Chronic obstructive pulmonary disease concurrent with metabolic syndrome: Pathophysiological and clinical features

Budnevsky, A. V.; Ovsyannikov, Evgeniy; Labzhania, N B

doi:10.17116/terarkh2017891123-127

Cited by 14 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The analysis of the literature suggests that hypothyroidism in manifest or subclinical forms is quite common among the comorbidities that can affect the prognosis of HF [33][34][35]. The differences in these groups of patients in terms of overall mortality can be explained by the heterogeneity of the groups by sex, age, degree of TSH level change and duration of follow-up.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hypothyroidism on the Development and course of Heart Failure

Tokmachev¹,

Budnevsky²,

Shkatova³

et al. 2021

PJMHS

View full text Add to dashboard Cite

Thyroid gland dysfunction is a risk factor for development of cardiovascular diseases. From all types of thyroid gland dysfunction hypothyroidism is the most common. Increasing of thyroid-stimulating hormone level can influence the clinical course of chronic heart failure (CHF) because of its extrathyroid effects - namely - influence on lipide metabolism, endothelial function of vessels and blood pressure. Also CHF itself can make negative impact on a thyroid gland functioning, therefore pathophysiological "vicious circle" is formed. Manifest hypothyroidism is associated with an increased risk of general and cardiovascular mortality and frequency of hospitalizations of CHF patients. Association between subclinical hypothyroidism and heart failure is less studied. Figuring out the mechanisms of influence of thyroid gland hypofunction on systolic and diastolic function of myocardium may be important for effective treatment of heart failure and improvement of clinical outcomes. MeSH words: heart failure; hypothyroidism; thyroid-stimulating hormone (TSH); review.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effect of Hypothyroidism on the Development and course of Heart Failure

Tokmachev¹,

Budnevsky²,

Shkatova³

et al. 2021

PJMHS

View full text Add to dashboard Cite

show abstract

“…Osteoarthritis (OA) is one of the less studied comorbidities of asthma. It has been shown that prevalence of osteoarthritis in patients with asthma is significantly higher compared with chronic obstructive pulmonary disease and subjects with no respiratory diseases [9,10]. Mahmood Z. et al found that asthmatic patients who had higher rate of emergency hospitalizations also had a higher risk of developing OA [11].…”

Section: Introductionmentioning

confidence: 99%

Physical Activity and Life Quality in Patients with Asthma and Osteoarthritis

Ivanchuk¹,

Трибунцева²,

Budnevsky³

et al. 2021

PJMHS

View full text Add to dashboard Cite

Background. Physical activity is associated with better asthma control and life quality in asthma. Osteoarthritis is one of the less studied comorbidities in asthmatic patients. Methods. The study included 38 patients diagnosed with asthma, 65 patients with asthma and osteoarthritis, and 40 volunteers who did not suffer from asthma and osteoarthritis. During the study, 3 groups were formed: Group 1 consisted of patients with asthma; Group 2 included patients with both asthma and osteoarthritis, Control group consisted of volunteers. Spirometry, Asthma Quality of Life Questionnaire (AQLQ), Asthma Control Test (АСТ) were used in asthmatic patients. International Physical Activity Questionnaire (IPAQ) in its short from was filled by all the participants. Results. Both Group 1 and Group 2 did not engage in vigorous physical activity. Median of MET-min/week total (1825) was significantly less in Group 2 compared with Control and Group 1 (p=0.0000 and p=0.0169, respectively). MET-min/week total had positive correlations with ACT (r=0.50, p<0.05), AQLQ(S) total (r=0.58, p<0.05), AQLQ(S) activity domain (r=0.28, p<0.05), AQLQ(S) emotions domain (r=0.24, p<0.05), AQLQ (S) symptoms domain (r=0.34, p<0.05), FVC (r=0,28, p<0.05), FEV1 (r=0,37, p<0.05), Index Tiffno (r=0,18, p<0.05). Minutes/week sitting time had a negative correlation with ACT values (r=-0.33, p<0.05), AQLQ(S) total values (r=-0.39, p<0.05). Conclusion. Patients with asthma and osteoarthritis spend significantly less time on moderate activity, walking compared with asthmatics not suffering from osteoarthritis; they avoid vigorous activity. Higher physical activity is associated with better life quality, asthma control and lung function, thus paying attention to osteoarthritis in asthmatic patients is crucial. Key words: life quality, physical activity, asthma, osteoarthritis

show abstract

“…The prevalence of comorbidities is quite high: more than 50% of patients with COPD have 1–2 comorbidities, 15.8% have 3–4, and 6.8% have more than 5 [6]. In general, in patients with COPD, attention is paid to the following pathologies: cardiovascular diseases, osteoporosis, skeletal muscle dysfunction, weight loss [7,8,9]. However, it is important to take into account such conditions as anxiety and depression, which, according to several studies, significantly affect the course of the disease.…”

Section: Introductionmentioning

confidence: 99%

Influence of Anxiety/Depression on the Subjective Evaluation of Cough in Patients with Chronic Obstructive Pulmonary Disease and Obesity

et al. 2019

View full text Add to dashboard Cite

Background and objectives: Obesity and anxiety and/or depression are common comorbidities in patients with chronic obstructive pulmonary disease (COPD). For doctors treating COPD, cough has a certain importance as a symptom. The purpose of this study was to figure out how obesity and anxiety/depression may influence the subjective assessment of cough. Materials and Methods: 110 patients with COPD participated in the study. The patients were divided into two groups, one including obese patients, and the other including patients with normal body weight. All patients filled out the hospital anxiety and depression scale (HADS) questionnaire, evaluated the severity of their cough by using visual analogue scale (VAS) on the 1st and 10th day of treatment, and underwent a 12 h cough monitoring with a special cough monitoring device both on the 1st and the 10th day of treatment. Results: The severity of anxiety according to the HADS in patients with COPD and normal body weight was significantly higher than in patients with COPD and obesity, corresponding to 9.25 ± 1.37 and 8.20 ± 1.18 points, respectively (p = 0.0063). The patients with normal body weight and obesity, but without anxiety and depression, subjectively noted an improvement in their well-being on the 10th day of treatment (p = 0.0022, p = 0.0021, respectively). In subgroups with normal body weight and obesity with anxiety and/or depression, the mean values for VAS on day 10 did not change significantly (p = 0.1917, p = 0.1921, respectively). Also, patients from the subgroup with normal body weight and anxiety/depression had a significantly higher assessment of their cough on day 10 than obese patients with anxiety/depression (p = 0.0411). The VAS values correlated positively with the actual amount of cough (r = 0.42, p = 0.0122 and r = 0.44, p = 0.0054, respectively) in patients without anxiety and/or depression, while in patients with anxiety and/or depression, there was an inverse correlation between VAS values and cough (r = −0.38, p = 0.0034 and r = −0.40, p = 0.0231). Conclusions: It is important to diagnose and treat anxiety and depression in patients with COPD for a better prognosis and higher efficacy of medical treatments. While treating such patients, it is preferable to use a cough monitoring device for objective assessments, since the patients may exaggerate or underestimate their symptoms.

show abstract

Chronic obstructive pulmonary disease concurrent with metabolic syndrome: Pathophysiological and clinical features

Cited by 14 publications

References 33 publications

The Effect of Hypothyroidism on the Development and course of Heart Failure

The Effect of Hypothyroidism on the Development and course of Heart Failure

Physical Activity and Life Quality in Patients with Asthma and Osteoarthritis

Influence of Anxiety/Depression on the Subjective Evaluation of Cough in Patients with Chronic Obstructive Pulmonary Disease and Obesity

Contact Info

Product

Resources

About