Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies

Wang, Kexin; Qing-yuan, Liu; Tang, Mingyu; Qi, Guangdong; Qiu, Chong; Huang, Yan Yan Shery; Yu, Weiran; Wang, Wei; Sun, Hualin; Ni, Xuejun; Shen, Yuntian; Fang, Xingxing

doi:10.1016/j.bcp.2022.115407

Cited by 21 publications

(23 citation statements)

References 150 publications

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“…Numerous studies have focused on the mechanisms underlying CKD, with scar formationmediated progressive renal injury recognized as a common pathogenic pathway responsible for its development. [6][7][8] The pathological hallmark of CKD involves the accumulation of a substantial amount of extracellular matrix in the glomerulus and renal interstitium, which disrupts normal renal tissue architecture and interacts with renal tubular epithelial cells, myofibroblasts, and immune cells, further exacerbating the progression to renal fibrosis and nephron loss. [9,10] Dysbiosis of the gut microbiota has been implicated in the development of various diseases.…”

Section: Bibliometric Analysis Of the Relationship Between Gut Microb...mentioning

confidence: 99%

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Tao,

Huo,

Chen

2024

Integr Med Nephrol Androl

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Background: The gut microbiota is closely associated with chronic kidney disease (CKD) development and prognosis. However, a comprehensive understanding of publication trends and research focuses within this domain remains limited. This study aimed to elucidate the relationship between the gut microbiota and CKD through a bibliometric analysis. Methods: Literature published between 2001 and 2022 on gut microbiota and CKD was obtained from the Web of Science Core Collection database. Bibliometric analysis tools such as VOSviewer and CiteSpace were used to analyze research trends in this area. Results: We extracted 758 articles for further analysis. China ranked first with 240 published documents, followed by the USA with 211. However, the USA ranked first regarding citation frequency with 11,380 citations, while China ranked second. The University of California Irvine and Kidney International emerged as the leading institution and journal, respectively, with the former leading in document production and citations. Although Kidney International featured fewer documents than other journals, it exhibited the highest citation count. The keywords representing the research interests mainly included: (1) gut microbiota influences the development of CKD, (2) application of probiotics in the treatment of CKD, and (3) potential mechanism of gut microbiota in CKD. Conclusion: Our analysis indicates significant advancements in understanding the association between gut microbiota and CKD. It also provides a comprehensive overview of publication trends, research hotspots, and frontiers, which may provide guidelines for future research.

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Section: Bibliometric Analysis Of the Relationship Between Gut Microb...mentioning

confidence: 99%

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Tao,

Huo,

Chen

2024

Integr Med Nephrol Androl

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“…By activating the UPS and blocking the IGF-1/phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) signaling pathways, metabolic acidosis speeds up muscle atrophy [ 101 ]. While IGF-1/PI3K/AKT functions as the most significant anabolic pathway in muscle tissue, the UPS is the primary regulatory mechanism for protein breakdown in skeletal muscle [ 101 ]. Additionally, activation of AKT also inhibits protein degradation in skeletal muscle by stimulating the phosphorylation and inactivation of FOXO transcription factors.…”

Section: Recommended Approach and Potential Treatments For Ckd-associ...mentioning

confidence: 99%

“…Additionally, activation of AKT also inhibits protein degradation in skeletal muscle by stimulating the phosphorylation and inactivation of FOXO transcription factors. As a result, metabolic acidosis simultaneously stimulates protein breakdown and inhibits protein synthesis, as well as causing oxidative stress and inflammation in muscle tissue [ 101 ].…”

Section: Recommended Approach and Potential Treatments For Ckd-associ...mentioning

confidence: 99%

“…Since increased protein catabolism and CKD-induced muscle atrophy may be caused by an aberrant GH/IGF-1 physiological axis, GH plays a key role in muscle gain [ 94 , 95 ]. Figure 2 illustrates the results of GH administration in CKD-associated cachexia and muscle wasting [ 99 , 101 , 102 ].…”

Section: Recommended Approach and Potential Treatments For Ckd-associ...mentioning

confidence: 99%

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Redox Signaling in Chronic Kidney Disease-Associated Cachexia

et al. 2023

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Redox signaling alterations contribute to chronic kidney disease (CKD)-associated cachexia. This review aims to summarize studies about redox pathophysiology in CKD-associated cachexia and muscle wasting and to discuss potential therapeutic approaches based on antioxidant and anti-inflammatory molecules to restore redox homeostasis. Enzymatic and non-enzymatic systems of antioxidant molecules have been studied in experimental models of kidney diseases and patients with CKD. Oxidative stress is increased by several factors present in CKD, including uremic toxins, inflammation, and metabolic and hormone alterations, leading to muscle wasting. Rehabilitative nutritional and physical exercises have shown beneficial effects for CKD-associated cachexia. Anti-inflammatory molecules have also been tested in experimental models of CKD. The importance of oxidative stress has been shown by experimental studies in which antioxidant therapies ameliorated CKD and its associated complications in the 5/6 nephrectomy model. Treatment of CKD-associated cachexia is a challenge and further studies are necessary to investigate potential therapies involving antioxidant therapy.

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“…For example, patients with CKD and ESKD often present with peripheral neuropathy 10 , which can cause motor dysfunction. The common complications of CKD include anemia, cardiovascular disease, decreased red blood cell survival, iron deficiency, malnutrition, muscle weakness, and osteoporosis due to disturbances in calcium, vitamin D, and phosphate metabolism 4, 11 . Both anemia and malnutrition can directly contribute to muscle dysfunction 11, 12 .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Accidental Falls in the Patients with Chronic Kidney Diseases: A 14-Year Retrospective Study and Review

Liao,

Zhang,

Peng

et al. 2023

Preprint

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BackgroundAccidental falls pose a high-risk that should not be overlooked in patients with chronic kidney disease (CKD), as they can result in significant injury or even fatality. This study aimed to investigate the characteristics of CKD patients with fall injuries during hospitalization, discuss potential mechanisms, and to provide an overview of existing prevention methods.MethodsFalls of all patients in our Nephrology ward from 2009 to 2022 were recorded and counted. 48 patients were enrolled. Patient characteristics, injury distribution, cause of fall injury, relevant blood biochemical indicators, and recovery conditions were counted.ResultsThere were 22,053 hospitalized patients during the study period, with a fall rate of approximately 0.218%. Patients are prone to involuntary falls due to muscle weakness and confusion during nighttime and early morning activities. Injuries are mainly to the head and there is a risk of serious injury and fracture. CKD is associated with anemia, hypertension, water-electrolytes imbalance and secondary hyperparathyroidism. Blood tests showed that patients commonly had anemia, malnutrition, low immunity, as well as abnormal muscle and neuromodulatory ion levels, such as low calcium, low potassium and high phosphorus. Moreover, Patients usually have low blood pressure control ability.ConclusionLong-term CKD may lead to subjective dysfunction and motor dysfunction by inducing anemia, malnutrition, water-electrolytes imbalance, and blood pressure control ability, thus making patients prone to falls. This study has important implications for hospital ward safety management and fall prevention in CKD patients.

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Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies

Cited by 21 publications

References 150 publications

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Redox Signaling in Chronic Kidney Disease-Associated Cachexia

Characteristics of Accidental Falls in the Patients with Chronic Kidney Diseases: A 14-Year Retrospective Study and Review

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