2010
DOI: 10.1074/jbc.m109.053942
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Abstract: The recent insight that brown adipocytes and muscle cells share a common origin and in this respect are distinct from white adipocytes has spurred questions concerning the origin and molecular characteristics of the UCP1-expressing cells observed in classic white adipose tissue depots under certain physiological or pharmacological conditions. Examining precursors from the purest white adipose tissue depot (epididymal), we report here that chronic treatment with the peroxisome proliferator-activated receptor ␥ … Show more

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Cited by 1,161 publications
(1,143 citation statements)
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References 62 publications
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“…Overall, rosiglitazone – as observed before 21 – increased Pgc1a mRNA levels, and the rosiglitazone-induced Pgc1a mRNA levels were significantly higher in cells cultured in NCS than in FBS (Figure 4F). Elovl3 , which is highly induced by rosiglitazone treatment, 21 displayed substantial induction (at least 77-fold) in every serum batch analyzed (Figure 4G); no overall difference could be seen between FBS and NCS (Figure 4H). Dio2 , highly induced in BAT in the cold, 36,37 displayed little change in response to rosiglitazone (Figure 4IJ).…”
Section: Resultssupporting
confidence: 52%
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“…Overall, rosiglitazone – as observed before 21 – increased Pgc1a mRNA levels, and the rosiglitazone-induced Pgc1a mRNA levels were significantly higher in cells cultured in NCS than in FBS (Figure 4F). Elovl3 , which is highly induced by rosiglitazone treatment, 21 displayed substantial induction (at least 77-fold) in every serum batch analyzed (Figure 4G); no overall difference could be seen between FBS and NCS (Figure 4H). Dio2 , highly induced in BAT in the cold, 36,37 displayed little change in response to rosiglitazone (Figure 4IJ).…”
Section: Resultssupporting
confidence: 52%
“…Fabp4 expression has been reported to be induced upon rosiglitazone treatment in primary cultures from various adipose depots. 16,21,35 No differences between FBS and NCS were observed (Figure 4D). …”
Section: Resultsmentioning
confidence: 92%
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“…It is generally accepted that FGF21 induces this browning (Eckardt et al 2014;Poher et al 2015) which was also confirmed in UCP1-tg mice (Keipert et al 2014). Recruitable brown adipocytes within typical WAT depots [also named ''brite'', ''beige'' or ''inducible brown adipocytes'' (Harms and Seale 2013;Petrovic et al 2010;Schulz et al 2011)] were shown to be thermogenically functional (Shabalina et al 2013) and associated with improved metabolic profiles (Bartelt and Heeren 2014). On the other hand, most metabolic effects of pharmacological FGF21 administration do not require the presence of UCP1 as recently reported in two studies using UCP1 knockout mice (Samms et al 2015;Veniant et al 2015) which is in line with our findings.…”
Section: Discussionmentioning
confidence: 83%