Chronic Relapsing Salmonella Osteomyelitis in an Immunocompetent Patient: Case Report and Literature Review

Banky, Jeremy P.; Østergaard, Lars; Spelman, Denis

doi:10.1053/jinf.2001.0925

Cited by 31 publications

(20 citation statements)

References 21 publications

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“…Although a rare possibility that might be easily missed, this should be considered in the differential diagnosis of patients residing in or who have travelled to an endemic area, who present with non-specific symptoms such as fever, abdominal pain or other gastrointestinal symptoms and backache 2. Until now, no definite consensus is in place for the treatment of Salmonella osteomyelitis and the treatment regimen usually depends on local drug sensitivity and resistance 3. We present a case report of acute vertebral osteomyelitis secondary to fluoroquinolone resistant Salmonella typhi with features of cord compression in an immunocompetent patient.…”

Section: Introductionmentioning

confidence: 98%

Bug on the back: vertebral osteomyelitis secondary to fluoroquinolone resistantSalmonella typhiin an immunocompetent patient

2015

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AlthoughSalmonellaosteomyelitis is commonly seen in immunocompromised patients, it may occasionally affect an immunocompetent host. Symptoms are usually non-specific, such as fever, abdominal or back pain; hence it should be considered in the differential diagnosis of patients with a history of travel to endemic regions. Fluoroquinolone resistance is rising and non-responsive patients should be treated with ampicillin, trimethoprim-sulfamethoxazole and ceftriaxone. We present a case of acute T8-T11 osteomyelitis with cord compression caused by a fluoroquinolone resistant strain ofSalmonella typhi.

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Section: Introductionmentioning

confidence: 98%

Bug on the back: vertebral osteomyelitis secondary to fluoroquinolone resistantSalmonella typhiin an immunocompetent patient

2015

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“…However, salmonellae are pathogens that are prone to trigger chronic and persistent infections (5,62). Since this pathogen adapts to establish a latent, nongrowing state in the intracellular environment of fibroblasts (13,33), we studied the fate of intracellular bacteria within this specific cell type.…”

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confidence: 99%

Selection of Small-Colony Variants of Salmonella enterica Serovar Typhimurium in Nonphagocytic Eucaryotic Cells

et al. 2003

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Salmonella enterica strains are enteropathogenic bacteria that survive and proliferate within vacuolar compartments of epithelial and phagocytic cells. Recently, it has been reported that fibroblast cells are capable of restricting S. enterica serovar Typhimurium intracellular growth. Here, we show that prolonged residence of bacteria in the intracellular environment of fibroblasts results in the appearance of genetically stable smallcolony variants (SCV). A total of 103 SCV isolates, obtained from four independent infections, were subjected to phenotypic analysis. The following phenotypes were observed: (i) ␦-aminolevulinic acid auxotrophy; (ii) requirement for acetate or succinate for growth in glucose minimal medium; (iii) auxotrophy for aromatic amino acids; and (iv) reduced growth rate under aerobic conditions not linked to nutrient auxotrophy. The exact mutations responsible for the SCV phenotype in three representative isolates were mapped in the lpd, hemL, and aroD genes, which code for dihydrolipoamide dehydrogenase, glutamate-1-semyaldehyde aminotransferase, and 3-dehydroquinate dehydratase, respectively. The lpd, hemL, and aroD mutants had intracellular persistence rates in fibroblasts that were 3 to 4 logs higher than that of the parental strain and decreased susceptibility to aminoglycoside antibiotics. All three of these SCV isolates were attenuated in the BALB/c murine typhoid model. Complementation with lpd ؉ , hem ؉ , and aroD ؉ genes restored the levels of intracellular persistence and antibiotic susceptibility to levels of the wild-type strain. However, virulence was not exhibited by any of the complemented strains. Altogether, our data demonstrate that similar to what it has been reported for SCV isolates of other pathogens, S. enterica SCV display enhanced intracellular persistence in eucaryotic cells and are impaired in the ability to cause overt disease. In addition, they also suggest that S. enterica SCV may be favored in vivo.

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“…These antibiotics were useful for salmonella osteomyelitis in our case. The total duration of antibiotic administration in our case was shorter than in the other 2 cases that have been documented, as Table 1 shows, but optimal duration of treatment with antibiotics for salmonella osteomyelitis is still unknown (20). This duration may be based on the resolving clinical signs and symptoms as well as the inflammatory markers returning to normal levels.…”

Section: Tonogai Et Al Salmonella Osteomyelitis Of the Distal Ramentioning

confidence: 58%

Salmonella osteomyelitis of the distal radius in a healthy young adult patient: Report of a rare case and literature review

et al. 2015

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Chronic Relapsing Salmonella Osteomyelitis in an Immunocompetent Patient: Case Report and Literature Review

Cited by 31 publications

References 21 publications

Bug on the back: vertebral osteomyelitis secondary to fluoroquinolone resistantSalmonella typhiin an immunocompetent patient

Bug on the back: vertebral osteomyelitis secondary to fluoroquinolone resistantSalmonella typhiin an immunocompetent patient

Selection of Small-Colony Variants of Salmonella enterica Serovar Typhimurium in Nonphagocytic Eucaryotic Cells

Salmonella osteomyelitis of the distal radius in a healthy young adult patient: Report of a rare case and literature review

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