Chronic intermittent elemental diet improves growth failure in children with Crohn's disease

Belli, Dominique Charles; Seidman, Ernest G.; Bouthillier, L. P.; Weber, Andrée; Roy, Claudie; Pletincx, Michel; Beaulieu, Marie-Claude; Morin, Claude

doi:10.1016/0016-5085(88)90230-2

Cited by 254 publications

(129 citation statements)

References 32 publications

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“…Its role in children with chronic disorders has been studied extensively. It was associated with an arrest in the deterioration of lung function in children with cystic ®brosis (Levy et al, 1985;Shepherd et al, 1986); reduced spasticity in children with cerebral palsy (Patrick et al, 1986); a reduction in the need for surgery in infants with gastro-oesophageal re¯ux (Ferry et al, 1983); better growth in children with Crohn's disease, compared with those given corticosteroids (Belli et al, 1988;Papadopoulou et al, 1995b); and achievement of weight gain in children with congenital heart disease (Bougle et al, 1986) and in children with chronic renal failure (Rees et al, 1989). Furthermore, enteral feeds have a bene®cial effect on gut mucosal barrier function in experimental animals (Inoue et al, 1989), and in humans (Moore et al, 1989).…”

Section: The Role Of Enteral Nutrition (En)mentioning

confidence: 99%

Nutritional considerations in children undergoing bone marrow transplantation

Papadopoulou

1998

Eur J Clin Nutr

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Bone marrow transplantation is often associated with multiple organ failure which is usually reversible. Oral mucositis and dysphagia, vomiting, diarrhoea, protein losing enteropathy, transient exocrine pancreatic impairment, hypoalbuminaemia, biochemical trace element and mineral de®ciencies are all common following transplantation and have profound nutritional consequences. Malnutrition affects negatively the clinical outcome. Nutritional support is provided to malnourished patients and those who suffer deterioration in nutritional status despite the provision of dietetic counselling. Only a few randomised studies comparing enteral with parenteral nutrition after transplant exist. Both enteral tube feeding (in the absence of mucositis) and parenteral nutrition are effective in maintaining nutritional status. However, enteral nutrition is associated with a better nutritional response and fewer complications than parenteral. With existing enteral and parenteral nutrition regimens close monitoring of trace element and mineral status is required.

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Section: The Role Of Enteral Nutrition (En)mentioning

confidence: 99%

Nutritional considerations in children undergoing bone marrow transplantation

Papadopoulou

1998

Eur J Clin Nutr

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“…However, first Papadopoulou et al [93] and recently, Lambert et al [94] have shown a significant (though small) benefit in height z-score at 1 and 2 years respectively, following a single course of EEN at diagnosis in comparison with initial corticosteroid treatment. Several strategies for long-term partial enteral nutrition exist including cyclical EEN (EEN for 1 month in every 4 months) and nocturnal EEN (EEN 4-7 nights per week with unrestricted daytime diet) which showed, in a retrospective cohort, significant benefit on growth compared to no nutritional treatment [95], or other conventional therapies [96]. It may be concluded that when growth is concerned, EEN is superior to corticosteroid therapy in the short-term and that nutritional supplementation during maintenance phase may contribute to linear growth.…”

Section: Exclusive Enteral Nutrition (Een)mentioning

confidence: 99%

Impact of Therapeutic Strategies on Growth in Pediatric Inflammatory Bowel Disease

Shamir¹

2014

J Clin Cell Immunol

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Growth retardation is a common complication of pediatric inflammatory bowel disease (IBD), which may have long term effects on final adult height and carries significant social and psychological implications. Etiology may be multifactorial including undernutrition, metabolic dysregulation, inflammatory impact on hormonal growth axis and the effect of drugs such as glucocorticoids. Control of disease activity and minimizing the need for corticosteroid therapy are necessary measures in order to facilitate normal growth. However, in many cases these strategies are not sufficient. Currently, there is inconsistent evidence regarding the efficacy of available therapeutic agents to induce long-term effect on growth. The new era of biologic therapies which carries a greater potential to achieve mucosal healing, holds promise for better growth even in children with severe growth impairment. It becomes apparent that prompt recognition of growth impairment combined with aggressive tailored therapeutic approach may offer the best chance for catch-up growth. This review will discuss the definition, prevalence and mechanism of growth retardation in children with IBD and highlight the specific benefits of current therapeutic strategies.

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“…The advantages of EN include its stimulatory effects on gastrointestinal structure and function as well as its reduced cost compared to parenteral feeding. Oral nutritional supplements (with 500-600 kcal/day) and/or tube feeding improve the nutritional status in adults and especially in children with CD (19)(20)(21). In fact, 50% of growth-retarded CD patients cannot regain their body weight through medical therapy alone and must use enteral tube feeding (22).…”

Section: Nutritional Support Therapymentioning

confidence: 99%

Nutritional treatment in inflammatory bowel disease: An update

Guagnozzi

González-Castillo

Olveira

et al. 2012

Rev. esp. enferm. dig.

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Background and aims: enteral (EN) and parenteral (TPN) nutrition exert variable therapeutic effects on the induction and maintenance of remission in inflammatory bowel disease (IBD).This review aims to provide an updated discussion on the complex relationship between diet and IBD.Methods: medline, Cochrane and Scopus database searches were conducted. Sources cited in the articles obtained were also searched to identify other potential sources of information.Results: nutritional status is significantly compromised in IBD patients, especially those with Crohn's disease (CD). Apart from restoring malnourishment, dietary components contribute to modulate intestinal immune responses. Nutritional treatment is divided into support therapy and primary therapy to induce and maintain remission through TPN and EN. EN is considered a first-line therapy in children with active CD whereas it is usually used in adult CD patients when corticosteroid therapy is not possible. TPN has limited effects on IBD.En formula composition, in terms of carbohydrates, nitrogen source and bioactive molecules supplementation, differentially influence on IBD treatment outcomes. Other dietary components, such as poorly absorbed short-chain carbohydrate, polyols, and exogenous microparticles, also participate in the etiopathogenesis of IBD. Finally, new approaches to understanding the complex relationship between IBD and diet are provided by nutrigenenomic.Conclusion: further long-term, well-powered studies are required to accurately assess the usefulness of nutrition in treating IBD. In future research, the potential role of nutrient-gene interaction in drug trials and specific dietary formula compositions should be investigated in order to incorporate new knowledge about the etiopathology of IBD into nutritional intervention.

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Chronic intermittent elemental diet improves growth failure in children with Crohn's disease

Cited by 254 publications

References 32 publications

Nutritional considerations in children undergoing bone marrow transplantation

Nutritional considerations in children undergoing bone marrow transplantation

Impact of Therapeutic Strategies on Growth in Pediatric Inflammatory Bowel Disease

Nutritional treatment in inflammatory bowel disease: An update

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