Chronic Penicillin Urticaria from Dairy Products, Proved by Penicillinase Cures

Zimmerman, Murray C.

doi:10.1001/archderm.1959.01560130003001

Cited by 47 publications

(7 citation statements)

References 7 publications

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“…Other processes such as the manufacture of cream, butter or dried milk powder might increase the concentration of penicillin or its products. The use of penicillinase by injection or addition to food has been advocated [4] but the enzyme is itself allergenic and is no longer used.…”

Section: Discussionmentioning

confidence: 99%

“…Penicillin residues in food, partieularly milk, have long been recognized as a potential eause of urtiearia [1][2][3][4]. Boonk and Van Ketel [5], in 1982, excluded milk and milk produets from the diet in forty-two patients with positive skin tests for penieillin allergy; twenty-two had good or excellent responses whilst only two out of forty patients with negative skin tests improved on the same diet.…”

Section: Introduetionmentioning

confidence: 99%

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Penicillin in milk—its importance in urticaria

Ormerod

Reid

Main

1987

Clin Experimental Allergy

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Fifty patients with recurrent urticaria were tested by means of the RAST test for penicillin allergy. Fifteen patients had positive reaetions and of these, thirteen received provocation tests with 0-1 U/ml of penicillin in milk. Four had definite positive reactions, three doubtful reactions and six had no reaction. Although there has been improvement in the purity of milk, penicillin residues remain a potential cause of urticaria even in very low amounts and eould have contributed to the urticaria in at least 8% of our patients. Veterinary use of antibioties and food quality should be strietly regulated to prevent eontamination of our diet. IntroduetionPenicillin residues in food, partieularly milk, have long been recognized as a potential eause of urtiearia [1][2][3][4]. Boonk and Van Ketel [5], in 1982, excluded milk and milk produets from the diet in forty-two patients with positive skin tests for penieillin allergy; twenty-two had good or excellent responses whilst only two out of forty patients with negative skin tests improved on the same diet. This indirect evidence supports the role of penieillin in urtiearia but has been eriticized [6].In reeent years, legislation and financial penalties, brought about by public health and eommercial considerations, have led to a reduetion in antibiotie residues in milk, helped by the development of highly sensitive penicillin assays [7]. In the U.K., the reeommended limit for penieillin in milk has been redueed from 0-02 to 0-01 U/ml (January, 1986) but little is known ofthe prevalence of health hazards or ofthe level at whieh safety ean be assured.We undertook an investigation to try to elicit the importance of penicillin residues as a contributory factor in our patients with chronic idiopathic urticaria. A similar

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Section: Discussionmentioning

confidence: 99%

Section: Introduetionmentioning

confidence: 99%

Penicillin in milk—its importance in urticaria

Ormerod

Reid

Main

1987

Clin Experimental Allergy

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“…During the use of veterinary medicines, and especially medicated feeds, there is potential for worker exposure to antimicrobial drugs and allergic reactions have occurred as a result of such exposures (Mauranges, 1972; Neldner, 1972; Becker, 1976). Dermatitis has also occurred following occupational exposure to penicillin residues in the milk of treated cattle (Erskine, 1958; Zimmerman, 1959; Borrie & Barrett, 1961). The nitrofuran drug furazolidone is known to cause contact dermatitis (Hull & de Beer, 1977; Ancona, 1985; Altamirano & Bondani, 1989) and this has been reported after exposure to veterinary medicinal products containing the drug (de Groot & Conemans, 1990).…”

Section: Antimicrobial Drugsmentioning

confidence: 99%

“…Contact dermatitis and urticaria, either as a result of systemic sensitisation or repeated dermal exposure can also occur, for example, following the ingestion of contaminated foods or due to occupational exposure to penicillin present as residues in milk or to penicillin itself (Erskine, 1958;Vickers et al, 1958;Kautz, 1959;Zimmerman, 1959;Borrie & Barrett, 1961;Vickers, 1964;Stewart, 1967a,b;Reisman & Arbesman, 1968;Minkin & Lynch, 1969;Wicher et al, 1969;Mauranges, 1972;Olson & Sanders, 1975;Cany, 1977;Girard, 1978;Lindemayr et al, 1981;Falk et al, 1985;Rudski & Rebandel, 1985;Pigatto et al, 1986;Woodward, 1991;Lisi et al, 1997). There has been a report of a patient who experienced an anaphylactic reaction after a steak dinner.…”

Section: Antimicrobial Drugsmentioning

confidence: 99%

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Woodward¹

2005

Vet Pharm & Therapeutics

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Although seemingly rare, adverse reactions to veterinary products do occur. These may arise from inadvertent exposure during use or as a result of occupational accidents. They are often mild in nature and include adverse effects such as minor skin reactions. However, more serious reactions may occur, and they are not restricted to the effects of the veterinary medicines themselves. For example, high-pressure injection injuries may occur as a result of accidents occurring during animal vaccination operations. This paper reviews some of these events, mentions where appropriate the regulatory actions taken, and describes some of the measures used to minimise such effects in the future, and serves to bring the issues discussed here to the attention of pharmacologists, pharmacoepidemiologists and others who train those who use veterinary medicinal products.

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“…Na identificação de antibióticos concentramos nossa atenção nos resíduos de penicilina (Tabela 5), em virtude dos acidentes alérgicos observados nos consumidores de leite 12,32,34 e dos problemas que acarretam à indústria de laticí-nios 3,4,6,11,14,15,17,18 .…”

Section: As Marcas a B E D Apresentaram Resí-duos (090%)unclassified

Inibidores bacterianos no leite tipo ''B" comercializado no município de São Paulo, SP (Brasil)

Martins

1985

Rev. Saúde Pública

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No leite tipo "B", comercializado no município de São Paulo, SP (Brasil), foram pesquisadas a presença de inibidores bacterianos (penicilina, água oxigenada, formol e cloro). As amostras de leite utilizadas foram provenientes das quatro marcas de maior consumo pela população, coletadas no período de 14 de julho de 1982 a 20 de março de 1983. Foi constatada alta prevalência de inibidores bacterianos (4,70%). A incidência de resíduos de penicilina e de inibidores não identificados foi de 0,7% e de 3,40%, respectivamente. Houve uma baixa proporção de amostras com água oxigenada e formol e ausência de cloro.

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Chronic Penicillin Urticaria from Dairy Products, Proved by Penicillinase Cures

Cited by 47 publications

References 7 publications

Penicillin in milk—its importance in urticaria

Penicillin in milk—its importance in urticaria

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Inibidores bacterianos no leite tipo ''B" comercializado no município de São Paulo, SP (Brasil)

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