Arch Pediatr Adolesc Med
 1962
DOI: 10.1001/archpedi.1962.02080020582006
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Chronic Regional Enteritis and Growth Retardation

Edna H. Sobel1
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Cited by 31 publications

(9 citation statements)
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“…In a rat model of colitis, investigators reported that the profile of plasma LH and FSH concentrations was similar to levels observed in control female rats38, suggesting that hypopituitarism may not be the cause of growth impairment in CD36,45. In contrast, others have reported diminished plasma LH and FSH levels in CD46,47 and cystic fibrosis, to a lesser extent in females than males48. Thus, the existing evidence is mixed and deserves further study to advance our understanding of the impact of CD on hypothalamic-pituitary function and statural growth.…”
Section: Discussionmentioning
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In a rat model of colitis, investigators reported that the profile of plasma LH and FSH concentrations was similar to levels observed in control female rats38, suggesting that hypopituitarism may not be the cause of growth impairment in CD36,45. In contrast, others have reported diminished plasma LH and FSH levels in CD46,47 and cystic fibrosis, to a lesser extent in females than males48. Thus, the existing evidence is mixed and deserves further study to advance our understanding of the impact of CD on hypothalamic-pituitary function and statural growth.…”
Section: Discussionmentioning
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This aspect of regional enteritis in children was reported in some detail in the paper by Sobel et al (1962). In addition, growth disturbance can be found on careful review of the young patients with the disease reported in available series of cases but is generally mentioned only casually (Crohn and Yunich, 1941).…”
Section: Growth Failurementioning
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…29 In 1986, low IGF-1 was associated with poor growth in these children 30 ; over the following decade, it was realised that the depressed concentration was a direct consequence of inflammation, 8 10 and not merely the result of poor energy intake or undernutrition. The best strategy to increase IGF-1 and therefore to improve growth is the resolution of inflammation.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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