Chronic Penicillin Urticaria from Dairy Products, Proved by Penicillinase Cures

Penicillin in milk—its importance in urticaria

“…Other processes such as the manufacture of cream, butter or dried milk powder might increase the concentration of penicillin or its products. The use of penicillinase by injection or addition to food has been advocated [4] but the enzyme is itself allergenic and is no longer used.…”

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

“…During the use of veterinary medicines, and especially medicated feeds, there is potential for worker exposure to antimicrobial drugs and allergic reactions have occurred as a result of such exposures (Mauranges, 1972; Neldner, 1972; Becker, 1976). Dermatitis has also occurred following occupational exposure to penicillin residues in the milk of treated cattle (Erskine, 1958; Zimmerman, 1959; Borrie & Barrett, 1961). The nitrofuran drug furazolidone is known to cause contact dermatitis (Hull & de Beer, 1977; Ancona, 1985; Altamirano & Bondani, 1989) and this has been reported after exposure to veterinary medicinal products containing the drug (de Groot & Conemans, 1990).…”

“…Contact dermatitis and urticaria, either as a result of systemic sensitisation or repeated dermal exposure can also occur, for example, following the ingestion of contaminated foods or due to occupational exposure to penicillin present as residues in milk or to penicillin itself (Erskine, 1958;Vickers et al, 1958;Kautz, 1959;Zimmerman, 1959;Borrie & Barrett, 1961;Vickers, 1964;Stewart, 1967a,b;Reisman & Arbesman, 1968;Minkin & Lynch, 1969;Wicher et al, 1969;Mauranges, 1972;Olson & Sanders, 1975;Cany, 1977;Girard, 1978;Lindemayr et al, 1981;Falk et al, 1985;Rudski & Rebandel, 1985;Pigatto et al, 1986;Woodward, 1991;Lisi et al, 1997). There has been a report of a patient who experienced an anaphylactic reaction after a steak dinner.…”

Inibidores bacterianos no leite tipo ''B" comercializado no município de São Paulo, SP (Brasil)

“…Na identificação de antibióticos concentramos nossa atenção nos resíduos de penicilina (Tabela 5), em virtude dos acidentes alérgicos observados nos consumidores de leite 12,32,34 e dos problemas que acarretam à indústria de laticí-nios 3,4,6,11,14,15,17,18 .…”