Chronic resveratrol treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with mononeuropathy: Involvement of serotonergic system

Zhao, Xin; Chao, Yu–Faye; Wang, Chuang; Zhang, Junfang; Zhou, Wenhua; Cui, Wugeng; Ye, Feng; Xu, Ying

doi:10.1016/j.neuropharm.2014.04.021

Cited by 40 publications

(23 citation statements)

References 55 publications

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“…This is interesting and worthy of further investigations. In light of the present results and those obtained in previous reports1934, some points and implications should be taken into account in future studies. For example, is there a link between MAO-A inhibition and the predominant 5-HT 7 selectivity of fisetin and resveratrol?…”

Section: Discussionsupporting

confidence: 64%

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Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system

Zhao

Wang

Cui

et al. 2015

Sci Rep

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Fisetin, a natural flavonoid, has been shown in our previous studies to exert antidepressant-like effect. As antidepressant drugs are clinically used to treat chronic neuropathic pain, this work aimed to investigate the potential antinociceptive efficacies of fisetin against neuropathic pain and explore mechanism(s). We subjected mice to chronic constriction injury (CCI) by loosely ligating the sciatic nerves, and Hargreaves test or von Frey test was used to assess thermal hyperalgesia or mechanical allodynia, respectively. Chronic fisetin treatment (5, 15 or 45 mg/kg, p.o.) ameliorated thermal hyperalgesia (but not mechanical allodynia) in CCI mice, concomitant with escalated levels of spinal monoamines and suppressed monoamine oxidase (MAO)-A activity. The antihyperalgesic action of fisetin was abolished by chemical depletion of spinal serotonin (5-HT) but potentiated by co-treatment with 5-HTP, a precursor of 5-HT. Moreover, intraperitoneal (i.p.) or intrathecal (i.t.) co-treatment with 5-HT7 receptor antagonist SB-258719 completely abrogated fisetin's antihyperalgesia. These findings confirm that chronic fisetin treatment exerts antinociceptive effect on thermal hyperalgesia in neuropathic mice, with spinal serotonergic system (coupled with 5-HT7) being critically involved. Of special benefit, fisetin attenuated co-morbidly behavioral symptoms of depression and anxiety (evaluated in forced swim test, novelty suppressed feeding test and light-dark test) evoked by neuropathic pain.

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Section: Discussionsupporting

confidence: 64%

“…Recently, we also screened the antinociceptive bioactivities of several other naturally occurring compounds such as curcumin19 and resveratrol34 in the mouse neuropathic pain model (CCI model). Like fisetin, curcumin and resveratrol also possess antinociceptive activities when orally and chronically dosed in neuropathic mice.…”

Section: Discussionmentioning

confidence: 99%

Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system

Zhao

Wang

Cui

et al. 2015

Sci Rep

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“…5-HT 5A, 5-HT 1A, and a-2A adrenoreceptors are all known to be involved in spinal mechanisms of antinociception. 2,7,11,69,70 Blocking 5-HT 1A receptors with WAY-100635 was the only treatment that effectively reversed N 2 -AcPLZ-mediated antinociception. This suggests that increased levels of 5-HT in response to N 2 -AcPLZ acts through the 5-HT 1A receptor in the spinal cord to mediate antinociception in male mice after formalin stimulation.…”

Section: Discussionmentioning

confidence: 99%

Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice

Mifflin

Benson

Thorburn

et al. 2016

The Journal of Pain

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“…Spinal cord injuery-induced thermal hyperalgesia was inhibited by a selective serotonin reuptake inhibitor[20]. In neuropathic mice, chronic treatment with resveratrol normalized thermal hyperalgesia, an effect that was abolished with chemical depletion of serotonin but potentiated with co-administration of 5-HTP[21]. On the other hand, intraplantar administration of serotonin has been reported to produce edema and thermal hyperalgesia[22,23].…”

Section: Discussionmentioning

confidence: 99%

Serotonin enhances urinary bladder nociceptive processing via a 5-HT3 receptor mechanism

Hall

DeWitte

Ness

et al. 2015

Neuroscience Letters

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Serotonin from the descending pain modulatory pathway is critical to nociceptive processing. Its effects on pain modulation may either be inhibitory or facilitatory, depending on the type of pain and which receptors are involved. Little is known about the role of serotonergic systems in bladder nociceptive processing. These studies examined the effect of systemic administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP), on normal bladder and somatic sensation in rats. ELISA was used to quantify peripheral and central changes in serotonin and its major metabolite following 5-HTP administration, and the potential role of the 5-HT3 receptor on changes in bladder sensation elicited by 5-HTP was investigated. 5-HTP produced bladder hypersensitivity and somatic analgesia. The pro-nociceptive effect of 5-HTP was attenuated by intrathecal, but not systemic, ondansetron. Peripheral increases in serotonin, its metabolism and rate of turnover were detectable within 30 min of 5-HTP administration. Significant enhancement of serotonin metabolism was observed centrally. These findings suggest that 5-HTP increases serotonin, which may then affect descending facilitatory systems to produce bladder hypersensitivity via activation of spinal 5-HT3 receptors.

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Chronic resveratrol treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with mononeuropathy: Involvement of serotonergic system

Cited by 40 publications

References 55 publications

Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system

Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system

Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice

Serotonin enhances urinary bladder nociceptive processing via a 5-HT3 receptor mechanism

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