Chronic Liver Disease and Metabolic Comorbidities in Healthy Young Males Followed for 65 Years: The Manitoba Follow-up Study

Uhanova, Julia; O’Brien, Meaghan; Minuk, Gerald; Tate, Robert B.

doi:10.1016/j.cgh.2020.10.028

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 39 Similarly, a very recent study performed in a long-term community prospective cohort with 65 years follow-up identified arterial hypertension as the strongest predictor of chronic liver disease, followed by insulin resistance/T2DM and obesity. 40 However, in a large cohort of 603 patients with biopsy-proven NAFLD, there was no independent relationship between liver lesions observed in NAFLD and cardiovascular events, the latter being driven by metabolic risk factors. 41 Additional data are needed to demonstrate that patients with cardiovascular disease are at an increased risk of advanced liver disease and that screening for advanced fibrosis is relevant in this population.…”

Section: In Which Populations Should Case Finding Be Focusedmentioning

confidence: 98%

Case-finding strategies in non-alcoholic fatty liver disease

Boursier

Tsochatzis

2021

JHEP Reports

View full text Add to dashboard Cite

Summary Among the large population of patients with non-alcoholic fatty liver disease (NAFLD), identifying those with advanced disease remains challenging. Many patients are diagnosed late, following the development of liver-related complications, leading to poor clinical outcomes. Accumulating evidence suggests that using non-invasive tests for liver fibrosis in patients with metabolic risk factors improves the detection of patients in need of specialised management and is cost-effective. Because of the vast number of patients requiring evaluation, the active participation of general practitioners and physicians who manage patients with metabolic disorders, such as diabetologists, is crucial; this calls for the increased awareness of NAFLD beyond liver clinics. Non-invasive case-finding strategies will need to be further validated and generalised for upcoming drug therapies to have the required impact on the worldwide burden of NAFLD.

show abstract

Section: In Which Populations Should Case Finding Be Focusedmentioning

confidence: 98%