PLoS ONE volume 9, issue 5, Pe98283 2014 DOI: 10.1371/journal.pone.0098283 View full text
Silin Pang, Huali Wu, Qian Wang, Minxuan Cai, Weimin Shi, Jing Shang

Abstract: Chronic stress can affect skin function, and some skin diseases might be triggered or aggravated by stress. Stress can activate the central hypothalamic–pituitary–adrenocortical (HPA) axis, which causes glucocorticoid levels to increase. The skin has HPA axis elements that react to environmental stressors to regulate skin functions, such as melanogenesis. This study explores the mechanism whereby chronic stress affects skin pigmentation, focusing on the HPA axis, and investigates the role of glucocorticoids in…

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