Chronic postoperative endophthalmitis after cataract surgery secondary to vancomycin-resistant Ochrobactrum anthropi: case report and literature review

Kanjee, Raageen; Koreishi, Anjum F.; Tanna, Angelo P.; Goldstein, Debra A.

doi:10.1186/s12348-016-0094-z

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…Moreover, several of the predicted new efflux pump genes were located in opportunistic or pathogenic bacteria, e.g. Acinetobacter baumannii, Achromobacter insolitus, O. anthropi, Pandoraea pulmonicola and Burkholderia cenocepacia [66][67][68][69][70]. Among these, Acinetobacter baumannii is a notorious pathogen harbouring a wide range of mobile resistance genes against clinically relevant antibiotics, including tetracyclines [71].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes

et al. 2020

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Tetracyclines are broad-spectrum antibiotics used to prevent or treat a variety of bacterial infections. Resistance is often mediated through mobile resistance genes, which encode one of the three main mechanisms: active efflux, ribosomal target protection or enzymatic degradation. In the last few decades, a large number of new tetracycline-resistance genes have been discovered in clinical settings. These genes are hypothesized to originate from environmental and commensal bacteria, but the diversity of tetracycline-resistance determinants that have not yet been mobilized into pathogens is unknown. In this study, we aimed to characterize the potential tetracycline resistome by screening genomic and metagenomic data for novel resistance genes. By using probabilistic models, we predicted 1254 unique putative tetracycline resistance genes, representing 195 gene families (<70 % amino acid sequence identity), whereof 164 families had not been described previously. Out of 17 predicted genes selected for experimental verification, 7 induced a resistance phenotype in an Escherichia coli host. Several of the predicted genes were located on mobile genetic elements or in regions that indicated mobility, suggesting that they easily can be shared between bacteria. Furthermore, phylogenetic analysis indicated several events of horizontal gene transfer between bacterial phyla. Our results also suggested that acquired efflux pumps originate from proteobacterial species, while ribosomal protection genes have been mobilized from Firmicutes and Actinobacteria . This study significantly expands the knowledge of known and putatively novel tetracycline resistance genes, their mobility and evolutionary history. The study also provides insights into the unknown resistome and genes that may be encountered in clinical settings in the future.

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Section: Discussionmentioning

confidence: 99%

Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes

et al. 2020

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“…Disruption of the crystalline lens is a significant risk factor for endophthalmitis after penetrating trauma and may be present in up to 86–92′ of patients with post-traumatic endophthalmitis [14, 24, 25]. Furthermore, endophthalmitis involving lens capsule violation is often less responsive to intravitreal antibiotics, potentially because of the disruption of normal aqueous humor flow or sequestration of microorganisms in retained lens material [14, 24, 26, 27, 28]. Ruptured lens material may also serve as a source of nutrition for organisms introduced into the eye during trauma [14].…”

Section: Discussionmentioning

confidence: 99%

Post-Traumatic Endophthalmitis Caused by <b><i>Oerskovia turbata</i></b>

Rohowetz

Patel²,

Yannuzzi³

et al. 2019

Case Rep Ophthalmol

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Purpose: To present a previously unreported cause of bacterial endophthalmitis manifesting as delayed post-traumatic endophthalmitis ultimately responsive to total capsulectomy. Case Report: A patient presented with chronic endophthalmitis that occurred after ocular trauma with organic material and Oerskovia turbata was eventually isolated. After a prolonged treatment course, including two pars plana vitrectomies and total capsulectomy, the patient achieved 20/80 visual acuity at 1-year follow-up. Conclusion: This is the first reported patient with endophthalmitis due to O. turbata, a Gram-positive bacillus found in soil that rarely causes human infection. The infection had a delayed presentation despite early prophylactic antibiotics and was ultimately eliminated with total capsulectomy. Removal of lens and lens capsule may be necessary in the management of post-traumatic endophthalmitis unresponsive to more conservative therapy, particularly in cases involving atypical organisms and lens capsule violation.

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“…Vitrectomy is done with the administration of intravitreal drugs for better management. There is not much management required for the chronic onset of endophthalmitis, and antimicrobial therapy works on the condition [34].…”

Section: Treatmentmentioning

confidence: 99%

Endophthalmitis After Cataract Surgery: A Postoperative Complication

Wadbudhe¹,

Tidke²,

Tidake³

2022

Cureus

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Endophthalmitis is a condition of the eye caused due to complications in cataract surgery. The extent of this complication can be from minor to very serious, leading to a permanent loss of light perception. It is generally an inflammation of the fluids present in the anterior and posterior chamber of the eye, consisting of vitreous and aqueous fluid. The inflammation is due to the infection of these fluids after their exposure during or after the cataract surgery. In today's situation, patient surgery is the most frequently preferred for the correction or treatment of the cataract. There are various factors causing endophthalmitis in cataract surgery. This condition occurs mostly by the entry of infective bacteria such as staphylococcus, gramnegative organisms, and streptococcus species. As well as fungi like aspergillus and candida. Cataract surgery has many risk factors that can be divided into preoperative, intraoperative, and postoperative phases. The most common symptom of this condition is pain in the eyes and redness, which sometimes leads to purulent discharge, causing decreased vision or loss of eyesight. The increasing inflammation of the vitreous fluid is the main identification of the condition. There is a surge of inflammatory cells in the space of the vitreous fluid. The condition can be classified into two types which are exogenous and endogenous. In these types, subtypes explain the postoperative complications of the disease. It is a rare condition, and the percentage of it occurring as a postoperative complication is very low. It generally targets the old age group of people. This narrative review article explains endophthalmitis as a postoperative complication of cataract surgery and its treatment modalities. The terms endophthalmitis, postoperative, cataract surgery, complications, and vitreous humor were used for the review article in PubMed.

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Chronic postoperative endophthalmitis after cataract surgery secondary to vancomycin-resistant Ochrobactrum anthropi: case report and literature review

Cited by 11 publications

References 14 publications

Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes

Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes

Post-Traumatic Endophthalmitis Caused by <b><i>Oerskovia turbata</i></b>

Endophthalmitis After Cataract Surgery: A Postoperative Complication

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