Chronic Rhinosinusitis: Epidemiology and Burden of Disease

DeConde, Adam S.; Soler, Zachary M.

doi:10.2500/ajra.2016.30.4297

Cited by 275 publications

(260 citation statements)

References 54 publications

Supporting

Mentioning

233

Contrasting

Unclassified

Order By: Relevance

“…In clinical use for asthma or other chronic diseases, the concept of control is often applied to the most significant disease manifestations, which can be identified as those that have the greatest impact on QOL. It is well described that CRS is associated with a significant general health‐related QOL detriment that is comparable to the QOL detriment caused by severe asthma . Studies that have sought to dissect the major contributors that are associated with decreased general health‐related QOL in CRS have found that chronic sinonasal symptomatology has the greatest impact on general health‐related QOL .…”

Section: Discussionmentioning

confidence: 99%

Patient‐reported control of chronic rhinosinusitis symptoms is positively associated with general health‐related quality of life

Gray

Hoehle

Phillips

et al. 2017

Clinical Otolaryngology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Patient‐reported control of chronic rhinosinusitis symptoms is positively associated with general health‐related quality of life

Gray

Hoehle

Phillips

et al. 2017

Clinical Otolaryngology

View full text Add to dashboard Cite

show abstract

“…CRS is commonly classified by the presence or absence of nasal polyps on endoscopy or imaging as recommended by recent AAO-HNS guidelines [1]. CRS is widespread with a reported prevalence of 4.5–12% in the general population, and the subset of patients with nasal polyposis observed in population-based studies ranges from 0.5–4.3% with the higher prevalence observed in Western countries, male patients, the elderly, and asthmatics [2] [3]. …”

Section: Introductionmentioning

confidence: 99%

The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis

Vickery

Ramakrishnan²,

Suh

2019

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Purpose of Review Staphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence of S. aureus is associated with atopic disease including allergic rhinitis and atopic dermatitis and is associated with poor outcomes. Recent Findings Several different strains of S. aureus generate different toxins and gene products that can account for organism pathogenicity. S. aureus bacteria and its antigens shape the bacterial and fungal microbiome and the mucosal niche which generates host responses that can account for inflammation. The multiple disease phenotypes and molecular endotypes seen in CRSwNP can be characterized by T-helper cell environment within the inflammatory milieu, the presence of epithelial barrier dysfunction, aberrant eicosanoid metabolism, poor wound healing, and dysfunctional host-bacteria interactions which lead to recalcitrant disease and worse surgical outcomes. Summary Understanding the pathomechanisms that S. aureus utilizes to promote nasal polyp formation, prolonged tissue inflammation, and bacterial dysbiosis are essential in our efforts to identify new therapeutic approaches to resolve this chronic inflammatory process.

show abstract

“…Chronic rhinosinusitis (CRS) is one of the most common causes of olfactory dysfunction in the general population, impacting 5% to 15% of adults worldwide . Impaired olfaction is one of the cardinal symptoms of CRS and can be found in 30% to 78.2% of patients, varying somewhat by age, gender, and presence of polyps .…”

mentioning

confidence: 99%

Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis

Soler

Yoo

Schlosser

et al. 2019

Int Forum Allergy Rhinol

Self Cite

View full text Add to dashboard Cite

Background Chronic rhinosinusitis (CRS) is one of the most common causes of olfactory loss, but the pathophysiology underlying olfactory dysfunction in CRS has not been fully elucidated. Previous studies found correlations between olfactory cleft (OC) inflammatory cytokines/chemokines and olfaction in CRS. The purpose of this study was to evaluate the relationship between OC mucus inflammatory proteins and olfaction in a multi‐institutional cohort. Methods Adults with CRS were prospectively recruited. Demographics, comorbidities, olfactory assessment (Sniffin’ Sticks), computed tomography (CT), and OC mucus for protein analysis were collected. Statistical analysis was performed to determine associations between olfactory function, OC mucus protein concentrations, and CT opacification. Results Sixty‐two patients were enrolled in the study, with an average age of 48.2 (standard deviation, 16.2) years, and 56.5% were female and 59.7% were classified as CRS with nasal polyps (CRSwNP). Ten of 26 OC mucus proteins were significantly correlated with threshold, discrimination, and identification (TDI) scores and OC opacification. Subgroup analysis by polyp status revealed that, within the CRSwNP group, C‐C motif ligand 2 (CCL2), interleukin‐5 (IL‐5), IL‐6, IL‐13, IL‐10, IL‐9, tumor necrosis factor‐α (TNF‐α), CCL5, and CCL11 were significantly correlated with olfaction. For CRS without nasal polyps (CRSsNP), only C‐X‐C ligand 5 (CXCL5) showed a correlation. In CRSwNP, IL‐6, IL‐10, vascular endothelial growth factor‐A, and immunoglobulin E (IgE) correlated with OC opacification, whereas, in CRSsNP, only CXCL5 showed a correlation. OC mucus proteins and Lund‐Mackay score correlated only in the CRSsNP group (CXCL5, IL‐5, IL‐13, IgE). Conclusion Several OC mucus proteins have been found to correlate with olfactory function and OC opacification. The profile of OC mucus proteins differs between CRSsNP and CRSwNP subgroups, suggesting different mechanisms between groups, but further study is required.

show abstract

Chronic Rhinosinusitis: Epidemiology and Burden of Disease

Cited by 275 publications

References 54 publications

Patient‐reported control of chronic rhinosinusitis symptoms is positively associated with general health‐related quality of life

Patient‐reported control of chronic rhinosinusitis symptoms is positively associated with general health‐related quality of life

The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis

Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis

Contact Info

Product

Resources

About