Chronic silicone embolism syndrome due to <scp>PIP</scp> breast implant leakage – a new entity?

Gopinath, Preethi Parvathi; Ali, Ahsan; Tornout, Filip Van; Kamath, Ajay; Crawford, Michael; Nicholson, Andrew G.

doi:10.1111/his.12518

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…Therefore, CPSE also carries the potential of causing grave complications like acute respiratory failure and death. Fortunately, the reported cases of CPSE have presented as a chronic form of lung disease mimicking interstitial lung disease (ILD) [ 9 – 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Acute pulmonary silicone embolism (APSE) from cosmetic silicone injections is well known to cause lung disease [ 3 – 8 ]. Recently, cases of chronic pulmonary silicone embolism (CPSE) related to silicone and saline breast implants causing dyspnea and pulmonary infiltrates have been reported [ 9 – 13 ] ( Table 1 ). CPSE is embolization of silicone to the lungs in women with breast implantation but with no history of subcutaneous silicone injection.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Pulmonary Silicone Embolism from Breast Augmentation Is Not a Common Finding in Explanted Lungs

et al. 2018

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Objective Acute pulmonary silicone embolism (APSE) related to subcutaneous silicone injections is a well-known entity. Recently, a few cases of pathologically confirmed chronic pulmonary silicone embolism (CPSE) from breast implants have been reported. The prevalence of CPSE in women with breast augmentation is unknown. This study was done to determine the prevalence of CPSE in female lung transplant recipients with a history of breast augmentation and to determine whether breast augmentation plays a role in chronic lung diseases requiring lung transplantation. Methods A retrospective chart review was performed to identify female lung transplant recipients with a history of breast augmentation prior to or at the time of lung transplantation. Ten patients meeting these criteria were identified. The pathologic features of the explanted lungs of these patients were reexamined for CPSE by a board-certified pathologist with expertise in lung transplantation and pulmonary embolism. Results Of 1518 lung transplant recipients at Cleveland Clinic, 578 were females. Of 578 females, 10 (1.73%) had history of breast augmentation. A total of 84 H&E-stained slides from the explanted lungs from 10 cases were examined. No pathologic evidence of chronic silicone embolism was seen in any of the 10 cases. Conclusions CPSE is not associated with pulmonary disease leading to lung transplantation. Breast augmentation is not a significant contributor to pulmonary disease requiring lung transplantation. Further studies are required to ascertain the prevalence of CPSE in the general breast augmentation populace and to define the relationship between breast augmentation and pulmonary disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Pulmonary Silicone Embolism from Breast Augmentation Is Not a Common Finding in Explanted Lungs

et al. 2018

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“…Since 1993, in the current fifth generation, a new high‐strength highly cohesive silicone gel has been used, which at least reduces diffusion through the shell. Direct contact of the gel with the body, in the case of a ruptured shell, is believed to potentially have only few consequences on health because the gel does not flow and keeps its shape, but the discussion remains controversial …”

Section: Introductionmentioning

confidence: 99%

Compressive and cyclic loading of silicone breast implants and their effect on shape resilience and reliability of the shell material

Schubert¹,

Hanstein²,

Daenicke³

et al. 2018

Polymer International

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The mechanical behavior of gel-filled silicone breast implants has been examined as well as the mechanical properties of the implant shell itself. For the first time the implants were tested under compression in two different ways. Subsequently the implant shell material was analyzed by tensile test on dumbbell-shaped specimens. The results are presented in contour plots which provide a detailed view of the measured values of the samples. Finally a statistical failure analysis was carried out by means of a Weibull fit to provide further data on the mechanical behavior.

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“…The rarity of documented silicone migration from intact saline breast implants, especially in patients with breast implant illness, underscores the need for more research into the health implications of leaked silicone particles from breast implants. from ruptured saline PIP implants, which contained industrial-grade 7,8 This case report challenges the prevailing assumption that saline implants resist silicone migration and presents evidence of silicone migration to axillary lymph nodes from intact saline implants.…”

Section: Cosmetic Case Reportmentioning

confidence: 60%

Silicone Migration from Intact Saline Breast Implants

Azahaf,

Spit,

de Blok

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Summary: Breast augmentation is a widely performed surgical procedure worldwide, predominantly using silicone gel-filled implants. Concerns have primarily revolved around ruptures and the potential health risks associated with leaked silicone from silicone gel-filled implants. Cases of silicone migration from the shell of saline breast implants remain scarce. This case report introduces a unique case of a 66-year-old patient with silicone migration from intact saline breast implants. The patient presented with a range of symptoms consistent with breast implant illness. Radiological findings suggested the presence of silicone in the axillary lymph nodes, despite the integrity of the implants, thereby confirming silicone migration. Histopathological evaluation revealed a foreign body reaction and the presence of silicone in the axillary lymph nodes. Given the saline filling, the source is likely the polydimethylsiloxane shell. The rarity of documented silicone migration from intact saline breast implants, especially in patients with breast implant illness, underscores the need for more research into the health implications of leaked silicone particles from breast implants.

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Chronic silicone embolism syndrome due to PIP breast implant leakage – a new entity?

Cited by 13 publications

References 4 publications

Chronic Pulmonary Silicone Embolism from Breast Augmentation Is Not a Common Finding in Explanted Lungs

Chronic Pulmonary Silicone Embolism from Breast Augmentation Is Not a Common Finding in Explanted Lungs

Compressive and cyclic loading of silicone breast implants and their effect on shape resilience and reliability of the shell material

Silicone Migration from Intact Saline Breast Implants

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