Chronic Hepatitis C in Alcoholic Patients: Studies with Various Hcv Assay Procedures

Ishii, Kunihide; Furudera, Shigeki; Tanaka, Shinpei; Kumashiro, Ryukichi; Sata, Michio; Abe, Hirohiko; Tanikawa, Kyuichi

doi:10.1093/alcalc/28.supplement_1a.71

Cited by 7 publications

(3 citation statements)

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“…Many studies suggested that HCV infection may act as a negative cofactor in chronic liver disease caused by alcohol 57 ; however, they investigated selected samples of alcoholics [58][59][60][61][62] or of patients affected by ''alcoholic liver disease.'' 48,50,52,[63][64][65][66] For the first time, we have considered alcohol intake as a quantitative independent variable, avoiding the a priori diagnosis of ''alcoholic'' or ''nonalcoholic'' chronic liver disease established using arbitrary thresholds.…”

Section: Discussionmentioning

confidence: 99%

Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis

Corrao

Aricò²

1998

Hepatology

301

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Although alcohol intake and hepatitis C virus (HCV) infection are the major determinants of liver cirrhosis (LC) in Western countries, the joint effect of these two factors on LC risk has not yet been adequately studied. We used data from two hospital-based case-control studies performed in Italy. Cases were 285 cirrhotic patients admitted for the first time to district hospitals for liver decompensation. Controls were 417 patients admitted during the same period, and in the same hospitals as the cases, for acute diseases unrelated to alcohol. Alcohol consumption was expressed as lifetime daily alcohol intake (LDAI). Serum HCV antibodies (anti-HCV) were detected using a secondgeneration test and recombinant immunoblotting assay. We found a dose-effect relationship between LDAI and the risk of LC in both anti-HCV-negative and -positive subjects. Considering the extreme LDAI categories (LDAI ‫؍‬ 0 g, lifetime teetotalers, and LDAI ‫؍‬ 175 g), the LC odds ratios increased from 1.0 (reference category) to 15.0 (95% CI, 7.1-31.7) and from 9.2 (95% CI, 2.0-43.2) to 147.2 (95% CI, 42.1-514.3) in anti-HCV-negative and -positive patients respectively. The interaction between LDAI and HCV showed an additive structure for LDAI F50 g/day and a multiplicative structure for consumption G125 g/day. Alcohol intake and HCV infection are independent risk factors for symptomatic liver cirrhosis, each being sufficient to induce the disease. In subjects with high alcohol intake, the coexistence of HCV infection multiplies the alcohol-associated risk of cirrhosis. In subjects with low alcohol intake, other factors could be involved. (HEPATOLOGY 1998;27:914-919.)Alcohol intake represents the main determinant of liver cirrhosis in Italy 1,2 and other Western countries. 3 Evidence in this respect has been given by ecological, 3-5 prevalence, 6-9 case-control, 10-15 and cohort 16,17 studies. However, several observations suggest that other factors should interact with alcohol consumption in causing liver damage. [18][19][20] In alcoholics, liver histology is normal in 5% to 25% of biopsies and 18% of autopsy findings, 21 and cirrhosis develops at a low yearly incidence rate of around 2%. 16 Thus, only 10% to 25% of alcoholics will suffer from cirrhosis during their life. 22 Among these interacting factors, the role of chronic infection with hepatitis B virus is still debated. [23][24][25][26] Similarly, despite the initial suggestion that chronic infection with hepatitis C virus (HCV) may multiplicatively interact with alcohol intake in determining cirrhosis, 27 recent evidence suggests that these two factors act independently. 28 The aim of the present study was to assess, using a case-control design, the risk of developing liver cirrhosis associated with alcohol intake, HCV infection, and the combined action of these factors. PATIENTS AND METHODS Selection of Cases and Controls.We used the data from two hospitalbased case-control studies performed with the same design in two different periods and in two different Italian areas.The desi...

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Section: Discussionmentioning

confidence: 99%

Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis

Corrao

Aricò²

1998

Hepatology

301

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“…Cromie et al [34] reported a decrease in hepatitis C viral load and improvement in disease activity after 4 months of abstinence. However, Ishii et al [20] reported histological progression even after abstinence.…”

Section: Prevalence Of Hepatitis C In Alcoholicsmentioning

confidence: 99%

“…The prevalence rate of HCV antibodies in alcoholics varies between countries. For example, the rate is approximately 10% in the US [14] , 14% in northern Europe and France, [23][24][25] and 45-80% in Japan ( table 1 ) [20,26] . In the US, about 48% of the adult population drinks regularly [27] .…”

Section: Prevalence Of Hepatitis C In Alcoholicsmentioning

confidence: 99%

Alcohol and Hepatitis C

Jamal

Saadi²,

Morgan³

2005

Dig Dis

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Background/Aims: Alcohol use and hepatitis C are prominent risk factors for liver injury and this review offers the current understanding of each factor’s effects on liver disease. Methods: A Medline database search was preformed for English articles with a focus on alcohol, hepatitis C and liver disease. Article citations were also considered for further applicable articles, and the strongest studies were included in our review. Results: Up to 60% of patients with hepatitis C have a past history of alcohol use. In patients with hepatitis C, chronic alcohol consumption of more than 5 drinks/day increases the rate of liver fibrosis, risk for cirrhosis, hepatocellular carcinoma, and, possibly, death from liver disease. Numerous studies have further found that even moderate amounts of alcohol can be detrimental to hepatitis C patients. The prevalence of hepatitis C is higher in alcoholics with advanced liver disease than in alcoholics without liver disease. Also, recent alcohol use decreases the response rate to interferon treatment. Conclusions: Hepatitis C and alcohol use are often co-occurring risk factors for liver disease, and though their interaction is not clear, it is known that heavy drinking significantly promotes liver disease progression.

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Is alcohol a risk factor for liver cirrhosis in HBsAg and anti-HCV negative subjects?

Corrao

Aricò

Zambon

et al. 1997

Journal of Hepatology

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Chronic Hepatitis C in Alcoholic Patients: Studies with Various Hcv Assay Procedures

Cited by 7 publications

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Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis

Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis

Alcohol and Hepatitis C

Is alcohol a risk factor for liver cirrhosis in HBsAg and anti-HCV negative subjects?

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