2010
DOI: 10.1016/j.pain.2010.05.031
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Abstract: Chronic stressful events induce biochemical, physiological and psychological changes, resulting in stress-related neuropsychiatric disorders, such as anxiety or depression. Using repeated social defeat as a stressful event model, we show that this preclinical paradigm induces a transient increase in the expression of the genes encoding the pro-inflammatory molecules iNOS and COX-2. We provide the first demonstration that chronic stress affects spinal plasticity through a mechanism involving local neuroinflamma… Show more

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Cited by 126 publications
(100 citation statements)
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References 46 publications
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“…Cyclooxygenase-2 and nitric oxide synthase transiently increased in the spinal cord of socially defeated rats that displayed mechanical hyperalgesia. The effect was countered with the administration of aspirin (Rivat et al, 2010). These studies suggest that stress affects the nociceptive processing in the dorsal horn either directly or indirectly via the top-down modulation of pain.…”
Section: Spinal Cordmentioning
confidence: 79%
See 1 more Smart Citation
“…Cyclooxygenase-2 and nitric oxide synthase transiently increased in the spinal cord of socially defeated rats that displayed mechanical hyperalgesia. The effect was countered with the administration of aspirin (Rivat et al, 2010). These studies suggest that stress affects the nociceptive processing in the dorsal horn either directly or indirectly via the top-down modulation of pain.…”
Section: Spinal Cordmentioning
confidence: 79%
“…The RVM is hypothesized to mediate descending facilitation of pain in the forced swim-induced hyperalgesia in the formalin test, which in turn is attenuated after ibotenic acid-induced lesion of the RVM (Imbe et al, 2010). A cholecystokinin (CCK)2 receptor antagonist administered directly into the RVM also blocked the stress-induced anxiety and hyperalgesia in repeated social defeat model of SD rats (Rivat et al, 2010). But the CCK2 receptor antagonist (YM022) injected into the RVM had no effect on stressinduced thermal hyperalgesia.…”
Section: Rostral Ventromedial Medullamentioning
confidence: 99%
“…Clinical and preclinical studies have demonstrated that altered sensitivity to noxious stimuli, or increased incidence and severity of chronic pain, is associated with a large number of disorders of the central nervous system, including depression Dworkin et al, 1995;Klauenberg et al, 2008;Shi et al, 2010a;Shi et al, 2010b;Terhaar et al, 2010), anxiety disorders (Asmundson and Katz, 2009;Finn et al, 2006;Geuze et al, 2007;Ploghaus et al, 2001;Rivat et al, 2010), multiple sclerosis (Kenner et al, 2007;Olechowski et al, 2009;Solaro et al, 2003) and others. Thus, a passive-avoidance paradigm using air-puff in place of noxious foot-shock may also be preferable for assessment of aversive learning and memory in rodent models of these disorders.…”
Section: Discussionmentioning
confidence: 99%
“…ND rats were considered to be controls for social defeat due to the presence of the stress of a novel environment, but without application of a challenge. This chronic stress model induces an anxiety-like state that can be detected 5 days later on Dϩ10 (6,36,37).…”
Section: Chlordiazepoxidementioning
confidence: 99%
“…In the first part of this study, we, therefore, determined the long-term effect on respiratory rate 10 and 30 days after social defeat, a chronic emotional stress that induces an anxiety-like state (6,36,37). We also tested the involvement of the DMH and 5-HT 3 NTS receptors in this effect.…”
mentioning
confidence: 99%