Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway

Katare, Rajesh; Kakinuma, Yoshihiko; Arikawa, Mikihiko; Yamasaki, Fumiyasu; Sato, Takayuki

doi:10.1016/j.yjmcc.2008.10.027

Cited by 89 publications

(78 citation statements)

References 31 publications

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“…Previous studies have described multiple salutary effects of intermittent fasting on life-span prolongation in C. elegans 54 and rodents; 22,55 reduction in infarct size with improved mortality and attenuation of postinfarction remodeling in the heart; 23,24 improved glucose regulation and attenuation of hypoxic insult in neurons 25 in experimental models; and remarkable effects on weight loss and improved glucose-regulation in obese women. 21 Our study extends these observations by defining the need for an optimal frequency and duration of the fasting regimen to derive the cardioprotective effects; and suggests the hypothesis that …”

Section: Discussionmentioning

confidence: 99%

“…23,24 To investigate whether reduced frequency of fasting or shorter duration of intermittent fasting regimens confer similar cardioprotection; and to determine whether the observed benefits extend to ischemia-reperfusion injury, we subjected adult male wild-type mice to 24 h of fasting on an every other day schedule (qOD; quaque otra die) for 2 and 6 wk; or on an every 4 th d schedule (q4D; quaque qutra die) for 6 wk; and provided ad libitum access to standard chow to nonfasted controls; followed by ischemia-reperfusion modeling with reversible LAD ligation performed on a fed day to induce ischemia (30 min) followed by reperfusion (for 23.5 h; see Fig. S1A for experimental scheme).…”

Section: Intermittent Fasting Confers Cardioprotection To Ischemiarepmentioning

confidence: 99%

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Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

et al. 2015

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(2015) Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemiareperfusion injury, Autophagy, 11:9, 1537-1560, DOI: 10.1080/15548627.2015 Keywords: autophagy, fasting, ischemia-reperfusion, lysosome, myocardial infarctionAbbreviations: CMA, chaperone-mediated autophagy; CQ, chloroquine; GFP, green fluorescent protein; LAD, left anterior descending; LAMP2, lysosomal-associated membrane protein 2; MOI, multiplicity of infection; NRCMs, neonatal rat ventricular cardiac myocytes; q4D, quaque qutra die/every fourth day; qOD, quaque otra die/every other day; TFEB, transcription factor EB; MAP1LC3B (also abbreviated as LC3), microtubule-associated protein 1 light chain 3, isoform B; TTC, triphenyl tetrazolium chloride; LV, left ventricle; AAR, area at risk; WT, wild type.Autophagy, a lysosomal degradative pathway, is potently stimulated in the myocardium by fasting and is essential for maintaining cardiac function during prolonged starvation. We tested the hypothesis that intermittent fasting protects against myocardial ischemia-reperfusion injury via transcriptional stimulation of the autophagy-lysosome machinery. Adult C57BL/6 mice subjected to 24-h periods of fasting, every other day, for 6 wk were protected from invivo ischemia-reperfusion injury on a fed day, with marked reduction in infarct size in both sexes as compared with nonfasted controls. This protection was lost in mice heterozygous null for Lamp2 (coding for lysosomal-associated membrane protein 2), which demonstrate impaired autophagy in response to fasting with accumulation of autophagosomes and SQSTM1, an autophagy substrate, in the heart. In lamp2 null mice, intermittent fasting provoked progressive left ventricular dilation, systolic dysfunction and hypertrophy; worsening cardiomyocyte autophagosome accumulation and lack of protection to ischemia-reperfusion injury, suggesting that intact autophagy-lysosome machinery is essential for myocardial homeostasis during intermittent fasting and consequent ischemic cardioprotection. Fasting and refeeding cycles resulted in transcriptional induction followed by downregulation of autophagy-lysosome genes in the myocardium. This was coupled with fasting-induced nuclear translocation of TFEB (transcription factor EB), a master regulator of autophagy-lysosome machinery; followed by rapid decline in nuclear TFEB levels with refeeding. Endogenous TFEB was essential for attenuation of hypoxia-reoxygenation-induced cell death by repetitive starvation, in neonatal rat cardiomyocytes, in-vitro. Taken together, these data suggest that TFEBmediated transcriptional priming of the autophagy-lysosome machinery mediates the beneficial effects of fastinginduced autophagy in myocardial ischemia-reperfusion injury.

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Section: Discussionmentioning

confidence: 99%

Section: Intermittent Fasting Confers Cardioprotection To Ischemiarepmentioning

confidence: 99%

Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

et al. 2015

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“…For example, CR prevented learning and memory deficits despite extensive CA1 neuronal degeneration induced by forebrain ischemia (Roberge et al, 2008). Rats subjected to chronic intermittent fasting after myocardial ischemia induction were more likely to survive, showed reductions in infarct size, and had increased expression of antiapoptotic proteins (Katare et al, 2009). Furthermore, CR upregulated angiogenic factors and increased capillary density after myocardial ischemia (Katare et al, 2009) and was also shown to accelerate revascularization in mice after hindlimb ischemia (Kondo et al, 2009).…”

Section: Caloric Restriction Activates Sirtuins and Mediates Lifespanmentioning

confidence: 99%

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

Morris

Lin

Thompson

et al. 2011

J Cereb Blood Flow Metab

118

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Caloric restriction (CR), resveratrol, and ischemic preconditioning (IPC) have been shown to promote protection against ischemic injury in the heart and brain, as well as in other tissues. The activity of sirtuins, which are enzymes that modulate diverse biologic processes, seems to be vital in the ability of these therapeutic modalities to prevent against cellular dysfunction and death. The protective mechanisms of the yeast Sir2 and the mammalian homolog sirtuin 1 have been extensively studied, but the involvement of other sirtuins in ischemic protection is not yet clear. We examine the roles of mammalian sirtuins in modulating protective pathways against oxidative stress, energy depletion, excitotoxicity, inflammation, DNA damage, and apoptosis. Although many of these sirtuins have not been directly implicated in ischemic protection, they may have unique roles in enhancing function and preventing against stress-mediated cellular damage and death. This review will include in-depth analyses of the roles of CR, resveratrol, and IPC in activating sirtuins and in mediating protection against ischemic damage in the heart and brain.

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“…Thus NTS and A 1 AR contribute significantly towards induction of hypothermia and modulation of cardiovascular responses. Dietary restriction is a dietary regimen defined by a decrease in food intake unassociated with malnutrition which lowers core body temperature, improves longevity, protects heart and attenuates progression of neurodegenerative diseases in animal models (Contestabile, 2009;Katare et al, 2009). These effects have been suggested to be through a reduction in metabolic demand (Ungvari et al, 2008) associated with a decrease in body temperature (Tb) (Conti et al, 2006).…”

Section: Significance Of Adenosine On Dietary Restriction Induced Hypmentioning

confidence: 99%

Natural Protection Against Cardiac Arrhythmias During Hibernation: Significance of Adenosine

Jinka¹

2012

Cardiac Arrhythmias - New Considerations

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Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway

Cited by 89 publications

References 31 publications

Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

Natural Protection Against Cardiac Arrhythmias During Hibernation: Significance of Adenosine

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