Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice

Gilabert-Juan, Javier; Castillo-Gómez, Esther; Guirado, Ramón; Moltó, María Dolores; Nácher, Juan

doi:10.1007/s00429-012-0479-1

Cited by 115 publications

(126 citation statements)

References 59 publications

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“…In coincidence with the present data, a recent study from our laboratory has shown that chronic stress alters the expression of molecules related to synapses and inhibitory neurotransmission, as well as the number of GAD67 expressing cells, in the mPFC of adult mice (Gilabert-Juan et al, 2013) Animals subjected to chronic stress undergo changes in different CNS regions, including the mPFC, that are relevant to human psychiatric conditions, such as anxiety and depression (McEwen, 2000) and there is a clear link between PFC dysfunction and mood disorders such as major depression (Brody et al, 2001).…”

Section: Involvement Of the Plasticity Of Medial Prefrontal Cortex Insupporting

confidence: 90%

“…Although previous reports in this strain of mice have described changes in PSA-NCAM expression after chronic stress in the amygdala , in consonance with the present results no significant changes in the expression of this molecule were observed in the mPFC of GIN mice after this aversive experience (Gilabert-Juan et al, 2013). Notwithstanding, we have observed a trend towards an increase in many of the layers of prefrontocortical regions, which may indicate that significant changes in this parameter may have occurred previously, or could be detected with a prolonged STZ treatment.…”

Section: Involvement Of the Plasticity Of Medial Prefrontal Cortex Insupporting

confidence: 89%

“…The expression of PSA-NCAM is regulated by chronic stress in the hippocampus (Pham et al, 2003;Sandi et al, 2001), the amygdala (Cordero et al, 2005), the piriform cortex (Nacher et al, 2004) and other cerebral regions (see (Sandi, 2004), for review). Although a recent report from our laboratory has not found changes in the number of PSA-NCAM immunoreactive neurons in the mPFC after chronic stress (Gilabert-Juan et al, 2013), changes in the expression of PSA-NCAM in this region have been reported after chronic social isolation stress (Djordjevic et al, 2012a) or chronic treatment with antidepressants (Djordjevic et al, 2012b;Guirado et al, 2012;Sairanen et al, 2007;Varea et al, 2007a). Moreover, experiments depleting PSA from or altering the expression of this molecule in the mPFC have revealed profound alterations in the inhibitory circuits of this cortical region , 2008Guirado et al, 2014Guirado et al, , 2012.…”

Section: Introductionmentioning

confidence: 91%

“…In a similar way, chronic stress in experimental animals also affects GABA levels and inhibitory neurotransmission in the mPFC (Gilabert-Juan et al, 2013;Shalaby and Kamal, 2009). Interestingly, interneurons, as pyramidal neurons, in the mPFC also respond with structural changes to chronic stress, increasing their dendritic arborization (Gilabert-Juan et al, 2013). These changes in interneuronal structure may be mediated by the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), which is exclusively expressed by interneurons in the mPFC of rodents (Gómez-Climent et al, 2011;Varea et al, 2005) and humans (Varea et al, 2007b).…”

Section: Introductionmentioning

confidence: 94%

“…Patients suffering from major depression and experimental animals subjected to chronic stress display alterations in inhibitory neurotransmission: GABA and GAD-67 levels as well as the density and size of certain GABAergic interneurons are significantly reduced in the PFC of depressed subjects (Hasler et al, 2007;Karolewicz et al, 2010;Krystal et al, 2002;Oh et al, 2012;Rajkowska et al, 2007). In a similar way, chronic stress in experimental animals also affects GABA levels and inhibitory neurotransmission in the mPFC (Gilabert-Juan et al, 2013;Shalaby and Kamal, 2009). Interestingly, interneurons, as pyramidal neurons, in the mPFC also respond with structural changes to chronic stress, increasing their dendritic arborization (Gilabert-Juan et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

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Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons

Castillo-Gómez

Coviello

Pérez-Rando

et al. 2015

Brain Research Bulletin

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Section: Involvement Of the Plasticity Of Medial Prefrontal Cortex Insupporting

confidence: 90%

Section: Involvement Of the Plasticity Of Medial Prefrontal Cortex Insupporting

confidence: 89%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons

Castillo-Gómez

Coviello

Pérez-Rando

et al. 2015

Brain Research Bulletin

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Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine

Leng,

Zhuang,

Lin

et al. 2023

Advanced Science

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Dysfunction of parvalbumin (PV) neurons is closely involved in depression, however, the detailed mechanism remains unclear. Based on the previous finding that multiple endocrine neoplasia type 1 (Protein: Menin; Gene: Men1) mutation (G503D) is associated with a higher risk of depression, a Menin‐G503D mouse model is generated that exhibits heritable depressive‐like phenotypes and increases PV expression in brain. This study generates and screens a serial of neuronal specific Men1 deletion mice, and found that PV interneuron Men1 deletion mice (PcKO) exhibit increased cortical PV levels and depressive‐like behaviors. Restoration of Menin, knockdown PV expression or inhibition of PV neuronal activity in PV neurons all can ameliorate the depressive‐like behaviors of PcKO mice. This study next found that ketamine stabilizes Menin by inhibiting protein kinase A (PKA) activity, which mediates the anti‐depressant function of ketamine. These results demonstrate a critical role for Menin in depression, and prove that Menin is key to the antidepressant function of ketamine.

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Reduced interneuronal dendritic arborization in CA1 but not in CA3 region of mice subjected to chronic mild stress

et al. 2016

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IntroductionChronic stress induces dendritic atrophy and decreases spine density in excitatory hippocampal neurons, although there is also ample evidence indicating that the GABAergic system is altered in the hippocampus after this aversive experience. Chronic stress causes dendritic remodeling both in excitatory neurons and interneurons in the medial prefrontal cortex and the amygdala.MethodsIn order to know whether it also has an impact on the structure and neurotransmission of hippocampal interneurons, we have analyzed the dendritic arborization, spine density, and the expression of markers of inhibitory synapses and plasticity in the hippocampus of mice submitted to 21 days of mild restrain stress. The analyses were performed in GIN mice, a strain that displays EGFP‐labeled interneurons.ResultsWe observed a significant decrease in the dendritic arborization of interneurons in the CA1 region, which did not occur in those in CA3. We found neither changes in dendritic spine density in these regions nor alterations in the number of EGFP‐positive interneurons. Nevertheless, the expression of glutamic acid decarboxylase 67 was reduced in different layers of CA1 and CA3 regions of the hippocampus. No significant changes were found in the expression of the polysialylated form of the neural cell adhesion molecule (PSA‐NCAM) or synaptophysin.ConclusionsChronic stress reduces the interneuronal dendritic arborization in CA1 region of the hippocampus but not in CA3.

show abstract

Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice

Cited by 115 publications

References 59 publications

Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons

Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons

Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine

Reduced interneuronal dendritic arborization in CA1 but not in CA3 region of mice subjected to chronic mild stress

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