated irritative and degenerative effects (e.g., loss of olfaction epithelium and replacement of the olfaction epithelium to respiratory epithelium) of these vapors in the nasal mucosa [Chan et al, 1988;Klimisch and Reininghaus, 1984;Miller et al, 1985;Reininghaus et al, 1991;Tansy et al, 19801. No signs of airway restriction or airway obstruction were observed using the Vitalograph. However, a hidden pulmonary obstruction cannot be excluded, since we did not perform a test for reversibility of pulmonary resistance in this study.…”

High-Affinity Nasal Extraction of Vinyl Acetate Vapor Is Carboxylesterase Dependent

“……”

Analysis of Vinyl Acetate Metabolism in Rat and Human Nasal Tissues by anin VitroGas Uptake Technique

“…Many inhaled esters show a preferential cytotoxic effect in olfactory epithelium (Miller et al, 1984(Miller et al, , 1985Reininghaus et al, 1991;Keenan et al, 1990). Ultrastructural evaluation of the early degenerative changes in olfactory epithelium induced by dibasic esters show that the sustentacular cell, not the sensory cell, undergoes the earliest necrotic changes such as vesicular swelling of cytoplasmic organelles and nuclear swelling and dispersion of chromatin (Trela et al, 1992).…”

Upper airway symptoms and function in wood surface coating industry workers

“…NPEF is not the best method for detection for a swollen lining in the roof of the nose. Animal studies conducted on monofunctional acrylates (e.g., methyl acrylate, ethyl acrylate, methyl methacrylate) have indicated irritative and degenerative effects (e.g., loss of olfaction epithelium and replacement of the olfaction epithelium to respiratory epithelium) of these vapors in the nasal mucosa [Chan et al, 1988;Klimisch and Reininghaus, 1984;Miller et al, 1985;Reininghaus et al, 1991;Tansy et al, 19801. No signs of airway restriction or airway obstruction were observed using the Vitalograph. However, a hidden pulmonary obstruction cannot be excluded, since we did not perform a test for reversibility of pulmonary resistance in this study.…”

High-Affinity Nasal Extraction of Vinyl Acetate Vapor Is Carboxylesterase Dependent

“……”

Analysis of Vinyl Acetate Metabolism in Rat and Human Nasal Tissues by anin VitroGas Uptake Technique

“…Many inhaled esters show a preferential cytotoxic effect in olfactory epithelium (Miller et al, 1984(Miller et al, , 1985Reininghaus et al, 1991;Keenan et al, 1990). Ultrastructural evaluation of the early degenerative changes in olfactory epithelium induced by dibasic esters show that the sustentacular cell, not the sensory cell, undergoes the earliest necrotic changes such as vesicular swelling of cytoplasmic organelles and nuclear swelling and dispersion of chromatin (Trela et al, 1992).…”