Chronic inflammatory demyelinating polyneuropathy: quality of life, sociodemographic profile and physical complaints

Santos, Plácida Leopoldina Ventura Amorim da Costa; Ribeiro, Graziela Aparecida Nogueira de Almeida; Silva, Daniele Miguel Daoud; Marques, Wilson; Barreira, Amilton Antunes

doi:10.1590/0004-282x20130232

Cited by 19 publications

(32 citation statements)

References 19 publications

(22 reference statements)

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“…Pain is the most common cause of functional impairment in the clinical practice, commonly seen in axonal neuropathies. Pain was a complaint in 48.8% of patients in Santos et al 5 series. A very interesting presentation of CIDP with only painful symptoms, most in the distal legs and responsive to immunoglobulin has been reported 6 .…”

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confidence: 92%

“…Among the various associated signs and symptoms involved in the functional evaluation of patients with demyelinating diseases, two have called attention: fatigue and impaired cognition. One-third (34.1%) of Santos et al 5 patients complained of weakness, fatigue or tiredness at the time of evaluation, showing that they are frequent. Thus, fatigue should be considered when assessing psychological profile and QoL in CIDP and variants.…”

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confidence: 96%

“…Recent studies have highlighted that CI should be looked for, regardless of the disease duration or clinical course 9 . Santos et al 5 report memory deficit in 34.1% of their CIDP patients, bringing the question about the association of CI and CIDP. Studies with proper instruments focusing the presence of CI in demyelinating neuropathies, regarding the relationship with duration and clinical course, could be interesting.…”

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confidence: 98%

“…Pain and difficulty in walking are very frequent complaints resulting in a negative socioeconomic impact to the patient. Functional capacity has been evaluated in CIDP patients, but only in Santos et al 5 report we found information about work activity, and leisure reduction during the disease.…”

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confidence: 99%

“…Studies with proper instruments focusing the presence of CI in demyelinating neuropathies, regarding the relationship with duration and clinical course, could be interesting. It is very important to exclude associated health problem as diabetes, arterial hypertension, hypothyroidism and others, referred in 65.9% of cases in Santos et al series 5 . Considering the socioeconomic profile and QoL is important in the evaluation of effective new therapeutic perspectives.…”

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confidence: 99%

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Impairment of quality of life and cognition in demyelinating neuropathies: targets to be considered from diagnosis to treatment?

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confidence: 92%

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Impairment of quality of life and cognition in demyelinating neuropathies: targets to be considered from diagnosis to treatment?

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Neuropsychiatric manifestations in inflammatory neuropathies: A systematic review

2016

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We conducted a systematic literature review on psychological and behavioral comorbidities in patients with inflammatory neuropathies. In Guillain–Barré syndrome (GBS), psychotic symptoms are reported during early stages in 30% of patients. Typical associations include mechanical ventilation, autonomic dysfunction, inability to communicate, and severe weakness. Anxiety and depression are frequent comorbidities. Anxiety may increase post‐hospital admissions and be a predictor of mechanical ventilation. Posttraumatic stress disorder may affect up to 20% of ventilated patients. Sleep disturbances are common in early‐stage GBS, affecting up to 50% of patients. In chronic inflammatory demyelinating polyradiculoneuropathy, memory and quality of sleep may be impaired. An independent link between depression and pretreatment upper limb disability and ascites was reported in POEMS (polyneuropathy, organomegaly, endocrinopathy, M‐protein, skin) syndrome, with an association with early death. Hematological treatment of POEMS appears effective on depression. Published literature on psychological/behavioral manifestations in inflammatory neuropathies remains scarce, and further research is needed. Muscle Nerve 54: 1–8, 2016

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Quality of life predictors in patients with chronic inflammatory demyelinating polyradiculoneuropathy

et al. 2017

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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic disease which can lead to many functional impairments, and like most other chronic disorders it might significantly affect quality of life (QoL). Information about QoL in patients with CIDP from developing countries is still lacking. We, therefore, sought to complete these data mosaic by investigating QoL in patients with CIDP from Serbia and surrounding countries. Our study comprised 106 patients diagnosed with CIDP. QoL was investigated using the Serbian version of the SF-36 questionnaire. The Medical Research Council 0-5 point scale, INCAT motor and sensory scores, Krupp's Fatigue Severity Scale, and Beck Depression Inventory were also used. Factors that significantly correlated with SF-36 total score in univariate analysis were included in the multiple linear regression analysis. Physical domains of the SF-36 were more affected than mental, and the overall score was 56.6 ± 25.4. Significant predictors of worse SF-36 score in our patients with CIDP were severe fatigue (β = - 0.331, p < 0.01), higher INCAT motor score (β = - 0.301, p < 0.01), depression (β = - 0.281, p < 0.01), being unemployed/retired (β = - 0.188, p < 0.05), and shorter duration of CIDP (β = + 0.133, p < 0.01). QoL was reduced in CIDP patients, especially in physical domains. Patients with presence of fatigue and depression, with more severe motor disability, unemployed/retired ones, and those with shorter duration of the disease need special attention of clinicians since they could be at higher risk to have worse QoL.

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Chronic inflammatory demyelinating polyneuropathy: quality of life, sociodemographic profile and physical complaints

Abstract: CIDP has important social and economic impacts, owing to functional impairments that can lead to professional and personal limitations.

Cited by 19 publications

References 19 publications

Impairment of quality of life and cognition in demyelinating neuropathies: targets to be considered from diagnosis to treatment?

Impairment of quality of life and cognition in demyelinating neuropathies: targets to be considered from diagnosis to treatment?

Neuropsychiatric manifestations in inflammatory neuropathies: A systematic review

Quality of life predictors in patients with chronic inflammatory demyelinating polyradiculoneuropathy

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