Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators

Stokić, Edita; Romani, Andrea; Ilinčić, Branislava; Kupusinac, Aleksandar; Stosić, Z; Isenović, Esma R.

doi:10.2174/1570161115666170821154841

Cited by 6 publications

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“…Prospective data on the effect of vitamin D supplementation in these patients will be collected and analyzed. Consistent evidences from large, randomized, placebo-control trials with adequate statistic power and eventually exploring the association of vitamin D and other nutritional elements ( 46 ) are warranted to confirm these findings.…”

Section: Discussionmentioning

confidence: 85%

“…Recently, the concomitant deficiency of magnesium and vitamin D in obesity has been associated with an increased risk of cardiometabolic disease ( 45 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

“…For instance, vitamin D deficiency might represent one of the environmental factors in the pathogenesis and progression of T2DM, obesity and MetS. A detailed metabolic phenotyping could support more qualified intervention programs and detect patients at higher risk for metabolic disorders ( 20 , 23 , 30 , 31 , 46 , 47 , 48 , 49 ).…”

Section: Discussionmentioning

confidence: 99%

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Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?

Piantanida

Gallo

Veronesi

et al. 2017

Endocrine Connections

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ObjectiveThe aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity.Design and methodsOne hundred ninety-six consecutive patients (152 women; mean age 51 ± 13 years) with visceral obesity (mean body weight 103 ± 20 kg, mean waist circumference (WC) 119 ± 13 cm) were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D (25(OH)D)), fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed. Vitamin D status was defined according to the European Society of Endocrinology guidelines, MetS to the 2009 harmonized definition.ResultsAn inverse association emerged among 25(OH)D, body mass index (BMI) (P = 0.001) and WC (all P = 0.003). Serum 25(OH)D levels were inversely related to FBG and systolic blood pressure (SBP) (respectively, P = 0.01 and 0.02). Median serum 25(OH)D levels were 13.3 ng/mL (CI 95% 12; 15) in MetS and 16 ng/mL (CI 95% 14; 18) (P = 0.01) in non-MetS patients. Among patients with MetS, lower 25(OH)D concentrations were related to higher risk of hypertension (HT) (odds ratio (OR) 1.7, CI 95%, 0.7;4) and hyperglycemia (IFG)/type 2 diabetes (OR 5.5, CI 95% 2; 14).ConclusionVitamin D status and MetS are inversely correlated in visceral obesity, particularly with regard to glucose homeostasis and BP. More extensive studies are required to investigate the potential for causality.

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Section: Discussionmentioning

confidence: 85%

“…Recently, the concomitant deficiency of magnesium and vitamin D in obesity has been associated with an increased risk of cardiometabolic disease ( 45 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?

Piantanida

Gallo

Veronesi

et al. 2017

Endocrine Connections

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“…Moreover, chronic latent Mg 2+ deficiency and/or Vitamin D deficiency predispose non-diabetic obese subjects to an increased risk of cardiometabolic diseases. Meanwhile, maintaining a normal Mg 2+ status improves the beneficial effect of Vitamin D on cardiometabolic risk indicators [ 57 ]. Interestingly, an interventional study performed on healthy women showed a significant increase in serum concentration of Mg 2+ in obese but not in non-obese subjects after vitamin D intramuscular injection, probably caused by increased Mg 2+ renal retention induced by vitamin D and emphasized by baseline Mg 2+ deficiency of the obese subjects [ 58 ].…”

Section: Mg 2+ and Obesitymentioning

confidence: 99%

Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

et al. 2021

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Magnesium (Mg2+) deficiency is probably the most underestimated electrolyte imbalance in Western countries. It is frequent in obese patients, subjects with type-2 diabetes and metabolic syndrome, both in adulthood and in childhood. This narrative review aims to offer insights into the pathophysiological mechanisms linking Mg2+ deficiency with obesity and the risk of developing metabolic syndrome and type 2 diabetes. Literature highlights critical issues about the treatment of Mg2+ deficiency, such as the lack of a clear definition of Mg2+ nutritional status, the use of different Mg2+ salts and dosage and the different duration of the Mg2+ supplementation. Despite the lack of agreement, an appropriate dietary pattern, including the right intake of Mg2+, improves metabolic syndrome by reducing blood pressure, hyperglycemia, and hypertriglyceridemia. This occurs through the modulation of gene expression and proteomic profile as well as through a positive influence on the composition of the intestinal microbiota and the metabolism of vitamins B1 and D.

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“…Absorption and excretion is under hormonal control. However, there is no one single hormon responsible for Mg homeostasis but parathyroid hormone, estrogen, calcitonin, glucagon and 1,25-dihydroxyvitamin D surely influence together the balance of intake, utilization and excretion [9,10].…”

Section: Magnesium the Indispensible Cationmentioning

confidence: 99%

Dietary Magnesium Supplements – Is there any Problem?

Télessy¹

2018

jnhfs

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Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators

Cited by 6 publications

References 0 publications

Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?

Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?

Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

Dietary Magnesium Supplements – Is there any Problem?

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