Chronic obstructive pulmonary disease in patients with lung cancer: prevalence, impact and management challenges

Spyratos, Dionisios; Papadaki, Eleni; Lampaki, Sofia; Kontakiotis, Theodoros

doi:10.2147/lctt.s117178

Cited by 16 publications

(11 citation statements)

References 71 publications

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“…Smoking causes transformation of normal cells into cancer cells with large mutation burden and poor histologic type [ 18 – 20 ]. Also, it induces chronic airway and systemic inflammation, leading to impaired lung function and sarcopenia that are closely related to poor prognosis in lung cancer [ 21 , 22 ]. In this study, even after adjusting for cancer stage which had the most significant effect on survival, the OS of the high-risk group was significantly decreased in both early (I, II) and advanced stages (III, IV).…”

Section: Discussionmentioning

confidence: 99%

Impact of smoking amount on clinicopathological features and survival in non-small cell lung cancer

Ban¹,

Yeo²,

Han³

et al. 2020

BMC Cancer

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Background: Screening for early detection of lung cancer has been performed in high-risk individuals with smoking history. However, researches on the distribution, clinical characteristics, and prognosis of these high-risk individuals in an actual cohort are lacking. Thus, the objective of this study was to retrospectively review characteristics and prognosis of patients with smoking history in an actual lung cancer cohort. Methods: The present study used the lung cancer cohort of the Catholic Medical Centers at the Catholic University of Korea from 2014 to 2017. Patients with non-small cell lung cancer were enrolled. They were categorized into high and low-risk groups based on their smoking history using the national lung screening trial guideline. Distribution, clinical characteristics, and survival data of each group were estimated. Results: Of 439 patients, 223 (50.8%) patients were in the high-risk group. Patients in the high-risk group had unfavorable clinical characteristics and tumor biologic features. Overall survival of the high-risk group was significantly shorter than that of the low-risk group with both early (I, II) and advanced stages (III, IV). In multivariate analysis, heavy smoking remained one of the most important poor clinical prognostic factors in patients with lung cancer. It showed a dose-dependent relationship with patients' survival. Conclusions: High-risk individuals had poor clinical outcomes. Patients' prognosis seemed to be deteriorated as smoking amount increased. Therefore, active screening and clinical attention are needed for high-risk individuals.

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Section: Discussionmentioning

confidence: 99%

Impact of smoking amount on clinicopathological features and survival in non-small cell lung cancer

Ban¹,

Yeo²,

Han³

et al. 2020

BMC Cancer

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“…In the submerged cultures under normoxia, although the OCT4 mRNA level showed a nearly 3-fold increase in DHBE cells compared to the level in NHBE cells ( Figure 10A ), the OCT4 protein level was comparable between NHBE and DHBE cells ( Figure 9K ). Given that multiple lines of evidence have shown the positive correlation between COPD and lung cancers ( Raviv et al, 2011 ; Durham and Adcock, 2015 ; Spyratos et al, 2017 ; Young and Hopkins, 2018 ; Parris et al, 2019 ), which are generally characterized by increased OCT4 protein expression in the malignant airway epithelial tissues ( Chen et al, 2008 ; Karoubi et al, 2009 ; Chiou et al, 2010 ; Zhang X. et al, 2010 ; Bora-Singhal et al, 2015 ), it is plausible that increased OCT4 mRNA expression in the undifferentiated DHBE cells, which preceded increased OCT4 protein expression, may be a predisposing factor for lung cancer development in the COPD population. On the other hand, surprisingly, the OCT4 mRNA levels were comparable among the differentiated NHBE and DHBE tissues cultured under normoxia, intermittent H/R or consecutive hypoxia ( Figure 10I ), which may be primarily attributable to the dramatically reduced expression levels of OCT4 in the ALI-cultured and differentiated HBE tissues, which showed at least 50% decreases compared to the levels in the submerged and undifferentiated HBE cells ( Figure 10J ).…”

Section: Discussionmentioning

confidence: 99%

Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells

Yang

Lin

Wang

et al. 2020

Front. Cell Dev. Biol.

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Previous studies have shown that the experimental models of hypoxia-reoxygenation (H/R) mimics the physiological conditions of ischemia-reperfusion and induce oxidative stress and injury in various types of organs, tissues, and cells, both in vivo and in vitro, including human lung adenocarcinoma epithelial cells. Nonetheless, it had not been reported whether H/R affected proliferation, apoptosis, and expression of stem/progenitor cell markers in the bronchial epithelial cells. In this study, we investigated differential effects of consecutive hypoxia and intermittent 24/24-h cycles of H/R on human bronchial epithelial (HBE) cells derived from the same-race and agematched healthy subjects (i.e., NHBE) and subjects with chronic obstructive pulmonary disease (COPD) (i.e., DHBE). To analyze gene/protein expression during differentiation, both the NHBE and DHBE cells at the 2nd passage were cultured at the air-liquid interface (ALI) in the differentiation medium under normoxia for 3 days, followed by either culturing under hypoxia (1% O 2) for consecutively 9 days and then returning to normoxia for another 9 days, or culturing under 24/24-h cycles of H/R (i.e., 24 h of 1% O 2 followed by 24 h of 21% O 2 , repetitively) for 18 days in total, so that all differentiating HBE cells were exposed to hypoxia for a total of 9 days. In both the normal and diseased HBE cells, intermittent H/R significantly increased HIF1A, BMP4, NOTCH1, MKI67, OCT4, and MUC5AC expression, while consecutive hypoxia significantly decreased NKX2-1, NOTCH3, HEY1, CC10, and FOXJ1 expression.

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“…Eighty to 90% lung cancer cases are caused by cigarette smoking [31] which has many adverse health consequences. The most common comorbidities in patients with lung cancerall of which can progressively and negatively impact healthare chronic obstructive pulmonary disease (COPD, in 50-70% of patients [32,33]), diabetes (16%), and HF (13%) [5]. In addition, the effects of curative-intent therapy of lung cancer have unique effects on cardiopulmonary health since part of the therapy requires local destruction and/or removal of lung tissue which may impede function and EC in some patients.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Dyspnea in Lung Cancer Survivors Following Curative-Intent Therapy

Ries

2018

Preprint

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word count 250)Purpose Dyspnea is highly-prevalent in lung cancer survivors following curative-intent therapy. We aimed to identify clinical determinants of dyspnea and characterize its relationship with functional exercise capacity (EC). MethodsIn an analysis of data from a cross-sectional study of lung cancer survivors who completed curative-intent therapy for stage I-IIIA disease ≥1 month previously, we tested a thorough list of comorbidities, lung function, and lung cancer characteristics. We assessed dyspnea using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Lung Cancer Module 13 (LC13) and functional EC the six-minute walk. We verified results with the University of California San Diego Shortness of Breath Questionnaire (SOBQ). ResultsIn 75 participants at a median of 12 months since completing treatment, the mean (SD) LC13-Dyspnea score was 35.3 (26.2); 60% had abnormally-high dyspnea. In multivariable linear regression analyses, significant clinical determinants of dyspnea were [β (95% confidence interval)]: psychiatric illness [-20.8 (-32.4, -9.09) for No/Yes], heart failure with reduced ejection fraction [-15.5 (-28.0, -2.97) for No/Yes], and forced expiratory volume in 1 second [-0.28 (-0.49, -0.06) for each % predicted]. Dyspnea was an independent predictor of functional EC [-1.54 (-2.43, -0.64) for each point]. These results were similar with the SOBQ.Conclusion

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Chronic obstructive pulmonary disease in patients with lung cancer: prevalence, impact and management challenges

Cited by 16 publications

References 71 publications

Impact of smoking amount on clinicopathological features and survival in non-small cell lung cancer

Impact of smoking amount on clinicopathological features and survival in non-small cell lung cancer

Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells

Characterization of Dyspnea in Lung Cancer Survivors Following Curative-Intent Therapy

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