Chronic obstructive pulmonary disease in heart failure. Prevalence, therapeutic and prognostic implications

Mascarenhas, Joana; Lourenço, Patrícia; Lopes, Ricardo; Azevedo, Ana; Bettencourt, Paulo

doi:10.1016/j.ahj.2007.10.040

Cited by 95 publications

(93 citation statements)

References 40 publications

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“…The reverse is also likely to be true. 39% of heart failure outpatients were found to have COPD, which was associated with a shorter time to hospital admission or death [37]. The prevalence of COPD in heart failure appears to be similar in those with normal and abnormal ejection fractions, suggesting that much of the heart failure seen in COPD overall will not be characterized by a reduced ejection fraction.…”

Section: Heart Failure Secondary To Ischemic Heart Disease And/or Hypermentioning

confidence: 90%

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Patel

Hurst

2011

Expert Review of Respiratory Medicine

134

107

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Section: Heart Failure Secondary To Ischemic Heart Disease And/or Hypermentioning

confidence: 90%

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Patel

Hurst

2011

Expert Review of Respiratory Medicine

134

107

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“…Several clinical studies and literature reviews [2][3][4][5][6][7][8][9][10][11] emphasise the importance of and need for studies of the prevalence of coexistent CHF and COPD, as well as the prognostic value of each condition in the presence of the other. Although several papers have been published on this topic, to our knowledge none has systematically explored the presence of airway obstruction with spirometry in stable patients with CHF, or ventricular function with echocardiography and neurohormone levels in stable patients with COPD, and followed the patients for a significant period of time.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that both diseases represent a major challenge for healthcare providers and share some common aetiological and epidemiological factors, there is a lack of relevant studies addressing the often ignored combination of CHF and COPD and still fewer addressing the simple clinical questions of interest to physicians [2][3][4][5][6][7][8][9][10][11]. Unfortunately, most studies of the coexistence of COPD and CHF have established diagnosis criteria in a retrospective way and, in most cases, the diagnoses were not based on spirometry and echocardiography [2,3,6,7,9,10].…”

mentioning

confidence: 99%

Unrecognised ventricular dysfunction in COPD

Macchia¹,

Moncalvo²,

Kleinert³

et al. 2011

European Respiratory Journal

131

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While both chronic congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) impose a substantial disease burden and share aetiological and epidemiological associations, they have largely been studied separately. The aim of our study was to assess the prevalence and the prognostic implications of the coexistence of left ventricular dysfunction in COPD patients and airway obstruction in CHF patients.We used a prospective cohort study including stable o60-yr-old patients with echocardiographically confirmed CHF (n5201) and stable o60-yr-old patients with clinically and spirometryconfirmed COPD (n5218). All CHF patients underwent routine spirometry, and all COPD patients underwent routine echocardiographic assessment and B-type natriuretic peptide (BNP) measurement. Patients were followed for 2 yrs.The prevalence of airway obstruction among CHF patients was 37.3% and the prevalence of ventricular dysfunction among COPD patients was 17%. The presence of ventricular dysfunction in patients with COPD tended to increase the risk of mortality during follow-up (hazard ratio 2.34, 95% CI 0.99-5.54; p50.053). The presence of airway obstruction in patients with CHF did not influence survival.CHF and COPD frequently coexist, and ventricular dysfunction worsens survival in patients with COPD. Considering the high prevalence and the prognostic implications of ventricular dysfunction, routine assessment with either BNP or echocardiogram should be considered in COPD patients.

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“…This is regularly reported in the literature and should be specifically addressed, given the major role of b-blockers in improving the prognosis of heart failure. There were no data on COPD severity in this cohort, but the results of a less recent study on a smaller number of patients with heart failure are particularly interesting because they took into account the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades of patients with concomitant COPD [37]. Indeed, whereas COPD status was not associated with a significant increase in mortality over the 14.2¡8.8 months of follow-up, the survival curves for the various stages of COPD severity revealed that survival among patients with GOLD grades 3 or 4 was significantly lower.…”

Section: Shared Pathophysiological Mechanismsmentioning

confidence: 99%

Comorbidities of COPD

Cavaillès¹,

Brinchault-Rabin²,

Dixmier³

et al. 2013

European Respiratory Review

377

239

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By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality. Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco smoking is a common risk factor for many comorbidities, including coronary heart disease, heart failure and lung cancer. Comorbidities such as pulmonary artery disease and malnutrition are directly caused by COPD, whereas others, such as systemic venous thromboembolism, anxiety, depression, osteoporosis, obesity, metabolic syndrome, diabetes, sleep disturbance and anaemia, have no evident physiopathological relationship with COPD. The common ground between most of these extrapulmonary manifestations is chronic systemic inflammation.All of these diseases potentiate the morbidity of COPD, leading to increased hospitalisations and healthcare costs. They can frequently cause death, independently of respiratory failure. Comorbidities make the management of COPD difficult and need to be evaluated and treated adequately. @ERSpublications Extrapulmonary comorbidities are common in COPD and influence prognosis; we propose an exhaustive comorbidities review

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Chronic obstructive pulmonary disease in heart failure. Prevalence, therapeutic and prognostic implications

Cited by 95 publications

References 40 publications

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Unrecognised ventricular dysfunction in COPD

Comorbidities of COPD

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