1976
DOI: 10.1111/j.1365-2230.1976.tb01399.x
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Chronic muco-cutaneous candidiasis of late onset, thymoma and myopathy. A REPORT OF FOUR CASES

Abstract: Summary A patient with late onset chronic muco‐cutaneous candidiasis, a thymoma and myasthenia gravis is described. Brief reports are added of three other patients with closely similar syndromes. Immunological studies and electron microscopic findings are recorded and discussed. The presence of a thymoma should always be suspected in patients with chronic mucocutaneous candidiasis of late onset.

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Cited by 17 publications
(3 citation statements)
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“…Therefore, it may be difficult to describe an immunologic pattern that includes all patients. The most common deficiency appears to be one of cell-mediated immune responses against candida antigens, as discussed below, although abnormalities in chemotaxis or phagocytic cell function have also been reported (176,222,235,276,282). Other host defense mechanisms, such as humoral immunity and the complement system, have generally been found to be normal in these patients (76,144,145,147,275).…”
Section: Cutaneous Candidiasismentioning
confidence: 98%
“…Therefore, it may be difficult to describe an immunologic pattern that includes all patients. The most common deficiency appears to be one of cell-mediated immune responses against candida antigens, as discussed below, although abnormalities in chemotaxis or phagocytic cell function have also been reported (176,222,235,276,282). Other host defense mechanisms, such as humoral immunity and the complement system, have generally been found to be normal in these patients (76,144,145,147,275).…”
Section: Cutaneous Candidiasismentioning
confidence: 98%
“…defective neutrophil and/or mononuclear chemotaxis(Il,12,16,30). reduced granulocytic chemotactic and phagocytic capacities (4), and subnorrnal candicidal capacity(28), As long as his cutaneous infection flourished, the present patient's neutrophils exhibited poor killing of Staph. aureus, irrespective of whether fresh au tologous or homologous serum was used as opso nins.…”
mentioning
confidence: 82%
“…Occasionally CMC occurs for the first time in adulthood, usually after the fourth decade of life. Associated conditions include thymoma and myasthenia gravis (6).…”
Section: What Syndrome Is This?mentioning
confidence: 99%