Chronic interstitial lung disease in children: Response to high-dose intravenous methylprednisolone pulses

Efficacy and tolerance of intravenous methylprednisolone pulses in children with severe bronchopulmonary dysplasia requiring respiratory support

“…Desmarquet et al reported 3 patients aged 4 to 17 month s treated by IVMP for chronic interstitial lung disease. 29 No infections were reported. Yed et al studied IVMP in a cohort of 14 infants with West Syndrome with a median age of 7 months.…”

“…Few studies have reported IVMP tolerance in neonates and young infants when used for other indications. Desmarquet et al reported 3 patients aged 4 to 17 month s treated by IVMP for chronic interstitial lung disease 29 . No infections were reported.…”

The lost chILD: a case report of delayed diagnosis of Surfactant Protein C Deficiency in a 15-year-old African male

“…Anti-in ammatory and immunomodulatory therapies, such as high-dose corticosteroids, hydroxychloroquine and/or azithromycin, are commonly used to treat SPDS 3,4,9,10,12,15 . Glucocorticoids, which are expected to reduce in ammation and have been shown to increase the expression of ABCA3, may be considered as rst line treatment [16][17][18] An individualized therapeutic regimen is essential for optimizing outcomes and minimizing side effects in SPDS treatment. This regimen should include an initial high-dose therapy (oral prednisolone at 1-2 mg/Kg/day or pulse methylprednisolone at 10-30 mg/Kg/day for three consecutive days, repeated at monthly intervals), a careful tapering phase, and maintenance therapy, along with regular monitoring.…”

Caso clínico-radiológico

“…Su incidencia es desconocida y difícil de estimar, por lo pequeño de los casos en las diferentes series clínicas. En un estudio en Reino Unido e Irlanda en niños de 0 a 16 años de edad la incidencia fue de 0,36 por 100.000 (5)(6)(7)(8)(9) . Dentro de los mecanismos patogénicos involucrados juega un rol importante la inflamación, reclutándose células proinflamatorias e inmunorreguladoras en el intersticio, alvéolos y tejidos perialveolares, en algunos casos pueden observarse grados variables de fibrosi (6) .…”